3-METHYLADENINE

ChemicalBook > CAS DataBase List > 3-METHYLADENINE

Product Name: 3-METHYLADENINE
CAS No.: 5142-23-4
Chemical Name: 3-METHYLADENINE
Synonyms: 109723;NSC 66389;NSC-63889;NSC 66389,3-M;3-Methyl-6-am;NSC 66389,3-MA;3-methyl-adenin;3-METHYLADENINE;N3-Methyladenine;Adenine, 3-methyl-
CBNumber: CB9307216
Molecular Formula: C6H7N5
Formula Weight: 149.15
MOL File: 5142-23-4.mol

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3-METHYLADENINE Property

Melting point:: ~300 °C (dec.)(lit.)
Boiling point:: 240℃
Density: 1.60
refractive index: 1.8070 (estimate)
Flash point:: 99℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
pka: 6.77±0.20(Predicted)
form: Powder
color: White
BRN: 146087
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 3
RTECS: AU6520000
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 189490
Product name: Autophagy Inhibitor, 3-MA
Packaging: 50mg
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: 189490
Product name: Autophagy Inhibitor, 3-MA
Packaging: 100mg
Price: $159
Updated: 2024/03/01

TCI Chemical

Product number: M2518
Product name: 3-Methyladenine
Packaging: 200mg
Price: $141
Updated: 2024/03/01

TCI Chemical

Product number: M2518
Product name: 3-Methyladenine
Packaging: 1g
Price: $492
Updated: 2024/03/01

Alfa Aesar

Product number: J64813
Product name: Autophagy Inhibitor, 3-MA
Packaging: 25mg
Price: $66.3
Updated: 2023/06/20

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3-METHYLADENINE Chemical Properties,Usage,Production

Description

Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy. 3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%. 3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.

Chemical Properties

White powder

Uses

A multi-use inhibitor that protects cerebellar granule cells from apoptosis.

Uses

A synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation

Uses

3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.

Definition

ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.

General Description

A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC₅₀ = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)

Biochem/physiol Actions

3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).

storage

+4°C

References

1) Seglen and Gordon?et al.?(1982),?3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes; Proc. Natl. Acad. Sci. USA,?79?1889 2) Blommaart?et al. (1997),?The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem.,?243?240 3) McFarland?et al. (2012),?Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity; Arch. Toxicol.,?86?275 4) Zhao?et al. (2014),?Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models; Curr. Mol. Med.,?14?555

3-METHYLADENINE Preparation Products And Raw materials

Raw materials

Adenine Toluene Nickel Monoperoxyphthalic acid magnesium salt hexahydrate Benzyl bromide N,N-Dimethylacetamide Sulfuric acid Dimethyl sulfate

Preparation Products

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View Lastest Price from 3-METHYLADENINE manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 3-METHYLADENINE 5142-23-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-03

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 3-METHYLADENINE 5142-23-4
Price: US $95.00-950.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-14

Henan Fengda Chemical Co., Ltd

Product: 3-METHYLADENINE 5142-23-4
Price: US $10.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-28

5142-23-4, 3-METHYLADENINERelated Search:

5-[(4-chlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione NSC 247030 HAMNO NSC23005 Sodium NSC632839hydrochloride NSC228155 S3I-201 5-(4-iodobenzylidene)rhodanine 1,3-Bis(4-aminophenyl)urea 2-Pyridinecarbothioamide, N-2-pyridinyl- Pifithrin-μ 4-Chloro-N,N-diisopropylbenzamide 2,4-Thiazolidinedione,5-[(4-hydroxy-3-methoxyphenyl)methylene]- NSC781406 TIMTEC-BB SBB006342 4-Chloro-N,N-di-n-propylbenzaMide, 97% 4-Chloro-N,N-diethylbenzaMide, 97% 5-(2-HYDROXY-BENZYLIDENE)-THIAZOLIDINE-2,4-DIONE

3H-Purin-6-amine, 3-methyl-

3-methyl-3h-purin-6-amin

3-Methyl-3H-purin-6-amine

3-methyl-adenin

Adenine, 3-methyl-

3-METHYLADENINE

3-methyl-3H-adenine

6-AMINO-3-METHYLPURINE

Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem

109723

3-methylpurin-6-amine

3-Methyladenine, 90+%, pure

3-Methyladenine, pure

3-Methyl-6-amino-3H-purine

3-Methyladenine6-Amino-3-methylpurine

3-Methyladenine, pure, 90+%

3-Methyl-6-aminopurine

N3-Methyladenine

NSC 66389

3-MA (3-Methyl adenine)

3-methyladenine,3MA

Autophagy Inhibitor, 3-MA

NSC 66389,3-MA

3-Methyladenine, GC 90+%

NSC 66389,3-M

6-Amino-3-methylpurine 3-Methyladenine

Autophagy Inhibitor

3-Methyladenine, >=98%

Methyladenine Methyladenine

NSC-63889

3-METHYLADENINE USP/EP/BP

N3-Methyladenine/NSC 66389

3-Methyl-6-am

3-Methyladenine, selective PI3K inhibitor

5142-23-4

Building Blocks

Biochemicals and Reagents

BioChemical

Heterocyclic Building Blocks

Purines

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

Akt

mTOR

PI3K

Amines

Bases & Related Reagents

Heterocycles

Inhibitors

Nucleotides