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KU57788(NU7441)

Product Name
KU57788(NU7441)
CAS No.
503468-95-9
Chemical Name
KU57788(NU7441)
Synonyms
CS-181;NU 7441;KU 57788;KU57788(NU7441);NU-7441 (KU-57788);NU 7441 - KU 47788;KU-57788, 10 mM in DMSO;KU57788(NU7441) USP/EP/BP;NU7441;KU57788;NU 7441 (KU 57788);NU7441 (KU-57788);KU 57788; NU-7441
CBNumber
CB92500947
Molecular Formula
C25H19NO3S
Formula Weight
413.49
MOL File
503468-95-9.mol
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KU57788(NU7441) Property

Melting point:
220-221 °C
Boiling point:
646.9±55.0 °C(Predicted)
Density 
1.376±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
Soluble in DMSO (up to 10 mg/ml with warming).
form 
solid
pka
0.51±0.20(Predicted)
color 
Off-white to beige
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14881
Product name
NU 7441
Purity
≥98%
Packaging
5mg
Price
$43
Updated
2024/03/01
Cayman Chemical
Product number
14881
Product name
NU 7441
Purity
≥98%
Packaging
1mg
Price
$26
Updated
2023/06/20
Cayman Chemical
Product number
14881
Product name
NU 7441
Purity
≥98%
Packaging
10mg
Price
$77
Updated
2024/03/01
Cayman Chemical
Product number
14881
Product name
NU 7441
Purity
≥98%
Packaging
25mg
Price
$140
Updated
2024/03/01
Tocris
Product number
3712
Product name
NU7441
Purity
≥99%(HPLC)
Packaging
10
Price
$227
Updated
2021/12/16
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KU57788(NU7441) Chemical Properties,Usage,Production

Description

DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments. NU 7441 is a selective DNA-PK inhibitor with an IC50 value of 14 nM. It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC50 values of 1.7, 5, >100, and >100 μM, respectively. NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.

Uses

A potent and selective DNA-PK inhibitor with an IC50 of 14 nM.

Uses

A potent novel DNA-dependent protein kinase inhibitor models of human cancer. Antitumor agent.

Definition

ChEBI: 8-(4-dibenzothiophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of dibenzothiophenes.

storage

Store at +4°C

References

1) Leahy?et al.?(2004),?Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries; Bioorg. Med. Chem. Lett.,?14?6083 2) Hardcastle?et al.?(2005),?Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach: J. Med. Chem.,?48?7829 3) Zhao?et al.?(2006),?Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441: Cancer Res.?66?5354 4) Ciszewski?et al.?(2014),?DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin: Breast Cancer Res. Treat.,?143?83 5) Yang?et al.?(2016),?NU7441 Enhances the Radiosensitivity of Liver Cancer Cells: Cell Physiol. Biochem.,?38?1897 6) Geng?et al.?(2019),?DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy: Oncol. Rep.,?42?561

KU57788(NU7441) Preparation Products And Raw materials

Raw materials

Preparation Products

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KU57788(NU7441) Suppliers

Canada 1 China 111 Germany 1 India 1 Japan 1 United Kingdom 2 United States 19 Global 136
ACTIVATE SCIENTIFIC GmbH
Tel
--
Fax
--
Email
info@activate-scientific.com
Country
Germany
ProdList
2856
Advantage
61
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View Lastest Price from KU57788(NU7441) manufacturers

Career Henan Chemical Co
Product
KU57788(NU7441) 503468-95-9
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

503468-95-9, KU57788(NU7441)Related Search:

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  • KU57788(NU7441)
  • NU 7441
  • 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
  • 8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
  • NU7441 (KU-57788);KU 57788; NU-7441
  • KU 57788
  • NU-7441 (KU-57788)
  • 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-
  • 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one NU-7441
  • NU 7441 (This product is only available in Japan.)
  • CS-181
  • NU 7441 - KU 47788
  • NU7441;KU57788;NU 7441 (KU 57788)
  • 8-(Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one
  • KU57788(NU7441) USP/EP/BP
  • KU-57788, 10 mM in DMSO
  • 503468-95-9
  • Inhibitors
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds