ChemicalBook > CAS DataBase List > KU57788(NU7441)

KU57788(NU7441)

Product Name: KU57788(NU7441)
CAS No.: 503468-95-9
Chemical Name: KU57788(NU7441)
Synonyms: CS-181;NU 7441;KU 57788;KU57788(NU7441);NU-7441 (KU-57788);NU 7441 - KU 47788;KU-57788, 10 mM in DMSO;KU57788(NU7441) USP/EP/BP;NU7441;KU57788;NU 7441 (KU 57788);NU7441 (KU-57788);KU 57788; NU-7441
CBNumber: CB92500947
Molecular Formula: C25H19NO3S
Formula Weight: 413.49
MOL File: 503468-95-9.mol

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KU57788(NU7441) Property

Melting point:: 220-221 °C
Boiling point:: 646.9±55.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: Soluble in DMSO (up to 10 mg/ml with warming).
form: solid
pka: 0.51±0.20(Predicted)
color: Off-white to beige
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14881
Product name: NU 7441
Purity: ≥98%
Packaging: 5mg
Price: $43
Updated: 2024/03/01

Cayman Chemical

Product number: 14881
Product name: NU 7441
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2023/06/20

Cayman Chemical

Product number: 14881
Product name: NU 7441
Purity: ≥98%
Packaging: 10mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 14881
Product name: NU 7441
Purity: ≥98%
Packaging: 25mg
Price: $140
Updated: 2024/03/01

Tocris

Product number: 3712
Product name: NU7441
Purity: ≥99%(HPLC)
Packaging: 10
Price: $227
Updated: 2021/12/16

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KU57788(NU7441) Chemical Properties,Usage,Production

Description

DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments. NU 7441 is a selective DNA-PK inhibitor with an IC₅₀ value of 14 nM. It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC₅₀ values of 1.7, 5, >100, and >100 μM, respectively. NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.

Uses

A potent and selective DNA-PK inhibitor with an IC50 of 14 nM.

Uses

A potent novel DNA-dependent protein kinase inhibitor models of human cancer. Antitumor agent.

Definition

ChEBI: 8-(4-dibenzothiophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of dibenzothiophenes.

IC 50

DNA-PK: 14 nM (IC₅₀); mTOR: 1.7 μM (IC₅₀); PI3K: 5.0 μM (IC₅₀); CRISPR/Cas9

storage

Store at +4°C

References

[1] JUSTIN J.J. LEAHY . Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries[J]. Bioorganic & Medicinal Chemistry Letters, 2004, 14 24: Pages 6083-6087. DOI:10.1016/j.bmcl.2004.09.060
[2] IAN R. HARDCASTLE. Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach[J]. Journal of Medicinal Chemistry, 2005, 48 24: 7829-7846. DOI:10.1021/jm050444b
[3] YAN ZHAO. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.[J]. Cancer research, 2006, 66 10: 5354-5362. DOI:10.1158/0008-5472.can-05-4275
[4] WOJCIECH M CISZEWSKI. DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin.[J]. Breast Cancer Research and Treatment, 2014, 143 1: 47-55. DOI:10.1007/s10549-013-2785-6
[5] CHUANJIE YANG. NU7441 Enhances the Radiosensitivity of Liver Cancer Cells.[J]. Cellular Physiology and Biochemistry, 2016, 38 5: 1897-1905. DOI:10.1159/000445551
[6] WEI GENG. DNA‑PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy.[J]. Oncology reports, 2019, 42 2: 561-570. DOI:10.3892/or.2019.7187

KU57788(NU7441) Preparation Products And Raw materials

Raw materials

Preparation Products

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KU57788(NU7441) Suppliers

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View Lastest Price from KU57788(NU7441) manufacturers

Career Henan Chemical Co

Product: KU57788(NU7441) 503468-95-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

503468-95-9, KU57788(NU7441)Related Search:

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KU57788(NU7441)

NU 7441

8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one

8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one

NU7441 (KU-57788);KU 57788; NU-7441

KU 57788

NU-7441 (KU-57788)

4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one NU-7441

NU 7441 (This product is only available in Japan.)

CS-181

NU 7441 - KU 47788

NU7441;KU57788;NU 7441 (KU 57788)

8-(Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one

KU57788(NU7441) USP/EP/BP

KU-57788, 10 mM in DMSO

503468-95-9

Inhibitors

Heterocycles

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Pharmaceuticals

Sulfur & Selenium Compounds