KU57788(NU7441)

ChemicalBook > CAS DataBase List > KU57788(NU7441)

Product Name: KU57788(NU7441)
CAS No.: 503468-95-9
Chemical Name: KU57788(NU7441)
Synonyms: CS-181;NU 7441;KU 57788;KU57788(NU7441);NU-7441 (KU-57788);NU 7441 - KU 47788;KU-57788, 10 mM in DMSO;KU57788(NU7441) USP/EP/BP;NU7441;KU57788;NU 7441 (KU 57788);NU7441 (KU-57788);KU 57788; NU-7441
CBNumber: CB92500947
Molecular Formula: C25H19NO3S
Formula Weight: 413.49
MOL File: 503468-95-9.mol

Less

KU57788(NU7441) Property

Melting point:: 220-221 °C
Boiling point:: 646.9±55.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: Soluble in DMSO (up to 10 mg/ml with warming).
form: solid
pka: 0.51±0.20(Predicted)
color: Off-white to beige
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 14881
Product name: NU 7441
Purity: ≥98%
Packaging: 5mg
Price: $43
Updated: 2024/03/01

Cayman Chemical

Product number: 14881
Product name: NU 7441
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2023/06/20

Cayman Chemical

Product number: 14881
Product name: NU 7441
Purity: ≥98%
Packaging: 10mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 14881
Product name: NU 7441
Purity: ≥98%
Packaging: 25mg
Price: $140
Updated: 2024/03/01

Tocris

Product number: 3712
Product name: NU7441
Purity: ≥99%(HPLC)
Packaging: 10
Price: $227
Updated: 2021/12/16

Less

KU57788(NU7441) Chemical Properties,Usage,Production

Description

DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments. NU 7441 is a selective DNA-PK inhibitor with an IC₅₀ value of 14 nM. It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC₅₀ values of 1.7, 5, >100, and >100 μM, respectively. NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.

Uses

A potent and selective DNA-PK inhibitor with an IC50 of 14 nM.

Uses

A potent novel DNA-dependent protein kinase inhibitor models of human cancer. Antitumor agent.

Definition

ChEBI: 8-(4-dibenzothiophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of dibenzothiophenes.

storage

Store at +4°C

References

1) Leahy?et al.?(2004),?Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries; Bioorg. Med. Chem. Lett.,?14?6083 2) Hardcastle?et al.?(2005),?Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach: J. Med. Chem.,?48?7829 3) Zhao?et al.?(2006),?Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441: Cancer Res.?66?5354 4) Ciszewski?et al.?(2014),?DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin: Breast Cancer Res. Treat.,?143?83 5) Yang?et al.?(2016),?NU7441 Enhances the Radiosensitivity of Liver Cancer Cells: Cell Physiol. Biochem.,?38?1897 6) Geng?et al.?(2019),?DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy: Oncol. Rep.,?42?561

KU57788(NU7441) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

KU57788(NU7441) Suppliers

Canada 1 China 111 Germany 1 India 1 Japan 1 United Kingdom 2 United States 19 Global 136

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4728
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

SYN|thesis med chem P/L

Tel: +86-021-50720296
Fax: +86-021-50720297
Email: service@synkinase.com
Country: China
ProdList: 266
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 1316706386
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 7295
Advantage: 60

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai XingMo Biotechnology Co., Ltd.

Tel: +86 13524779951; 13524779951
Fax: QQ: 2075692521
Email: 2075692521@qq.com
Country: China
ProdList: 310
Advantage: 55

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9958
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4587
Advantage: 55

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1002
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai Wishpharma Co.,Ltd.

Tel: 021-56789108 18694901298
Fax: 021-56789108
Email: 95413064@qq.com
Country: China
ProdList: 267
Advantage: 56

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 17687
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29764
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Resuperpharmtech Co., Ltd.

Tel: 02150565560; 17321237488
Email: kevin@resuperpharmtech.com
Country: China
ProdList: 357
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1927
Advantage: 55

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28805
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3254
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1990
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1991
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 22787
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3600
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Less

View Lastest Price from KU57788(NU7441) manufacturers

Career Henan Chemical Co

Product: KU57788(NU7441) 503468-95-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

503468-95-9, KU57788(NU7441)Related Search:

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Levetiracetam N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) BI 2536 CHLOROPICRIN & ETHYLENE DIBROMIDE Indole Dibenzofuran Bortezomib NU7026 KU-55933 (ATM Kinase Inhibitor) VE-821 Ibrutinib Olaparib

KU57788(NU7441)

NU 7441

8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one

8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one

NU7441 (KU-57788);KU 57788; NU-7441

KU 57788

NU-7441 (KU-57788)

4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one NU-7441

NU 7441 (This product is only available in Japan.)

CS-181

NU 7441 - KU 47788

NU7441;KU57788;NU 7441 (KU 57788)

8-(Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one

KU57788(NU7441) USP/EP/BP

KU-57788, 10 mM in DMSO

503468-95-9

Inhibitors

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds