3(S)-HYDROXYMETHYLMORPHOLINE
- Product Name
- 3(S)-HYDROXYMETHYLMORPHOLINE
- CAS No.
- 211053-50-8
- Chemical Name
- 3(S)-HYDROXYMETHYLMORPHOLINE
- Synonyms
- (3S)-3-Morpholinemethanol;(S)-morpholin-3-ylmethanol;(3S)-morpholin-3-ylmethanol;3-Morpholinemethanol, (3S)-;3(S)-HYDROXYMETHYLMORPHOLINE;(S)-3-Hydroxymethylmorpholine;(3S)-3-(Hydroxymethyl)morpholine;(3S)-3-Morpholinemethanol,99%e.e.;(3S)-3-(Hydroxymethyl)morpholine,hydrochloride(1：1)
- CBNumber
- CB9266263
- Molecular Formula
- C5H11NO2
- Formula Weight
- 117.15
- MOL File
- 211053-50-8.mol
3(S)-HYDROXYMETHYLMORPHOLINE Property
- Melting point:
- 112 °C
- Boiling point:
- 218.3±20.0 °C(Predicted)
- Density
- 1.045±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.85±0.10(Predicted)
- Appearance
- Off-white to brown Solid
Safety
- RIDADR
- 3261
- HazardClass
- 8
- PackingGroup
- Ⅲ
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H947665
- Product name
- (S)-3-Hydroxymethylmorpholine
- Packaging
- 100mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- W4406
- Product name
- 3(S)-Hydroxymethylmorpholine
- Packaging
- 100mg
- Price
- $216
- Updated
- 2021/12/16
- Product number
- 119410
- Product name
- (S)-Morpholin-3-ylmethanol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $418
- Updated
- 2021/12/16
- Product number
- AS3431-A-1S
- Product name
- (S)-3-(Hydroxymethyl)morpholine
- Purity
- 95+% ee
- Packaging
- 1g
- Price
- $358
- Updated
- 2021/12/16
- Product number
- 119410
- Product name
- (S)-Morpholin-3-ylmethanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1044
- Updated
- 2021/12/16
3(S)-HYDROXYMETHYLMORPHOLINE Chemical Properties,Usage,Production
Uses
(S)-3-Hydroxymethylmorpholine is a chemical reagent used in the synthesis of Aurora kinase inhibitors, used for their anti-tumor activity. Also used in the preparation of human epidermal growth factor receptor 1 & 2 kinase inhbitors in the treatment of solid tumors.
Synthesis
101376-25-4
211053-50-8
To a solution of (S)-(4-benzylmorpholin-3-yl)methanol (10.0 g, 48.3 mmol) in methanol (300 mL) was added 10 wt% of carbon-loaded palladium catalyst (2.0 g), and the reaction mixture was transferred to a Parr reactor. The reaction was carried out for 18 hours at room temperature under hydrogen pressure of 50 psi. Upon completion of the reaction, the mixture was filtered through a Celite pad to remove the catalyst. The filtrate was concentrated under reduced pressure to afford (S)-3-hydroxymethylmorpholine (5.2 g, 92% yield) as a colorless oil.1H NMR (CDCl3) δ: 3.81-3.76 (2H, m), 3.58-3.43 (3H, m), 3.35-3.28 (1H, m), 2.99-2.91 (5H, br.m). Mass spectrum (ES+) m/z: 118.0 ([M + H]+).
References
[1] Patent: WO2008/47109, 2008, A1. Location in patent: Page/Page column 41
[2] Patent: WO2009/1089, 2008, A1. Location in patent: Page/Page column 29-30
[3] Patent: WO2009/71895, 2009, A1. Location in patent: Page/Page column 110
[4] Patent: US2011/3785, 2011, A1. Location in patent: Page/Page column 11
[5] Patent: WO2006/114606, 2006, A1. Location in patent: Page/Page column 78
3(S)-HYDROXYMETHYLMORPHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3(S)-HYDROXYMETHYLMORPHOLINE manufacturers
- Product
- 3(S)-HYDROXYMETHYLMORPHOLINE 211053-50-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97-99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-18