ChemicalBook > CAS DataBase List > GNE-490

GNE-490

Product Name
GNE-490
CAS No.
1033739-92-2
Chemical Name
GNE-490
Synonyms
GNE-490;CS-2657;GNE490;GNE 490;GNE-490, 10 mM in DMSO;2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol;2-[2-(2-amino-4-methylpyrimidin-5-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]propan-2-ol;Thieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-4-methyl-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-;2-(2-Amino-4-methyl-5-pyrimidinyl)-alpha,alpha-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol;PI3Kβ,GNE 490,PI3Kδ,Mammalian target of Rapamycin,mTOR,GNE-490,MCF7.1,PI3K,PI3Kα,Phosphoinositide 3-kinase,PI3Kγ,breast cancer,Inhibitor,GNE490,inhibit
CBNumber
CB92621136
Molecular Formula
C18H22N6O2S
Formula Weight
386.47
MOL File
1033739-92-2.mol
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GNE-490 Property

storage temp. 
4°C, protect from light
solubility 
DMSO : ≥ 100 mg/mL (258.75 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
KIN0001422
Product name
GNE-490
Purity
95.00%
Packaging
5MG
Price
$500.76
Updated
2021/12/16
AK Scientific
Product number
SYN1114
Product name
GNE-490
Packaging
10mg
Price
$560
Updated
2021/12/16
Adipogen Life Sciences
Product number
SYN-1114-M010
Product name
GNE-490
Purity
≥95%
Packaging
10mg
Price
$583
Updated
2021/12/16
DC Chemicals
Product number
DC8502
Product name
GNE-490
Purity
>98%
Packaging
100mg
Price
$800
Updated
2021/12/16
DC Chemicals
Product number
DC8502
Product name
GNE-490
Purity
>98%
Packaging
250mg
Price
$1500
Updated
2021/12/16
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GNE-490 Chemical Properties,Usage,Production

Description

GNE-490 is a highly selective pan-PI3K inhibitor, demonstrating selectivity over mTOR.

Uses

GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K inhibitor with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for ?PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model[1].

IC 50

PI3Kα: 3.5 nM (IC50); PI3Kβ: 25 nM (IC50); PI3Kδ: 5.2 nM (IC50); PI3Kγ: 15 nM (IC50); mTOR: 750 nM (IC50)

References

[1] Daniel P Sutherlin, et al. Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem. 2010 Feb 11;53(3):1086-97. DOI:10.1021/jm901284w

GNE-490 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-490 Suppliers

China 27 United Kingdom 1 United States 5 Global 33
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58

1033739-92-2, GNE-490Related Search:

GNE-3511 GNE-9605 GNE-6640 GNF 5837 GNE 477 GNE-955 GNE140 GNE-493 gne-131 GNE 617 GNE 7915

  • GNE-490
  • 2-(2-Amino-4-methyl-5-pyrimidinyl)-alpha,alpha-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol
  • GNE490;GNE 490
  • CS-2657
  • Thieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-4-methyl-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-
  • 2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol
  • PI3Kβ,GNE 490,PI3Kδ,Mammalian target of Rapamycin,mTOR,GNE-490,MCF7.1,PI3K,PI3Kα,Phosphoinositide 3-kinase,PI3Kγ,breast cancer,Inhibitor,GNE490,inhibit
  • 2-[2-(2-amino-4-methylpyrimidin-5-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]propan-2-ol
  • GNE-490, 10 mM in DMSO
  • 1033739-92-2