UNC3866
- Product Name
- UNC3866
- CAS No.
- 1872382-47-2
- Chemical Name
- UNC3866
- Synonyms
- CS-2491;UNC3866;UNC 3866;UNC-3866;UNC3866, 10 mM in DMSO;UNC3866,inhibit,Histone Methyltransferase,UNC-3866,Inhibitor,UNC 3866;N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine methyl ester;L-Serine, N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-, methyl ester;(3S,6S,9S,12S,15S)-Methyl 3-benzyl-1-(4-(tert-butyl)phenyl)-12-(4-(diethylamino)butyl)-15-(hydroxymethyl)-9-isobutyl-6-methyl-1,4,7,10,13-pentaoxo-2,5,8,11,14-pentaazahexadecan-16-oate
- CBNumber
- CB93153225
- Molecular Formula
- C43H66N6O8
- Formula Weight
- 795.02
- MOL File
- 1872382-47-2.mol
UNC3866 Property
- Boiling point:
- 1034.5±65.0 °C(Predicted)
- Density
- 1.129±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO
- form
- A crystalline solid
- pka
- 13.39±0.46(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19237
- Product name
- UNC3866
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 19237
- Product name
- UNC3866
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 19237
- Product name
- UNC3866
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $278
- Updated
- 2024/03/01
- Product number
- 19237
- Product name
- UNC3866
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $578
- Updated
- 2024/03/01
- Product number
- D462375
- Product name
- N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serineMethylEster
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
UNC3866 Chemical Properties,Usage,Production
Description
UNC3866 is an inhibitor of chromobox homolog 7 (CBX7; Kd = 97 nM). It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 μM). UNC3866 pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 μM.
Uses
Polycomb group proteins (CBX4, CBX7) regulate cell fate decisions during embryogenesis. N-?[4-?(1,?1-Dimethylethyl)?benzoyl]?-?L-?phenylalanyl-?L-?alanyl-?L-?leucyl-?N6,?N6-?diethyl-?L-?lysyl-?L-serine Methyl Ester is a selective antagonist of CBX4 and CBX7 chromodomains. It also inhibits prostate cell proliferation.
UNC3866 Preparation Products And Raw materials
Raw materials
Preparation Products
UNC3866 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from UNC3866 manufacturers
- Product
- UNC3866 1872382-47-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-13