Azido-PEG3-Maleimide
- Product Name
- Azido-PEG3-Maleimide
- CAS No.
- 1858264-36-4
- Chemical Name
- Azido-PEG3-Maleimide
- Synonyms
- N3-PEG3-Mal;Azido-PEG4-BMPA;Azide-PEG3-maleimide;Azido-PEG3-Maleimide;1H-Pyrrole-1-propanamide, N-[2-[2-[2-(2-azidoethoxy) ethoxy] ethoxy] ethyl]-2,5-dihydro-2,5-dioxo-
- CBNumber
- CB93162867
- Molecular Formula
- C15H23N5O6
- Formula Weight
- 369.37302
- MOL File
- 1858264-36-4.mol
N-Bromosuccinimide Price
- Product number
- 35111
- Product name
- Azido-PEG3-maleimide
- Packaging
- 5MG
- Price
- $67.2
- Updated
- 2021/12/16
- Product number
- BP-22468
- Product name
- Azido-PEG3-Maleimide
- Purity
- 95%
- Packaging
- 25mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 35111
- Product name
- Azido-PEG3-maleimide
- Packaging
- 25MG
- Price
- $123.2
- Updated
- 2021/12/16
- Product number
- CS-0114354
- Product name
- Azido-PEG3-maleimide
- Packaging
- 25mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- BP-22468
- Product name
- Azido-PEG3-Maleimide
- Purity
- 95%
- Packaging
- 100mg
- Price
- $195
- Updated
- 2021/12/16
Azido-PEG3-Maleimide Chemical Properties,Usage,Production
Description
Azido-PEG3-Maleimide is provided as a kit of two vials. Azido-PEG3-Maleimide is not stable for storage; it needs to be made in situ by mixing Azido-PEG3-amine and Maleimide-NHS ester followed by shaking/ stirring for 30 minutes at room temperature. The maleimide group of the Azido-PEG3-Maleimide can react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Azide group enables Click Chemsitry reactions.
Biological Activity
Azido-PEG3-maleimide is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules. Azido-PEG3-maleimide is also a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Cleavable
|