ChemicalBook > CAS DataBase List > 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

Product Name
3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
CAS No.
1164470-53-4
Chemical Name
3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Synonyms
003;Sal 003;CS-1897;(2E)-3-Phenyl-N-(2;SAL-003;SAL 003;SAL003;eIF-2α Inhibitor II, Sal003;Sal-003,Sal 003,Apoptosis,Inhibitor,Sal003,inhibit,Phosphatase;2-trichloro-1-{[(4-chlorophenyl)carbamothioyl]amino}ethyl)acrylamide;(E)-N-(2,2,2-Trichloro-1-(3-(4-chlorophenyl)thioureido)ethyl)cinnamamide;3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
CBNumber
CB92518799
Molecular Formula
C18H15Cl4N3OS
Formula Weight
463.21
MOL File
1164470-53-4.mol
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3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Property

storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
form 
powder
color 
white to off-white
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S4451
Product name
Sal003
Purity
≥98% (HPLC)
Packaging
5mg
Price
$149
Updated
2024/03/01
Sigma-Aldrich
Product number
S4451
Product name
Sal003
Purity
≥98% (HPLC)
Packaging
25mg
Price
$595
Updated
2024/03/01
Cayman Chemical
Product number
23414
Product name
Sal-003
Purity
≥98%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
23414
Product name
Sal-003
Purity
≥98%
Packaging
10mg
Price
$155
Updated
2024/03/01
Tocris
Product number
3657
Product name
Sal003
Purity
≥99%(HPLC)
Packaging
10
Price
$182
Updated
2021/12/16
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3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Chemical Properties,Usage,Production

Uses

Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.

Biological Activity

eukaryotic initiation factor 2 α-subunit (eif2α) plays a critical role in the regulation of protein synthesis. moreover, it also plays an important role in synaptic plasticity and long-term memory consolidation. sal003 is a selective inhibitor of eif2α dephosphorylation.

Biochem/physiol Actions

Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.

in vitro

sal003 specifically prevents dephosphorylation of eif2α by blocking eif2α phosphatases. in sal003-treated cells polysomes dissociated and consistent with this β-actin mrna shifted to lighter fractions, reflecting the inhibition of general translation [1].

in vivo

intra-basolateral amygdala (bla) infusions of sal003 immediately after memory retrieval disrupted the reconsolidation of morphine- or cocaine-induced cpp, leading to a long-lasting suppression of drug-paired stimulus-induced craving. moreover, inhibition of eif2α dephosphorylation in the bla immediately after light/tone stimulus retrieval decreased subsequent cue-induced heroin-seeking behavior in the self-administration procedure. these results demonstrate that eif2α dephosphorylation in the bla mediates the memory reconsolidation of drug-paired stimuli [1].

storage

Store at -20°C

References

[1] jian m, luo yx, xue yx, han y, shi hs, liu jf, yan w, wu p, meng sq, deng jh, shen hw, shi j, lu l. eif2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. j neurosci. 2014;34(30):10010-21.

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Suppliers

Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
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View Lastest Price from 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide manufacturers

Career Henan Chemical Co
Product
1164470-53-4 1164470-53-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kgs
Release date
2019-12-17

1164470-53-4, 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamideRelated Search:


  • SAL-003;SAL 003;SAL003
  • CS-1897
  • (2E)-3-Phenyl-N-(2
  • 2-trichloro-1-{[(4-chlorophenyl)carbamothioyl]amino}ethyl)acrylamide
  • SAL003;(2E)-3-PHENYL-N-(2;2;2-TRICHLORO-1-{[(4-CHLOROPHENYL)CARBAMOTHIOYL]AMINO}ETHYL)ACRYLAMIDE
  • eIF-2α Inhibitor II, Sal003
  • 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
  • Sal 003
  • (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide
  • (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide SAL003
  • 003
  • 2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-, (2E)-
  • (E)-N-(2,2,2-Trichloro-1-(3-(4-chlorophenyl)thioureido)ethyl)cinnamamide
  • Sal-003,Sal 003,Apoptosis,Inhibitor,Sal003,inhibit,Phosphatase
  • 1164470-53-4
  • Inhibitors