4-Hydroxybenzamide

Product Name: 4-Hydroxybenzamide
CAS No.: 619-57-8
Chemical Name: 4-Hydroxybenzamide
Synonyms: 4-HYDROXYBENZAMIDE;P-HYDROXYBENZAMIDE;Benzamide,p-hydroxy-;Benzamide,4-hydroxy-;4-Hydroxybenzamide>4-HYDROXYBENZAMIDE 98%;4-HYDROXYBENZAMIDE, 97+%;4-Hydroxybenzamide, 98+%;4-Hydroxy-benzoesaeure-amid;Benzamide, 4-hydroxy- (9CI)
CBNumber: CB9271791
Molecular Formula: C7H7NO2
Formula Weight: 137.14
MOL File: 619-57-8.mol

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4-Hydroxybenzamide Property

Melting point:: 161-162 °C (lit.)
Boiling point:: 345.3±25.0 °C(Predicted)
Density: 1.286±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 8.60±0.13(Predicted)
color: White to Light yellow to Dark green
BRN: 1906921
InChI: InChI=1S/C7H7NO2/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)
InChIKey: QXSAKPUBHTZHKW-UHFFFAOYSA-N
SMILES: C(N)(=O)C1=CC=C(O)C=C1
CAS DataBase Reference: 619-57-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 270253
Product name: 4-Hydroxybenzamide
Purity: 98%
Packaging: 5g
Price: $16.04
Updated: 2024/03/01

Sigma-Aldrich

Product number: 270253
Product name: 4-Hydroxybenzamide
Purity: 98%
Packaging: 25g
Price: $105.6
Updated: 2024/03/01

TCI Chemical

Product number: H0200
Product name: 4-Hydroxybenzamide
Purity: >98.0%(N)
Packaging: 5g
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: H0200
Product name: 4-Hydroxybenzamide
Purity: >98.0%(N)
Packaging: 25g
Price: $108
Updated: 2024/03/01

Alfa Aesar

Product number: B24222
Product name: 4-Hydroxybenzamide, 98+%
Packaging: 5g
Price: $31.65
Updated: 2024/03/01

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4-Hydroxybenzamide Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

4-Hydroxybenzamide is a secondary metabolite from marine sponge Phakellia fusca.

Uses

4-Hydroxybenzamide was used in the synthesis of balanol, a potent protein kinase C (PKC) inhibitor.

Definition

4-Hydroxybenzamide (4HBM) is an important biological active compound that has the presence of various biological activities such as antimycobacterial, antifungal, antimicrobial, herbicidal, and antioxidant. The benzamide derivatives are also used in medical, pharmaceutical, and therapeutic applications because of their anti-inflammatory, antibacterial, and antifungal activities. The amine and carboxylic acids are important functional groups of present molecules. These are mainly utilized in the field of chemical industry. The cocrystallization of itraconazole (a very slightly soluble triazole antifungal drug) with 4-hydroxybenzamide (4OHBZA) can potentially increase the drug solubility at pH1.2 and 37 °C by 64 times[1-2].

References

[1] Ramesh P, et al. Theoretical and experimental spectroscopic studies of monomeric and dimeric structures of 4-hydroxybenzamide International Journal of Pharmaceutics. Journal of Molecular Structure, 2020; 1206: 127742.
[2] Vasilev N, et al. Novel cocrystals of itraconazole: Insights from phase diagrams, formation thermodynamics and solubility. International Journal of Pharmaceutics, 2021; 599: 120441.

Synthesis Reference(s)

Tetrahedron Letters, 19, p. 5183, 1978 DOI: 10.1016/S0040-4039(01)85844-5

General Description

The standard molar enthalpy of formation of 4-hydroxybenzamide was studied by micro- or macrocombustion calorimetry.

Source

4-Hydroxybenzamide is a natural product found in Oxytropis falcata, Houttuynia cordata, and Streptomyces tendae with data available.

4-Hydroxybenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxybenzamide Suppliers

Americas 1 Belgium 2 CHINA 118 Czech Republic 1 Europe 2 Germany 7 India 24 Japan 2 Slovakia 1 Switzerland 5 Ukraine 1 United Kingdom 16 United States 37 Global 217

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View Lastest Price from 4-Hydroxybenzamide manufacturers

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: 4-Hydroxybenzamide 619-57-8
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-07

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: 4-Hydroxybenzamide 619-57-8
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-07

Career Henan Chemical Co

Product: 4-Hydroxybenzamide 619-57-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-02

619-57-8, 4-HydroxybenzamideRelated Search:

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Benzamide,4-hydroxy-

Benzamide,p-hydroxy-

P-HYDROXYBENZAMIDE

4-HYDROXYBENZAMIDE

4-HYDROXYBENZAMIDE (P-HYDROXYBENZAMIDE)

Benzamide, 4-hydroxy- (9CI)

4-HYDROXYBENZAMIDE 98%

4-Hydroxybenzamide, 98+%

4-HYDROXYBENZAMIDE, 97+%

4-Hydroxy-benzoesaeure-amid

4-Hydroxybenzamide&gt

619-57-8

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AMIDE

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts