ChemicalBook > CAS DataBase List > Etilefrine hydrochloride

Etilefrine hydrochloride

Product Name
Etilefrine hydrochloride
CAS No.
943-17-9
Chemical Name
Etilefrine hydrochloride
Synonyms
Epholin;Funasol;Efortil;Efotinon;Ehochlon;Circupon;Effontil;Effortil;Kertasin;Phetanol
CBNumber
CB9268575
Molecular Formula
C10H16ClNO2
Formula Weight
217.69
MOL File
943-17-9.mol
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Etilefrine hydrochloride Property

Melting point:
122 °C
storage temp. 
-20°C
solubility 
Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride
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Safety

RIDADR 
UN 2811 6.1 / PGIII
RTECS 
DO5618000
HS Code 
2922290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E2451000
Product name
Etilefrine hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
e2451000
Price
$153
Updated
2024/03/01
TRC
Product number
E932950
Product name
EtilefrinHydrochloride
Packaging
1g
Price
$400
Updated
2021/12/16
TRC
Product number
E932950
Product name
EtilefrinHydrochloride
Packaging
5g
Price
$580
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002652
Product name
ETILEFRINE HYDROCHLORIDE
Purity
95.00%
Packaging
1G
Price
$648.81
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002652
Product name
ETILEFRINE HYDROCHLORIDE
Purity
95.00%
Packaging
2.5G
Price
$852.21
Updated
2021/12/16
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Etilefrine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder or colourless crystals.

Originator

Circupon,Troponwerke,W. Germany

Uses

Adrenoceptor agonist.

Definition

ChEBI: Etilefrine hydrochloride (TN) is a member of phenols.

Manufacturing Process

30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and dissolved while warming. After heating for 1 hour under reflux, the acylation is complete. After concentrating the reaction solution, the product is precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2- (N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water, thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan- 1-one, dissolved in a 10-fold amount of water, are added dropwise at room temperature and hydrogenation is carried out until 1 mol of hydrogen has been taken up. After filtering off the catalyst, a further 3 parts of palladium/charcoal are added and hydrogenation is carried out until a further mol of hydrogen has been taken up. The catalyst is separated off and after removal of the solvent the hydrogenation product is reprecipitated from acetone/petroleum ether and from methanol/ether until it is pure according to thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2- ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.

Therapeutic Function

Tranquilizer

Etilefrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Etilefrine hydrochloride Suppliers

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View Lastest Price from Etilefrine hydrochloride manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Efortil 943-17-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99.6%
Supply Ability
100000
Release date
2024-04-25
Hong Kong Excellence Biotechnology Co., Ltd.
Product
Etilefrine hydrochloride 943-17-9
Price
US $100.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20tons
Release date
2023-10-12
Shanghai Aosiris new Material Technology Co., LTD
Product
Etilefrine hydrochloride 943-17-9
Price
US $3.00-1.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10 tons
Release date
2024-03-14

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