Sb-742457

ChemicalBook > CAS DataBase List > Sb-742457

Product Name: Sb-742457
CAS No.: 607742-69-8
Chemical Name: Sb-742457
Synonyms: CS-579;RVT-101;CS-2723;Sb-742457;Sb 742457;Gsk 742457;SB-742457(RVT-101);Sb-742457 USP/EP/BP;SB 742457/GSK 742457;SB742457:Intepirdine
CBNumber: CB92495263
Molecular Formula: C19H19N3O2S
Formula Weight: 353.44
MOL File: 607742-69-8.mol

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Sb-742457 Property

Boiling point:: 608.3±45.0 °C(Predicted)
Density: 1.292
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥17.65 mg/mL in DMSO; ≥2.13 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 8?+-.0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22200
Product name: SB-742457
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 22200
Product name: SB-742457
Purity: ≥98%
Packaging: 5mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 22200
Product name: SB-742457
Purity: ≥98%
Packaging: 10mg
Price: $319
Updated: 2024/03/01

Cayman Chemical

Product number: 22200
Product name: SB-742457
Purity: ≥98%
Packaging: 25mg
Price: $704
Updated: 2024/03/01

ApexBio Technology

Product number: B2256
Product name: SB742457
Packaging: 5mg
Price: $105
Updated: 2021/12/16

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Sb-742457 Chemical Properties,Usage,Production

Description

SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT₆ (K_i = 1.4 nM). SB-742457 (1 μM) also binds to 5-HT_1B, 5-HT_2A, 5-HT_2B, and 5-HT_2C receptors with high affinity. SB-742457 reduces 5-HT₆ activation of G_s-mediated cAMP production in a concentration-dependent manner with an EC₅₀ value of 21 nM in NG108-15 neuroblastoma cells. In vivo, SB-742457 (1.5 mg/kg, p.o.) reverses deficits in novel object recognition induced by scopolamine in rats. It also reverses age-induced impairments in spatial memory acquisition and retention in rats in the Morris water maze. SB-742457 (3.0 mg/kg, i.p.) reduces the number of licking bouts by 24% compared with control in rats trained to lick a glucose solution, indicating a role in satiety and obesity management.

Uses

SB 742457 is a selective 5-HT6 receptor antagonist which is known to be involved in improving cognitive function.

target

5-HT6

References

[1] aaron t. t. chuang, andrew foley, perdita l. pugh, david sunter, xin tong, ciaran regan, lee a. dawson, andrew d. medhurst, neil upton.5-ht6 receptor antagonist sb-742457 as a novel cognitive enhancing agent for alzheimer’s disease. alzheimer's & dementia: the journal of the alzheimer's association volume 2, issue 3, supplement, pages s631–s632, july 2006

Sb-742457 Preparation Products And Raw materials

Raw materials

Preparation Products

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Sb-742457 Suppliers

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View Lastest Price from Sb-742457 manufacturers

Career Henan Chemical Co

Product: Sb-742457 607742-69-8
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

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Gsk 742457

Sb 742457

Sb-742457

3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline

SB 742457/GSK 742457

Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-

SB742457:Intepirdine

Intepirdine(SB742457)

3-(BENZENESULFONYL)-8-(PIPERAZIN-1-YL)QUINOLINE

SB 742457;RVT 101;SB742457;RVT101

CS-579

SB-742457(RVT-101)

RVT-101

CS-2723

RVT101. intepirdine.

SB742457; SB 742457; SB-742457; RVT-101; RVT 101; RVT101. INTEPIRDINE.

Sb-742457 USP/EP/BP

Intepirdine (SB-742457, RVT-101）

Intepirdine HCl (SB-742457

SB 742457/GSK 742457/SB742457

607742-69-8

Inhibitors

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