TOFOGLIFLOZIN
- Product Name
- TOFOGLIFLOZIN
- CAS No.
- 1201913-82-7
- Chemical Name
- TOFOGLIFLOZIN
- Synonyms
- Tofogliflozin Monohydrate;CSG452; CSG-452; TOFOGLIFLOZIN; CSG 452; UNII-554245W62TTOFOGLIFLOZIN [INN]; TOFOGLIFLOZIN ANYHYDROUS;Togliflozin;CSG 452(hydrate);Tofogliflozin(CSG452);Tofogliflozin (hydrate);TOFOGLIFLOZIN USP/EP/BP;Tofogliflozin anyhydrous;Tofogliflozin hydrate (1:1);Tofogliflozin Hydrate (JAN)
- CBNumber
- CB92667680
- Molecular Formula
- C22H26O6.H2O
- Formula Weight
- 404.46
- MOL File
- 1201913-82-7.mol
TOFOGLIFLOZIN Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:20): 0.05 mg/ml
- form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 23509
- Product name
- Tofogliflozin (hydrate)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23509
- Product name
- Tofogliflozin (hydrate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 23509
- Product name
- Tofogliflozin (hydrate)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 23509
- Product name
- Tofogliflozin (hydrate)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $420
- Updated
- 2024/03/01
- Product number
- CS-3792
- Product name
- Tofogliflozin(hydrate)
- Purity
- 98.85%
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
TOFOGLIFLOZIN Chemical Properties,Usage,Production
Description
Tofogliflozin hydrate, which is a sodium-glucose co-transporter 2 inhibitor, was approved in Japan for the treatment of type 2 diabetes at the same time as luseogliflozin hydrate (XIX). The drug was discovered by Chugai Pharmaceutical and jointly developed with Sanofi-Aventis and Kowa. Tofogliflozin hydrate reduces glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2, and plays a key role in the reuptake of glucose in the proximal tubule of the kidneys.
Synthesis
Reduction of commercially available 2-bromoterephtalic acid (268) through the use of trimethoxyborane and borane- THF proceeded in 89% yield to afford diol 269. Subjection of this compound to 2-methoxypropene (270) under acidic conditions generated bis-acetonide 271. This bromide then underwent lithium¨Chalogen exchange followed by exposure to magnesium bromide and treatment with lactone 272 (which was prepared by persilylation of commercially available (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2Hpyran- 2-one (277). This mixture was worked up with aqueous ammonium chloride and upon treatment with p-TsOH in methanol resulted in spiroacetal 273. Next, global protection of all alcohol functionalities within 273 was affected by reaction with methylchloroformate and DMAP in acetonitrile. The benzyl carbonate within 274 was selectively exchanged via Suzuki coupling with 4-ethylphenylboronic acid (275) to afford methylene dibenzyl system 276. Subsequent treatment with aqueous sodium hydroxide in methanol followed by crystallization from 1:6 acetone and water furnished the desired product tofogliflozin hydrate (XXXIV) in 75% yield.
TOFOGLIFLOZIN Preparation Products And Raw materials
Raw materials
Preparation Products
TOFOGLIFLOZIN Suppliers
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View Lastest Price from TOFOGLIFLOZIN manufacturers
- Product
- TOFOGLIFLOZIN 1201913-82-7
- Price
- US $216.00/mg
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-12-03
- Product
- TOFOGLIFLOZIN 1201913-82-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-15
- Product
- Tofogliflozin (hydrate) 1201913-82-7
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 100kg
- Release date
- 2019-12-20