ChemicalBook > CAS DataBase List > 4-Bromo-2-fluoroanisole

4-Bromo-2-fluoroanisole

Product Name
4-Bromo-2-fluoroanisole
CAS No.
2357-52-0
Chemical Name
4-Bromo-2-fluoroanisole
Synonyms
4-Bromo-2-fluoro-1-methoxybenzene;4-Bromo-2-fluoroanis;4-Cyano-fluoro phenol;Fluoro-4-bromoanisole;2-Fluoro-4-Bromo Anisol;4-BROMO-2-FLUOROANISOLE;2-FLUORO-4-BROMOANISOLE;4-Bromo-2-fluoroanisole98%;4-Bromo-2-fluoroanisole>4-Bromo-2-fluoroanisole 98%
CBNumber
CB9282221
Molecular Formula
C7H6BrFO
Formula Weight
205.02
MOL File
2357-52-0.mol
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4-Bromo-2-fluoroanisole Property

Melting point:
16 °C
Boiling point:
84 °C/7 mmHg (lit.)
Density 
1.59 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.545(lit.)
Flash point:
209 °F
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Light yellow
Specific Gravity
1.590
Water Solubility 
insoluble
BRN 
3240714
InChI
InChI=1S/C7H6BrFO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H3
InChIKey
DWNXGZBXFDNKOR-UHFFFAOYSA-N
SMILES
C1(OC)=CC=C(Br)C=C1F
CAS DataBase Reference
2357-52-0(CAS DataBase Reference)
NIST Chemistry Reference
4-Bromo-2-fluoroanisole(2357-52-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
293474
Product name
4-Bromo-2-fluoroanisole
Purity
97%
Packaging
5g
Price
$52.1
Updated
2023/06/20
TCI Chemical
Product number
B1855
Product name
4-Bromo-2-fluoroanisole
Purity
>98.0%(GC)
Packaging
5g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
B1855
Product name
4-Bromo-2-fluoroanisole
Purity
>98.0%(GC)
Packaging
25g
Price
$127
Updated
2025/07/31
TRC
Product number
B691898
Product name
4-Bromo-2-fluoroanisole
Packaging
1g
Price
$55
Updated
2021/12/16
SynQuest Laboratories
Product number
2607-B-04
Product name
4-Bromo-2-fluoroanisole
Purity
98%
Packaging
100g
Price
$75
Updated
2021/12/16
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4-Bromo-2-fluoroanisole Chemical Properties,Usage,Production

Chemical Properties

CLEAR VERY SLIGHTLY YELLOW LIQUID

Uses

4-Bromo-2-fluoroanisole has been used in the synthesis of:

  • 1,4-bis[(3′-fluoro-4′-n alkoxyphenyl)ethynyl]benzenes with n=1-12
  • 7-fluoro-6-methoxy-1-methyl-2-naphthaldehyde
  • 5,7-difluoro-6-methoxy-1-methyl-2-naphthaldehyde
  • liquid crystals with terminal difluoromethoxy group and backbone of phenylbicyclohexane

General Description

The IR and FT-IR spectra of 4-bromo-2-fluoroanisole have been investigated.

Synthesis

321-28-8

2357-52-0

(a) Synthesis of 2-fluoro-4-bromoanisole: Add 128 g (1.016 mol) of 2-fluoroanisole and 250 ml of chloroform to the reaction vessel. Under stirring conditions at room temperature, 177 g (1.106 mol) of bromine was slowly added dropwise for not less than 3 hours. Upon completion of the reaction, the reaction mixture was poured into dilute aqueous sodium hydroxide solution to separate the chloroform layer. The chloroform layer was subsequently washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. The solvent was removed by distillation and the residue was distilled under reduced pressure to give 2-fluoro-4-bromoanisole. The yield was 192 g (yield: 92.3%) and the boiling point was 107°-116°C (25-31 mmHg).

References

[1] Journal of Organic Chemistry, 2018, vol. 83, # 2, p. 930 - 938
[2] Patent: US5098602, 1992, A
[3] Helvetica Chimica Acta, 1984, vol. 67, p. 1572 - 1579
[4] Patent: US5397504, 1995, A
[5] Patent: US4997942, 1991, A

4-Bromo-2-fluoroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-fluoroanisole Suppliers

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View Lastest Price from 4-Bromo-2-fluoroanisole manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-Bromo-2-fluoroanisole 2357-52-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-05-23
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Bromo-2-fluoroanisole 2357-52-0
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
Hebei Yanxi Chemical Co., Ltd.
Product
4-Bromo-2-fluoroanisole 2357-52-0
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-23

2357-52-0, 4-Bromo-2-fluoroanisole Related Search:

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  • Organic Building Blocks
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  • Oxygen Compounds
  • ARYL HALIDE
  • Building Blocks
  • Aromatic Halides (substituted)
  • AnisoleSeries
  • Anisole
  • Miscellaneous
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  • Bromine Compounds
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  • Benzenes
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