ChemicalBook > CAS DataBase List > XL413 (BMS-863233)

XL413 (BMS-863233)

Product Name
XL413 (BMS-863233)
CAS No.
1169562-71-3
Chemical Name
XL413 (BMS-863233)
Synonyms
CS-1062;XL413.HCL;BMS-863233 HCl;XL413(BMS-863233);BMS-863233 (XL-413);BMS-863233 HCl salt;XL413 (hydrochloride);XL413 (BMS-863233) HCl;BMS-863233 HCl (XL-413);BMS-863233 Hydrochloride
CBNumber
CB92627547
Molecular Formula
C14H13Cl2N3O2
Formula Weight
326.18
MOL File
1169562-71-3.mol
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XL413 (BMS-863233) Property

storage temp. 
-20°C
solubility 
DMSO: Insoluble;Ethanol: Insoluble
form 
powder
color 
white to beige
Water Solubility 
Water: 46 mg/mL (141.03 mM)
Stability:
Hygroscopic
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Safety

RIDADR 
UN 2811 6.1 / PGIII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1401
Product name
XL413 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$201
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1401
Product name
XL413 hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$663
Updated
2024/03/01
Tocris
Product number
5493
Product name
XL413 hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$952
Updated
2021/12/16
Tocris
Product number
5493
Product name
XL413 hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$227
Updated
2021/12/16
TRC
Product number
X746230
Product name
XL413
Packaging
5mg
Price
$135
Updated
2021/12/16
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XL413 (BMS-863233) Chemical Properties,Usage,Production

Uses

XL413 is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor.

Biological Activity

XL413 hydrochloride is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, its selectivity over CK2, Pim-1 and pMCM2 are 63-, 12- and 35-fold. Phase 1/2.

in vitro

In MDA-MB-231T and Colo-205 cell lines,XL413 hydrochloride inhibits CDC7-specific phosphorylation of MCM2. XL413 also inhibited cell proliferation in Colo-205 cells, decreased cell viability, and stimulated caspase 3/7 activity. Furthermore, XL413 resulted in altered S-phase progression and subsequent apoptosis.

in vivo

In the Colo-205 xenograft model, XL413, at a dose of 3 mg/kg, inhibited 70% of phosphorylated MCM2 and caused significant regression of tumor growth at a dose of 100 mg/kg.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> CK2
(Cell-free assay)
TargetValue
Cdc7
(Cell-free assay)		 3.4 nM
Pim1
(Cell-free assay)		 42 nM
212 nM

storage

Store at -20°C

XL413 (BMS-863233) Preparation Products And Raw materials

Raw materials

Preparation Products

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XL413 (BMS-863233) Suppliers

China 77 United Kingdom 1 United States 15 Global 93
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from XL413 (BMS-863233) manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
XL413 1169562-71-3
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-10-15
Career Henan Chemical Co
Product
XL413 (BMS-863233) 1169562-71-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-13

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  • 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
  • CS-1062
  • XL 413 hydrochloride - BMS 863233 hydrochloride
  • BMS-863233; BMS863233; BMS 863233; XL-413; XL413; XL 413.
  • Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-, (Hydrochloride) (1:)
  • XL413 (hydrochloride)
  • BMS-863233 (XL-413)
  • 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride (1:?)
  • XL413(BMS-863233)
  • BMS-863233 HCl
  • Benzofuro[3,2-d]pyrimidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-, hydrochloride
  • BMS-863233 HCl salt
  • XL413.HCL
  • BMS-863233 HCl (XL-413)
  • (4AR,6S,7R,7AS)-6-[4-[[(1S)-2,3-DIHYDRO-1H-INDEN-1-YL]AMINO]PYRROLO[2,3-D]PYRIMIDIN-7-YL]-2-(4-METHOXYPHENYL)-4,4A,5,6,7,7A-HEXAHYDROCYCLOPENTA[D][1,3]DIOXIN-7-OL
  • BMS-863233 Hydrochloride
  • XL413 (BMS-863233) USP/EP/BP
  • XL413 (BMS-863233) HCl
  • (S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one xhydrochloride
  • XL413 hydrochloride|||BMS-863233 HCl
  • 1169562-71-3
  • C14H12ClN3O2xHCl
  • Inhibitors
  • API