CID-49830258
- Product Name
- CID-49830258
- CAS No.
- 1346527-98-7
- Chemical Name
- CID-49830258
- Synonyms
- ML240;CS-2775;ML240, >98%;CID-49830258;ML240 >=98% (HPLC);Cdc48,inhibit,VCP,Inhibitor,ML240,ML 240,ML-240,p97;2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine;2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-
- CBNumber
- CB92751093
- Molecular Formula
- C23H20N6O
- Formula Weight
- 396.44
- MOL File
- 1346527-98-7.mol
CID-49830258 Property
- Boiling point:
- 696.6±65.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- pka
- 4.53±0.10(Predicted)
- color
- white to yellow to light brown
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML1071
- Product name
- ML240
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- SML1071
- Product name
- ML240
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $535
- Updated
- 2024/03/01
- Product number
- 17373
- Product name
- ML-240
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 17373
- Product name
- ML-240
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 17373
- Product name
- ML-240
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $168
- Updated
- 2024/03/01
CID-49830258 Chemical Properties,Usage,Production
Uses
ML 240 is a p97 inhibitor in cancer and neurodegenerative diseases.
Uses
ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein.
Definition
ChEBI: ML240 is a member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). It has a role as an antineoplastic agent. It is a member of quinazolines, a member of benzimidazoles, a secondary amino compound, an aromatic amine, an aromatic ether and a primary amino compound.
Biochem/physiol Actions
ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines.
storage
Store at +4°C
CID-49830258 Preparation Products And Raw materials
Raw materials
Preparation Products
CID-49830258 Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4307
- Advantage
- 58
- Tel
- 13621943973
- Fax
- -
- sales@shjiyipharmatech.com
- Country
- China
- ProdList
- 1166
- Advantage
- 55
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4512
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2992
- Advantage
- 58
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 7267
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58