4-Bromo-2-fluoroanisole
- Product Name
- 4-Bromo-2-fluoroanisole
- CAS No.
- 2357-52-0
- Chemical Name
- 4-Bromo-2-fluoroanisole
- Synonyms
- 4-Bromo-2-fluoro-1-methoxybenzene;4-Bromo-2-fluoroanis;4-Cyano-fluoro phenol;Fluoro-4-bromoanisole;2-Fluoro-4-Bromo Anisol;4-BROMO-2-FLUOROANISOLE;2-FLUORO-4-BROMOANISOLE;4-Bromo-2-fluoroanisole98%;4-Bromo-2-fluoroanisole>4-Bromo-2-fluoroanisole 98%
- CBNumber
- CB9282221
- Molecular Formula
- C7H6BrFO
- Formula Weight
- 205.02
- MOL File
- 2357-52-0.mol
4-Bromo-2-fluoroanisole Property
- Melting point:
- 16 °C
- Boiling point:
- 84 °C/7 mmHg (lit.)
- Density
- 1.59 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.545(lit.)
- Flash point:
- 209 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow
- Specific Gravity
- 1.590
- Water Solubility
- insoluble
- BRN
- 3240714
- InChI
- InChI=1S/C7H6BrFO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H3
- InChIKey
- DWNXGZBXFDNKOR-UHFFFAOYSA-N
- SMILES
- C1(OC)=CC=C(Br)C=C1F
- CAS DataBase Reference
- 2357-52-0(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Bromo-2-fluoroanisole(2357-52-0)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 293474
- Product name
- 4-Bromo-2-fluoroanisole
- Purity
- 97%
- Packaging
- 5g
- Price
- $52.1
- Updated
- 2023/06/20
- Product number
- B1855
- Product name
- 4-Bromo-2-fluoroanisole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- B1855
- Product name
- 4-Bromo-2-fluoroanisole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $127
- Updated
- 2025/07/31
- Product number
- B691898
- Product name
- 4-Bromo-2-fluoroanisole
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 2607-B-04
- Product name
- 4-Bromo-2-fluoroanisole
- Purity
- 98%
- Packaging
- 100g
- Price
- $75
- Updated
- 2021/12/16
4-Bromo-2-fluoroanisole Chemical Properties,Usage,Production
Chemical Properties
CLEAR VERY SLIGHTLY YELLOW LIQUID
Uses
4-Bromo-2-fluoroanisole has been used in the synthesis of:
- 1,4-bis[(3′-fluoro-4′-n alkoxyphenyl)ethynyl]benzenes with n=1-12
- 7-fluoro-6-methoxy-1-methyl-2-naphthaldehyde
- 5,7-difluoro-6-methoxy-1-methyl-2-naphthaldehyde
- liquid crystals with terminal difluoromethoxy group and backbone of phenylbicyclohexane
General Description
The IR and FT-IR spectra of 4-bromo-2-fluoroanisole have been investigated.
Synthesis
321-28-8
2357-52-0
(a) Synthesis of 2-fluoro-4-bromoanisole: Add 128 g (1.016 mol) of 2-fluoroanisole and 250 ml of chloroform to the reaction vessel. Under stirring conditions at room temperature, 177 g (1.106 mol) of bromine was slowly added dropwise for not less than 3 hours. Upon completion of the reaction, the reaction mixture was poured into dilute aqueous sodium hydroxide solution to separate the chloroform layer. The chloroform layer was subsequently washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. The solvent was removed by distillation and the residue was distilled under reduced pressure to give 2-fluoro-4-bromoanisole. The yield was 192 g (yield: 92.3%) and the boiling point was 107°-116°C (25-31 mmHg).
References
[1] Journal of Organic Chemistry, 2018, vol. 83, # 2, p. 930 - 938
[2] Patent: US5098602, 1992, A
[3] Helvetica Chimica Acta, 1984, vol. 67, p. 1572 - 1579
[4] Patent: US5397504, 1995, A
[5] Patent: US4997942, 1991, A
4-Bromo-2-fluoroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-2-fluoroanisole Suppliers
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View Lastest Price from 4-Bromo-2-fluoroanisole manufacturers
- Product
- 4-Bromo-2-fluoroanisole 2357-52-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-23
- Product
- 4-Bromo-2-fluoroanisole 2357-52-0
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05
- Product
- 4-Bromo-2-fluoroanisole 2357-52-0
- Price
- US $30.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-10-23