CID-49830258
- Product Name
- CID-49830258
- CAS No.
- 1346527-98-7
- Chemical Name
- CID-49830258
- Synonyms
- ML240;CS-2775;ML240, >98%;CID-49830258;ML240 >=98% (HPLC);Cdc48,inhibit,VCP,Inhibitor,ML240,ML 240,ML-240,p97;2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine;2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-
- CBNumber
- CB92751093
- Molecular Formula
- C23H20N6O
- Formula Weight
- 396.44
- MOL File
- 1346527-98-7.mol
CID-49830258 Property
- Boiling point:
- 696.6±65.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- pka
- 4.53±0.10(Predicted)
- color
- white to yellow to light brown
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML1071
- Product name
- ML240
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- SML1071
- Product name
- ML240
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $535
- Updated
- 2024/03/01
- Product number
- 17373
- Product name
- ML-240
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 17373
- Product name
- ML-240
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 17373
- Product name
- ML-240
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $168
- Updated
- 2024/03/01
CID-49830258 Chemical Properties,Usage,Production
Uses
ML 240 is a p97 inhibitor in cancer and neurodegenerative diseases.
Uses
ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein.
Definition
ChEBI: ML240 is a member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). It has a role as an antineoplastic agent. It is a member of quinazolines, a member of benzimidazoles, a secondary amino compound, an aromatic amine, an aromatic ether and a primary amino compound.
Biochem/physiol Actions
ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines.
storage
Store at +4°C
CID-49830258 Preparation Products And Raw materials
Raw materials
Preparation Products
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