ChemicalBook > CAS DataBase List > 3-METHYLADENINE

3-METHYLADENINE

Product Name
3-METHYLADENINE
CAS No.
5142-23-4
Chemical Name
3-METHYLADENINE
Synonyms
109723;NSC 66389;NSC-63889;NSC 66389,3-M;3-Methyl-6-am;NSC 66389,3-MA;3-methyl-adenin;3-METHYLADENINE;N3-Methyladenine;Adenine, 3-methyl-
CBNumber
CB9307216
Molecular Formula
C6H7N5
Formula Weight
149.15
MOL File
5142-23-4.mol
More
Less

3-METHYLADENINE Property

Melting point:
~300 °C (dec.)(lit.)
Boiling point:
240℃
Density 
1.60
refractive index 
1.8070 (estimate)
Flash point:
99℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
pka
6.77±0.20(Predicted)
form 
Powder
color 
White
BRN 
146087
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
3
RTECS 
AU6520000
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403Store in a well-ventilated place.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
189490
Product name
Autophagy Inhibitor, 3-MA
Packaging
50mg
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
189490
Product name
Autophagy Inhibitor, 3-MA
Packaging
100mg
Price
$159
Updated
2024/03/01
TCI Chemical
Product number
M2518
Product name
3-Methyladenine
Packaging
200mg
Price
$141
Updated
2024/03/01
TCI Chemical
Product number
M2518
Product name
3-Methyladenine
Packaging
1g
Price
$492
Updated
2024/03/01
Alfa Aesar
Product number
J64813
Product name
Autophagy Inhibitor, 3-MA
Packaging
25mg
Price
$66.3
Updated
2023/06/20
More
Less

3-METHYLADENINE Chemical Properties,Usage,Production

Description

Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy. 3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%. 3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.

Chemical Properties

White powder

Uses

A multi-use inhibitor that protects cerebellar granule cells from apoptosis.

Uses

A synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation

Uses

3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.

Definition

ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.

General Description

A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)

Biochem/physiol Actions

3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).

storage

+4°C

References

1) Seglen and Gordon?et al.?(1982),?3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes; Proc. Natl. Acad. Sci. USA,?79?1889 2) Blommaart?et al. (1997),?The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem.,?243?240 3) McFarland?et al. (2012),?Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity; Arch. Toxicol.,?86?275 4) Zhao?et al. (2014),?Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models; Curr. Mol. Med.,?14?555

3-METHYLADENINE Preparation Products And Raw materials

Raw materials

Adenine Toluene Nickel Monoperoxyphthalic acid magnesium salt hexahydrate Benzyl bromide N,N-Dimethylacetamide Sulfuric acid Dimethyl sulfate

Preparation Products

More
Less

3-METHYLADENINE Suppliers

Americas 1 Belgium 1 Canada 1 China 228 China Hong Kong 1 Europe 1 Germany 1 India 4 Japan 1 Russia 1 Switzerland 2 United Kingdom 5 United States 28 Global 275
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cambridge Isotope Laboratories, Inc.
Tel
--
Fax
--
Email
cilsales@isotope.com
Country
United States
ProdList
6598
Advantage
79
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
Abcam
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6000
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Selleck Chemicals LLC
Tel
--
Fax
--
Email
info@selleckchem.com
Country
United States
ProdList
824
Advantage
60
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
More
Less

View Lastest Price from 3-METHYLADENINE manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
3-METHYLADENINE 5142-23-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-03
Zibo Hangyu Biotechnology Development Co., Ltd
Product
3-METHYLADENINE 5142-23-4
Price
US $95.00-950.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-14
Henan Fengda Chemical Co., Ltd
Product
3-METHYLADENINE 5142-23-4
Price
US $10.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-28

5142-23-4, 3-METHYLADENINERelated Search:

5-[(4-chlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione NSC 247030 HAMNO NSC23005 Sodium NSC632839hydrochloride NSC228155 S3I-201 5-(4-iodobenzylidene)rhodanine 1,3-Bis(4-aminophenyl)urea 2-Pyridinecarbothioamide, N-2-pyridinyl- Pifithrin-μ 4-Chloro-N,N-diisopropylbenzamide 2,4-Thiazolidinedione,5-[(4-hydroxy-3-methoxyphenyl)methylene]- NSC781406 TIMTEC-BB SBB006342 4-Chloro-N,N-di-n-propylbenzaMide, 97% 4-Chloro-N,N-diethylbenzaMide, 97% 5-(2-HYDROXY-BENZYLIDENE)-THIAZOLIDINE-2,4-DIONE

  • 3H-Purin-6-amine, 3-methyl-
  • 3-methyl-3h-purin-6-amin
  • 3-Methyl-3H-purin-6-amine
  • 3-methyl-adenin
  • Adenine, 3-methyl-
  • 3-METHYLADENINE
  • 3-methyl-3H-adenine
  • 6-AMINO-3-METHYLPURINE
  • Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem
  • 109723
  • 3-methylpurin-6-amine
  • 3-Methyladenine, 90+%, pure
  • 3-Methyladenine, pure
  • 3-Methyl-6-amino-3H-purine
  • 3-Methyladenine6-Amino-3-methylpurine
  • 3-Methyladenine, pure, 90+%
  • 3-Methyl-6-aminopurine
  • N3-Methyladenine
  • NSC 66389
  • 3-MA (3-Methyl adenine)
  • 3-methyladenine,3MA
  • Autophagy Inhibitor, 3-MA
  • NSC 66389,3-MA
  • 3-Methyladenine, GC 90+%
  • NSC 66389,3-M
  • 6-Amino-3-methylpurine 3-Methyladenine
  • Autophagy Inhibitor
  • 3-Methyladenine, >=98%
  • Methyladenine Methyladenine
  • NSC-63889
  • 3-METHYLADENINE USP/EP/BP
  • N3-Methyladenine/NSC 66389
  • 3-Methyl-6-am
  • 3-Methyladenine, selective PI3K inhibitor
  • 5142-23-4
  • Building Blocks
  • Biochemicals and Reagents
  • BioChemical
  • Heterocyclic Building Blocks
  • Purines
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Akt
  • mTOR
  • PI3K
  • Amines
  • Bases & Related Reagents
  • Heterocycles
  • Inhibitors
  • Nucleotides