ChemicalBook > CAS DataBase List > 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-

Product Name: 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-
CAS No.: 913822-46-5
Chemical Name: 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-
Synonyms: 75741;V 1810;SC75741;CS-2697;SC75741 ，S7273;SC75741, 10 mM in DMSO;N-(6-Benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide;4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-;4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- USP/EP/BP
CBNumber: CB92627097
Molecular Formula: C29H23N7O2S2
Formula Weight: 565.67
MOL File: 913822-46-5.mol

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4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Property

Density: 1.483±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form: powder
pka: 9.11±0.10(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2382
Product name: SC75741
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $79
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2382
Product name: SC75741
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $319
Updated: 2025/07/31

Cayman Chemical

Product number: 21818
Product name: SC-75741
Purity: ≥98%
Packaging: 5mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 21818
Product name: SC-75741
Purity: ≥98%
Packaging: 10mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 21818
Product name: SC-75741
Purity: ≥98%
Packaging: 25mg
Price: $306
Updated: 2024/03/01

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4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Chemical Properties,Usage,Production

Description

SC-75741 is an inhibitor of NF-κB (EC₅₀ = 0.1 μM in an NF-κB reporter gene assay). It inhibits replication of human, avian, and swine influenza virus strains in MDCK cells in a concentration-dependent manner. It also reversibly inhibits replication of H5N1 and H7N7 avian influenza virus strains in human A549 cells. In vivo, SC-75741 (15 mg/kg, i.p.) reduces viral mRNA and production of IL-6 and CXCL10/IP-10 in the lungs of H5N1 infected mice. SC-75741 is also protective against H5N1 and H7N7 infection in mice when administered for 7 days prior to or up to 4 days post infection.

Uses

SC75741 is a potent NF-κB inhibitor with EC50.

in vivo

SC75741 (intraperitoneal injection; 15 mg/kg; for 2 days) leads to a reduced propagation of the H5N1 virus mRNA by 90% in the lungs of infected mice^[2].
The plasma-levels of SC74751 (intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; for 3.5 and 6 hours) after i.v. administration decreases mono-exponentially and half-life is roughly 40 min. After i.p. administration, elimination of SC75741 seems to be limited by a slow uptake from the peritoneum and a half-life of 55 min is observed^[1].

Animal Model:	Inbred female C57BL/6 mice at the age of 6-8 weeks^[2]
Dosage:	15?mg/kg
Administration:	Intraperitoneal injection; for 2 days
Result:	Reduced the amount of viral mRNA by 90%.

Animal Model:	Inbred female C57BL/6 mice at the age of 6-8 weeks^[1]
Dosage:	5 mg/kg or 15 mg/kg
Administration:	Intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; 3.5 and 6 hours
Result:	Half-life was roughly 40 min and 55 min for i.v. and i.p. administration, respectively.

target

NF-κB

IC 50

p65: 200 nM (IC₅₀)

References

[1] JOHANN LEBAN. A novel class of potent NF-κB signaling inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2007, 17 21: Pages 5858-5862. DOI: 10.1016/j.bmcl.2007.08.022
[2] CHRISTINA EHRHARDT. The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance[J]. Cellular Microbiology, 2013, 15 7: 1198-1211. DOI: 10.1111/cmi.12108
[3] EMANUEL HAASBACH . The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus[J]. Antiviral research, 2013, 99 3: Pages 336-344. DOI: 10.1016/j.antiviral.2013.06.008

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Suppliers

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913822-46-5, 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-Related Search:

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4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-

SC75741

V 1810

N-(6-Benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide

75741

CS-2697

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- USP/EP/BP

SC75741, 10 mM in DMSO

SC75741 ，S7273

913822-46-5

C29H23N7O2S2

Inhibitors