3-METHYLADENINE
- Product Name
- 3-METHYLADENINE
- CAS No.
- 5142-23-4
- Chemical Name
- 3-METHYLADENINE
- Synonyms
- 109723;NSC 66389;NSC-63889;NSC 66389,3-M;3-Methyl-6-am;NSC 66389,3-MA;3-methyl-adenin;3-METHYLADENINE;N3-Methyladenine;Adenine, 3-methyl-
- CBNumber
- CB9307216
- Molecular Formula
- C6H7N5
- Formula Weight
- 149.15
- MOL File
- 5142-23-4.mol
3-METHYLADENINE Property
- Melting point:
- ~300 °C (dec.)(lit.)
- Boiling point:
- 240℃
- Density
- 1.60
- refractive index
- 1.8070 (estimate)
- Flash point:
- 99℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
- pka
- 6.77±0.20(Predicted)
- form
- Powder
- color
- White
- BRN
- 146087
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- 189490
- Product name
- Autophagy Inhibitor, 3-MA
- Packaging
- 50mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 189490
- Product name
- Autophagy Inhibitor, 3-MA
- Packaging
- 100mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- M2518
- Product name
- 3-Methyladenine
- Packaging
- 200mg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- M2518
- Product name
- 3-Methyladenine
- Packaging
- 1g
- Price
- $492
- Updated
- 2024/03/01
- Product number
- J64813
- Product name
- Autophagy Inhibitor, 3-MA
- Packaging
- 25mg
- Price
- $66.3
- Updated
- 2023/06/20
3-METHYLADENINE Chemical Properties,Usage,Production
Description
Autophagy is a multi-
Chemical Properties
White powder
Uses
A multi-use inhibitor that protects cerebellar granule cells from apoptosis.
Uses
A synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation
Uses
3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
Definition
ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.
General Description
A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
Biochem/physiol Actions
3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).
storage
+4°C
References
1) Seglen and Gordon?et al.?(1982),?3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes; Proc. Natl. Acad. Sci. USA,?79?1889 2) Blommaart?et al. (1997),?The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem.,?243?240 3) McFarland?et al. (2012),?Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity; Arch. Toxicol.,?86?275 4) Zhao?et al. (2014),?Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models; Curr. Mol. Med.,?14?555
3-METHYLADENINE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-METHYLADENINE manufacturers
- Product
- 3-METHYLADENINE 5142-23-4
- Price
- US $95.00-950.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-14
- Product
- 3-METHYLADENINE 5142-23-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2021-10-11
- Product
- 3-METHYLADENINE 5142-23-4
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23