ChemicalBook > CAS DataBase List > CID-49830258

CID-49830258

Product Name
CID-49830258
CAS No.
1346527-98-7
Chemical Name
CID-49830258
Synonyms
ML240;CS-2775;ML240, >98%;CID-49830258;ML240 >=98% (HPLC);Cdc48,inhibit,VCP,Inhibitor,ML240,ML 240,ML-240,p97;2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine;2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-
CBNumber
CB92751093
Molecular Formula
C23H20N6O
Formula Weight
396.44
MOL File
1346527-98-7.mol
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CID-49830258 Property

Boiling point:
696.6±65.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
pka
4.53±0.10(Predicted)
color 
white to yellow to light brown
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1071
Product name
ML240
Purity
≥98% (HPLC)
Packaging
5mg
Price
$81
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1071
Product name
ML240
Purity
≥98% (HPLC)
Packaging
25mg
Price
$535
Updated
2024/03/01
Cayman Chemical
Product number
17373
Product name
ML-240
Purity
≥95%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
17373
Product name
ML-240
Purity
≥95%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
17373
Product name
ML-240
Purity
≥95%
Packaging
10mg
Price
$168
Updated
2024/03/01
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CID-49830258 Chemical Properties,Usage,Production

Uses

ML 240 is a p97 inhibitor in cancer and neurodegenerative diseases.

Uses

ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein.

Definition

ChEBI: ML240 is a member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). It has a role as an antineoplastic agent. It is a member of quinazolines, a member of benzimidazoles, a secondary amino compound, an aromatic amine, an aromatic ether and a primary amino compound.

Biochem/physiol Actions

ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines.

storage

Store at +4°C

CID-49830258 Preparation Products And Raw materials

Raw materials

Preparation Products

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CID-49830258 Suppliers

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1346527-98-7, CID-49830258Related Search:

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264

  • 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
  • CS-2775
  • ML240, >98%
  • 2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
  • CID-49830258
  • ML240
  • 2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine
  • 4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-
  • ML240 >=98% (HPLC)
  • Cdc48,inhibit,VCP,Inhibitor,ML240,ML 240,ML-240,p97
  • 1346527-98-7
  • API