2,4-Dichloro-6-(4-Methoxyphenyl)pyriMidine

Product Name: 2,4-Dichloro-6-(4-Methoxyphenyl)pyriMidine
CAS No.: 163263-91-0
Chemical Name: 2,4-Dichloro-6-(4-Methoxyphenyl)pyriMidine
Synonyms: 2,4-Dichloro-6-(4-methoxyphenyl)primidine;2,4-Dichloro-6-(4-Methoxyphenyl)pyriMidine;Pyrimidine, 2,4-dichloro-6-(4-methoxyphenyl)-
CBNumber: CB92661385
Molecular Formula: C11H8Cl2N2O
Formula Weight: 255.1
MOL File: 163263-91-0.mol

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2,4-Dichloro-6-(4-Methoxyphenyl)pyriMidine Property

Melting point:: 104-105 °C
Boiling point:: 395.7±32.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.26±0.32(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FD141181
Product name: 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine
Packaging: 100mg
Price: $58
Updated: 2021/12/16

AK Scientific

Product number: Z4249
Product name: 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine
Packaging: 100mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD141181
Product name: 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine
Packaging: 250mg
Price: $115
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD141181
Product name: 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD141181
Product name: 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine
Packaging: 1g
Price: $350
Updated: 2021/12/16

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2,4-Dichloro-6-(4-Methoxyphenyl)pyriMidine Chemical Properties,Usage,Production

Synthesis

3764-01-0

5720-07-0

163263-91-0

General procedure: 2,4,6-trichloropyrimidine (5.5 mL, 48 mmol) was dissolved in anhydrous THF (70 mL) under nitrogen protection, and palladium acetate (0.147 g, 0.64 mmol), triphenylphosphine (0.353 g, 1.28 mmol), 4-methoxybenzeneboronic acid (5 g, 31.9 mmol), and 1 M aqueous sodium carbonate (64 mL, 64 mmol). The reaction mixture was stirred at 60 °C for 6 h. The reaction progress was monitored by TLC. Upon completion of the reaction, the mixture was cooled to room temperature and THF was removed by concentration under reduced pressure with a rotary evaporator.Deionized water (100 mL) was added to the residue and extracted with ethyl acetate (100 mL × 3). The organic phases were combined, washed with saturated sodium chloride solution (100 mL), dried over anhydrous sodium sulfate, filtered and the filtrate concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: petroleum ether) to afford 2,4-dichloro-6-(4-methoxyphenyl)pyrimidine as a white solid (5.58 g, 68% yield). Mass spectrum (ESI, positive ion mode) m/z: 255.0 [M + H]+. 1H NMR (400 MHz, CDCl3) δ (ppm): 8.07 (dd, J = 9.4, 2.4 Hz, 2H), 7.60 (s, 1H), 7.08-6.99 (m, 2H), 3.91 (s, 3H).

References

[1] Organic Letters, 2006, vol. 8, # 3, p. 395 - 398
[2] Patent: WO2017/97234, 2017, A1. Location in patent: Paragraph 00234
[3] Patent: WO2018/33082, 2018, A1. Location in patent: Paragraph 00441
[4] Patent: CN108276401, 2018, A. Location in patent: Paragraph 0595; 0597; 0598
[5] Patent: WO2018/127096, 2018, A1. Location in patent: Paragraph 00284

2,4-Dichloro-6-(4-Methoxyphenyl)pyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-6-(4-Methoxyphenyl)pyriMidine Suppliers

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View Lastest Price from 2,4-Dichloro-6-(4-Methoxyphenyl)pyriMidine manufacturers

Career Henan Chemical Co

Product: 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine 163263-91-0
Price: US $2.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20tons
Release date: 2019-12-30

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2,4-Dichloro-6-(4-methoxyphenyl)primidine

2,4-Dichloro-6-(4-Methoxyphenyl)pyriMidine

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163263-91-0