ChemicalBook > CAS DataBase List > 3,4-Difluorobenzaldehyde

3,4-Difluorobenzaldehyde

Product Name
3,4-Difluorobenzaldehyde
CAS No.
34036-07-2
Chemical Name
3,4-Difluorobenzaldehyde
Synonyms
3,4-Difluorobenzalde;3,4-fluorobenzaldehyde;3,4-Difluorbenzaldehyd;3,4-DIFLUOROBENZALDEHYDE;3,4-DIFLOUROBENZALDEHYDE;3,6-Difluoroacetophenone;3, 4-2 fluoro benzaldehyde;3,4-Difluorobenzaldehyde>Benzaldehyde, 3,4-difluoro-;3,4-Difluorobenzaldehyde 98%
CBNumber
CB9275911
Molecular Formula
C7H4F2O
Formula Weight
142.1
MOL File
34036-07-2.mol
More
Less

3,4-Difluorobenzaldehyde Property

Boiling point:
53-55°C (15 mmHg)
Density 
1.288 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.5(lit.)
Flash point:
150 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
3.962g/l
form 
Liquid
Specific Gravity
1.288
color 
Clear colorless to yellow
Sensitive 
Air Sensitive
BRN 
2241231
InChI
InChI=1S/C7H4F2O/c8-6-2-1-5(4-10)3-7(6)9/h1-4H
InChIKey
JPHKMYXKNKLNDF-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(F)C(F)=C1
CAS DataBase Reference
34036-07-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39-36/37
WGK Germany 
2
F 
10-21
HazardClass 
IRRITANT
HS Code 
29124990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
265160
Product name
3,4-Difluorobenzaldehyde
Purity
97%
Packaging
5g
Price
$49.4
Updated
2025/07/31
Sigma-Aldrich
Product number
265160
Product name
3,4-Difluorobenzaldehyde
Purity
97%
Packaging
25g
Price
$114.1
Updated
2025/07/31
TCI Chemical
Product number
D2340
Product name
3,4-Difluorobenzaldehyde
Purity
>97.0%(GC)
Packaging
5g
Price
$53
Updated
2025/07/31
TCI Chemical
Product number
D2340
Product name
3,4-Difluorobenzaldehyde
Purity
>97.0%(GC)
Packaging
25g
Price
$139
Updated
2025/07/31
TRC
Product number
D445680
Product name
3,4-Difluorobenzaldehyde
Packaging
5g
Price
$55
Updated
2021/12/16
More
Less

3,4-Difluorobenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Clear Liquid

Uses

3,4-Difluorobenzaldehyde is used in the synthesis of fluorine-substituted analogs of Curcumin (C838500), as chemopreventive and/or therapeutic agents against cancers and/or against the development of drug-resistant cancer.

Uses

3,4-Difluorobenzaldehyde was used in the synthesis of 3-benzylidene 20,29-dihydrobetulinic acid derivatives.

Uses

Metabolic

Synthesis

75-29-6

348-61-8

68-12-2

34036-07-2

General procedure: a 5L four-necked flask is equipped with a mechanical stirring device and protected by nitrogen gas. Magnesium strips and 400 g of iodine granules were added sequentially in tetrahydrofuran. 41.7g of 2-chloropropane was slowly added at room temperature, and the addition time was controlled within 10 minutes, and then the reaction was warmed up to 40℃. The reaction was cooled to room temperature upon completion. A tetrahydrofuran solution of 3,4-difluorobromobenzene (654 g of 3,4-difluorobromobenzene dissolved in 700 g of tetrahydrofuran) was added dropwise at 0 to 10 °C, with the dropwise addition time controlled within 50 min. After the dropwise addition, the reaction mixture was kept at room temperature. After completion of the reaction it was again cooled to 0-10°C and a tetrahydrofuran solution of N,N-dimethylformamide (DMF) was added dropwise (291.3 g of DMF dissolved in 300 g of tetrahydrofuran) over a period of 40 min, keeping the temperature below 10°C. Subsequently 700 g of water was added dropwise and the pH was adjusted to about 4 with concentrated hydrochloric acid (about 840 g of hydrochloric acid was required). Phase separation was carried out and the aqueous phase was extracted twice with 500 g of toluene to combine the organic layers. The organic layer was sequentially washed once with 500 g of saturated saline and once more with 500 g of water. Finally, the crude product was concentrated under vacuum at 65 °C to no solvent. The crude product was purified by vacuum distillation to obtain 3,4-difluorobenzaldehyde with a purity greater than 99.5% and a yield of 86%.

References

[1] Patent: CN105859536, 2016, A. Location in patent: Paragraph 0016; 0017

3,4-Difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

trans-3,4-Difluorocinnamic acid
More
Less

3,4-Difluorobenzaldehyde Suppliers

Americas 1 Belgium 2 Canada 4 China 331 Europe 3 France 2 Germany 5 India 20 Italy 1 Japan 5 Jordan 1 Poland 1 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 2 United Kingdom 25 United States 47 Global 455
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
SynQuest Laboratories, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
2301
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Interchem Corporation USA
Tel
--
Fax
--
Email
esa@interchem.com
Country
United States
ProdList
469
Advantage
58
Brightek LLC
Tel
--
Fax
--
Country
United States
ProdList
782
Advantage
58
Tyger Scientific Inc.
Tel
--
Fax
--
Email
sales@tygersci.com
Country
United States
ProdList
402
Advantage
58
AOBChem
Tel
--
Fax
--
Email
sales@aobchem.com
Country
United States
ProdList
885
Advantage
58
Bridge Organics Company
Tel
--
Fax
--
Email
businessoffice@bridgeorganics.com
Country
United States
ProdList
85
Advantage
58
Bridge Organics Co.,
Tel
--
Fax
--
Country
United States
ProdList
63
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Daniel Lab Canada
Tel
--
Fax
--
Country
United States
ProdList
273
Advantage
50
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
AOBChem USA
Tel
--
Fax
--
Email
sales@aobchem.com
Country
United States
ProdList
3487
Advantage
50
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
Fine Chem Trading LTD
Tel
--
Fax
--
Email
chemfinder@chemfinder.co.uk
Country
United States
ProdList
1609
Advantage
64
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Accord Corporation
Tel
--
Fax
--
Email
info@accordchem.com
Country
United States
ProdList
225
Advantage
42
Kingchem Inc.
Tel
--
Fax
--
Email
s.wang@kingchem.com
Country
United States
ProdList
757
Advantage
60
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
AB Chem Technologies, LLC
Tel
--
Fax
--
Email
sales@abchemtech.com
Country
United States
ProdList
1101
Advantage
46
Marshallton Research Laboratories Inc.
Tel
--
Fax
--
Email
marshallton@windstream.net
Country
United States
ProdList
513
Advantage
59
Honeywell Specialty Chemicals Seelze GmbH
Tel
--
Fax
--
Email
ofc@honeywell.com
Country
United States
ProdList
639
Advantage
87
AcceleDev Chemical LLC
Tel
--
Fax
--
Email
info@acceledev.com
Country
United States
ProdList
632
Advantage
42
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Chontech, Inc.
Tel
--
Fax
--
Email
chontech@yahoo.com
Country
United States
ProdList
1101
Advantage
30
More
Less

View Lastest Price from 3,4-Difluorobenzaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3,4-Difluorobenzaldehyde 34036-07-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-26
Hebei Zhuanglai Chemical Trading Co Ltd
Product
3,4-Difluorobenzaldehyde 34036-07-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-28
Henan Aochuang Chemical Co.,Ltd.
Product
3,4-Difluorobenzaldehyde 34036-07-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10

34036-07-2, 3,4-DifluorobenzaldehydeRelated Search:

3,4-Difluorobenzoic acid Tetrafluorophthalic acid 2,3,4,5-Tetrafluorobenzoic acid DECAFLUOROBENZOPHENONE METHYL PENTAFLUOROBENZOATE ETHYL PENTAFLUOROBENZOATE Pentafluorobenzoic acid 3,4-Difluorobenzophenone 3',4'-DIFLUOROPROPIOPHENONE 3,4-Difluorobenzoyl chloride 3',4'-Difluoroacetophenone Pentafluorobenzoyl chloride N-PENTAFLUOROBENZOYLIMIDAZOLE 2,3,4,5,6-PENTAFLUOROBENZOPHENONE 2,3,4,5,6-PENTAFLUOROBENZAMIDE 3,4-DIFLUOROBENZAMIDE 2,4,5-Trifluorobenzoic acid 2',3',4',5',6'-PENTAFLUOROACETOPHENONE

  • 3,4-DIFLUOROBENZALDEHYDE
  • 3,4-Difluorobenzaldehyde,98%
  • 3,4-Difluorobenzaldehyde 98%
  • 3,4-Difluorbenzaldehyd
  • 3,4-Difluorobenzalde
  • 1,3-DiFluorobenzenebenzaldehyde
  • 3,4-fluorobenzaldehyde
  • 3,4-Difluorobenzaldehyde, 96% 25GR
  • 3,4-Difluorobenzaldehyde, 96% 5GR
  • 3,4-Difluorobenzaldehyde,96%
  • 3,4-DIFLUOROBENZALDEHYDE FOR SYNTHESIS
  • 3, 4-2 fluoro benzaldehyde
  • 3,4-Difluorobenzaldehyde&gt
  • 3,4-Difluorobenzaldehyde,>97%
  • Benzaldehyde, 3,4-difluoro-
  • 3,4-Difluorobenzaldehyde ISO 9001：2015 REACH
  • <font color="#ff0000">34036-07-2</font>
  • 3,4-DIFLOUROBENZALDEHYDE
  • 3,6-Difluoroacetophenone
  • 34036-07-2
  • 3403-60-7
  • C7H4F2O
  • Organic Building Blocks
  • Carbonyl Compounds
  • C7
  • Building Blocks
  • Aldehydes
  • Benzaldehyde series
  • Aromatic Aldehydes & Derivatives (substituted)
  • Benzaldehyde
  • Miscellaneous
  • Aromatics
  • Aldehydes
  • C7
  • Carbonyl Compounds
  • Fluoro-Aromatics
  • Fluorin-contained benzaldehyde series
  • bc0001