ChemicalBook > CAS DataBase List > (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride

Product Name
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
CAS No.
149690-12-0
Chemical Name
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
Synonyms
Sacubitril Impurity 9 HCl;AHU09;LCZ698;LCZ696-5;LCZ696M-01;4S)-ethyl 5-([1;LCZ-696 Impurity 34;LCZ696 Intermediate2;LCZ-696-005-2R4S-HCl;LCZ696 impurities122
CBNumber
CB92723689
Molecular Formula
C20H26ClNO2
Formula Weight
347.88
MOL File
149690-12-0.mol
More
Less

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride Property

Melting point:
155 - 162°C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
InChI
InChI=1/C20H25NO2.ClH/c1-3-23-20(22)15(2)13-19(21)14-16-9-11-18(12-10-16)17-7-5-4-6-8-17;/h4-12,15,19H,3,13-14,21H2,1-2H3;1H/t15-,19+;/s3
InChIKey
MYJTZLYRAWUSLB-MTPCZXHRNA-N
SMILES
C(C1C=CC(C2C=CC=CC=2)=CC=1)[C@@H](N)C[C@@H](C)C(=O)OCC.Cl |&1:13,16,r|
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
A601540
Product name
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoicAcidEthylEsterHydrochloride
Packaging
50mg
Price
$95
Updated
2021/12/16
AK Scientific
Product number
2498DC
Product name
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoicacidethylesterhydrochloride
Packaging
25g
Price
$870
Updated
2021/12/16
Ambeed
Product number
A249066
Product name
(2R,4S)-Ethyl5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoatehydrochloride
Purity
95%
Packaging
100g
Price
$1192
Updated
2021/12/16
Chemenu
Product number
CM244548
Product name
(2R,4S)-Ethyl5-([1,1''-biphenyl]-4-yl)-4-amino-2-methylpentanoatehydrochloride
Purity
95+%
Packaging
1000g
Price
$1748
Updated
2021/12/16
Labseeker
Product number
SC-94988
Product name
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoicacidethylesterhydrochloride
Purity
98
Packaging
1kg
Price
$21666
Updated
2021/12/16
More
Less

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride Chemical Properties,Usage,Production

Uses

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases.

Application

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a Sacubitril intermediate.

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride Suppliers

Jiangsu Vcare PharmaTech Co., Ltd.
Tel
13327700685
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
Country
China
ProdList
310
Advantage
61
Kaixin Chemical (Hong Kong) Limited
Tel
010-88886666-01 13112345678
Fax
CDXH21@126.com
Email
loyson@tcypharm.com
Country
China
ProdList
595
Advantage
55
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Boc Chemical Co.,Ltd
Tel
021-34975603-808 18721111801
Fax
+86-21-34975602-805
Email
sales@bocpharma.com
Country
China
ProdList
997
Advantage
64
Changzhou Joyous Chemical Co., Ltd.
Tel
0519-85607258
Fax
0519-85607278
Email
sales@joyouschem.com
Country
China
ProdList
294
Advantage
60
Anhui Shite Pharmaceutical Technology Co., LTD
Tel
0555-8228058 13621628489
Fax
0512-63261912
Email
sales1@stepuppharm.com
Country
China
ProdList
229
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-010-52878169 15801002657
Email
sales@bjcomparison.com
Country
China
ProdList
5004
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
13901585132
Fax
+86-25-52131256
Email
799750417@qq.com
Country
China
ProdList
8878
Advantage
55
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
977
Advantage
58
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Zhengzhou Topcare Pharmaceutical Co.,Ltd.
Tel
0371-60942985
Fax
0371-60942986,qq1994339443
Country
China
ProdList
54
Advantage
58
Changzhou Renaissance Chem Co. Ltd
Tel
86-519-86202821
Fax
Email: sales@rosewellchem.com
Country
China
ProdList
116
Advantage
56
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10274
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11578
Advantage
59
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-66023220 0086-15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7850
Advantage
55
FarmaSino Pharmaceuticals (Anhui) Co.,Ltd.
Tel
+86-18512541987
Fax
0555-5963572
Email
hll@farmasino.com
Country
China
ProdList
241
Advantage
60
Hangzhou Cheminspire Technology Co., Ltd.
Tel
0571-89081561; 10006559855
Fax
0571 89081561
Email
info@cheminspire.com
Country
China
ProdList
412
Advantage
58
PharmaSea Pharmaceutical Tech.
Tel
010-52980412
Fax
010-52980412
Email
chemsales@pharmasea.com.cn
Country
China
ProdList
49
Advantage
58
Changzhou Fang Nan Medical Technology Co., Ltd.
Tel
0519-85283268
Country
China
ProdList
116
Advantage
55
DebyeTec.com Inc.
Tel
18086626237 18086626237
Fax
qq:2693528373
Email
sales@debyesci.com
Country
China
ProdList
2645
Advantage
56
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
Advantage
55
Suzhou PengXu PharmaTech Co., Ltd.
Tel
15850786624
Email
sales@cqpharm.com
Country
China
ProdList
88
Advantage
58
INTERCHEMIE NANJING PHARMATECH CO., LTD
Tel
13656237714 13656237714
Fax
0512-65852853
Email
xiaokunfu@kyyykj.com
Country
China
ProdList
295
Advantage
55
Shanghai Bocimed Pharmaceutical Co., Ltd.
Tel
+86(21)5895-0312
Email
sales@bocimed.com
Country
China
ProdList
51
Advantage
55
Shanghai Rochi Pharmaceutical Co., Ltd.
Tel
021-38751876 15000076078
Fax
021-50275764
Email
Info@rochipharma.com
Country
China
ProdList
568
Advantage
55
Shanghai BLT Biological Pharmaceutical Co., Ltd.
Tel
021-20786057 18918495077
Fax
021-20786057
Email
3116390381@qq.com
Country
China
ProdList
220
Advantage
58
ZheJiang Hongkang Pharmaceutical Chemical Co., Ltd.
Tel
0575-83227888 18958581191
Fax
0575-83051164
Email
yrd668@163.com 33137447@qq.com
Country
China
ProdList
12
Advantage
55
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
1933
Advantage
55
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-83991130 18627774460
Fax
027-83991130
Email
1718093273@QQ.COM
Country
China
ProdList
1880
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Jiangsu C-jun Biotechnology Co., Ltd.
Tel
+86 (519) 8969-7536
Fax
+86 (519) 8988-9226
Email
sales3@cjxrpharm.com
Country
China
ProdList
217
Advantage
58
Shanghai YiWen Pharmaceutical Co., Ltd.
Tel
13621628489
Email
1322392736@qq.com
Country
China
ProdList
263
Advantage
58
Shanghai XingTai Pharmaceutical Technology co., LTD
Tel
15801747407
Fax
+86 021 51388225
Email
sales01@suntechpharma.com
Country
China
ProdList
123
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-50664929, 13971561712
Fax
027-50664927 / QQ: 3452835437
Email
hubxys2001@163.com
Country
China
ProdList
1437
Advantage
55
Henan Anky Chemical Technology Co., Ltd.
Tel
17836913271
Fax
0374-8348899
Email
3224305243@qq.com
Country
China
ProdList
2920
Advantage
58
Shanghai Elestone Pharmaceutical Technology Co., Ltd.
Tel
021-36680027/1762825045
Email
sales2@elestone.com.cn
Country
China
ProdList
296
Advantage
58
Jinan Baozhao Pharmaceutical Technology Co., Ltd.
Tel
0531-82371868 13210529039
Fax
0531-82371858
Email
baozhaopharm@163.com
Country
China
ProdList
141
Advantage
58
Beijing Xiuzheng Innovation Medicine Research Institute Co.,Ltd.
Tel
010-61765302
Fax
010-61765009
Email
wang_dz@163.com
Country
CHINA
ProdList
56
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-(0)57185586718 +86-13336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29791
Advantage
60
XinYao(Shenzhen) Biological Technology Co., Ltd.
Tel
0755-89880280
Fax
0755-89880280
Email
3004662104@qq.com
Country
China
ProdList
1829
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25004
Advantage
58
Shanghai Bojing Chemical Co., Ltd
Tel
021-37199966 13681836088
Fax
021-37597788
Email
bj@bj-chem.com
Country
China
ProdList
463
Advantage
58
More
Less

View Lastest Price from (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
LCZ696(valsartan + sacubitril) impurity 55(Hydrochloride) 149690-12-0
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-25
Career Henan Chemical Co
Product
(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate 149690-12-0
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-07-27

149690-12-0, (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester HydrochlorideRelated Search:


  • (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate HCl
  • LCZ696 Intermediate2
  • LCZ698
  • [1,1'-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride (1:1), (αR,γS)-
  • (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate
  • (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate hydrochloride
  • (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride
  • (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride (1:1)
  • acubitril Impurity 9 HCl
  • (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride149690-12-0
  • (2R, 4S) - ethyl 5- ([1,1'- biphenyl]-4- group) -4- amino -2- methyl valerate hydrochloride
  • LCZ-696 Impurity 34
  • AHU09
  • Sacubitril Impurity 9 HCl
  • LCZ-696-005-2R4S-HCl
  • Sacubitril Impurity 26
  • LCZ696M-01
  • LCZ696(valsartan + sacubitril) impurity 5
  • (2R,4S)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate HCl salt
  • 1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride
  • 4S)-ethyl 5-([1
  • LCZ696-5
  • Ethyl (2R,4S)-5-(4-Biphenylyl)-4-amino-2-methylpentanoate Hydrochloride
  • 1,1'-Biphenyl]-4-pentanoicacid,γ-amino-α-methyl-,ethylester,(αR,γS)-,hydrochloride(1:1)
  • ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride
  • (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpenta...
  • LCZ696 impurities122
  • ethyl (2R,4S)-4-amino-5-{[1,1'-biphenyl]-4-yl}-2-methylp entanoate hydrochloride
  • (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino
  • Benzene,1-methoxy-2-methyl-5-nitro-
  • (2R,4S)-Ethyl 4-amino-5-(biphenyl -4-yl)-2-methylpentanoate hydrochloride
  • Sacubitril Impurity 35 HCl
  • Sacubitril Impurity 26 Hydrochloride
  • SACUBITRIL SAV-3 (AMINE ESTER)
  • Salcubatra calcium impurity D
  • LCZ696 Intermediate 3
  • Sacubitril intermediates(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride
  • (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride
  • (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate
  • Sacubitril Impurity 3 HCl
  • Olaquindox Impurity 4
  • LCZ-696 Impurity 5 HCl
  • Sacubitril Impurity 5 HCl
  • LCZ696(valsartan + sacubitril) impurity 55(Hydrochloride)
  • 149690-12-0
  • LCZ696
  • 149690-12-0