ChemicalBook > CAS DataBase List > 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

Product Name
5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
CAS No.
566-26-7
Chemical Name
5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
Synonyms
7alpha-Cholesterol;7α-Hydroxy Cholesterol;Cholest-5-En-3Β,7Α-Diol;Cholesterol Impurity 28;5-CHOLESTEN-3β, 7α-DIOL;7-ALPHA-HYDROXYCHOLESTEROL;7a-Hydroxycholest-5-en-3ol;7-alfa-Hydroxy-Cholesterol;3β,7α-Dihydroxycholest-5-ene;(3,7a)-Cholest-5-ene-3,7-diol
CBNumber
CB9321715
Molecular Formula
C27H46O2
Formula Weight
402.66
MOL File
566-26-7.mol
More
Less

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Property

Melting point:
168-170°C
Boiling point:
515.3±38.0 °C(Predicted)
Density 
1.03±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Soluble in DMSO or in Ethanol.
form 
solid
pka
14.11±0.70(Predicted)
color 
White or pale yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
H917990
Product name
7α-HydroxyCholesterol
Packaging
5mg
Price
$305
Updated
2021/12/16
IsoSciences
Product number
13410
Product name
7α-Hydroxycholesterol
Purity
≥98%
Packaging
1mg
Price
$195
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0005077
Product name
CHOLEST-5-EN-3-BETA-7-ALPHA-DIOL
Purity
95.00%
Packaging
5MG
Price
$497.13
Updated
2021/12/16
More
Less

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Chemical Properties,Usage,Production

Description

7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.??A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3?Possible biomarker for cellular lipid peroxidation.4

Chemical Properties

White Solid

Uses

Secondary metabolite of Cholesterol.

Definition

ChEBI: The 7alpha-hydroxy derivative of cholesterol.

References

[1] WILLIAM C. DUANE  Norman B J. Conversion of 7α-hydroxycholesterol to bile acid in human subjects: Is there an alternate pathway favoring cholic acid synthesis?[J]. Journal of Laboratory and Clinical Medicine, 2002, 139 2: Pages 109-115. DOI:10.1067/mlc.2002.121023
[2] SUN-MI KIM . 7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C–C motif) ligand 2[J]. Biochemical and biophysical research communications, 2015, 467 4: Pages 879-884. DOI:10.1016/j.bbrc.2015.10.050
[3] SUN-MI KIM . 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes[J]. Toxicology and applied pharmacology, 2014, 274 3: Pages 462-470. DOI:10.1016/j.taap.2013.12.007
[4] YOSHIRO SAITO  Noriko N. 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: Difference between cellular and plasma lipid peroxidation[J]. Biochemical and biophysical research communications, 2014, 446 3: Pages 741-744. DOI:10.1016/j.bbrc.2013.12.083

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Suppliers

Canada 1 China 79 India 4 United States 10 Global 94
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7471
Advantage
65
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29759
Advantage
68
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-028-85370565-229-229 18080489829
Email
18080489829@163.com
Country
China
ProdList
8250
Advantage
60
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15083
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9988
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
10063
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Aktin Chemicals, Inc.
Tel
028-85159085
Fax
86-28-85159085 Ex:604
Email
info@aktinchem.com
Country
CHINA
ProdList
1025
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
18108052721
Email
2850505130@qq.com
Country
China
ProdList
5167
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569266 +86-17392581500
Fax
029-88380327
Email
1015@dideu.com
Country
China
ProdList
3987
Advantage
58
Aktin Chemicals, Inc.
Tel
028-85159085
Email
info@aktinchem.com
Country
China
ProdList
1860
Advantage
58
Qingdao Tenglong microwave technology co., LTD.
Tel
0532-83818797 18561885118
Email
market@tlwb.com.cn
Country
China
ProdList
3944
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Jiangsu Wansipu Technology Co., Ltd.
Tel
17826022701
Email
1485609990@qq.com
Country
China
ProdList
999
Advantage
58
Manhag Testing Technology Co., Ltd
Tel
020-3846 2365 19110442770
Email
458677837@qq.com
Country
China
ProdList
7775
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
29668
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Yancheng Tongming Biotechnology Co., Ltd.
Tel
15195160625
Email
2863565288@qq.com
Country
China
ProdList
5192
Advantage
58
ChemeGen
Tel
18818260767
Fax
QQ 3610331285
Email
2625930290@qq.com
Country
China
ProdList
6973
Advantage
58
Shanghai Taopu Industrial Co., LTD
Tel
159-00573766 18018507602
Email
394643792@qq.com
Country
China
ProdList
4328
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175-877 18933936954
Email
tianwen.zhan@cato-chem.com
Country
China
ProdList
7259
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29784
Advantage
58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
18003
Advantage
58
Hubei DAHAO Chemical Co., Ltd.
Tel
027-027-59106191 13986034860
Email
1400828855@qq.com
Country
China
ProdList
8919
Advantage
58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel
024-024-024-88590548 18341751992
Email
757984502@qq.com
Country
China
ProdList
942
Advantage
58
Shanghai isotope chemical co.,ltd
Tel
021-51600108 13062666369
Email
sales@isotopechem.com
Country
China
ProdList
5000
Advantage
58
Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 086-15871494362 13720134139
Email
orders@jknbiochem.com
Country
China
ProdList
6762
Advantage
58
Hubei Chenghai Chemical Co., Ltd
Tel
027-59220433 18327245847
Email
1400838877@qq.com
Country
China
ProdList
9875
Advantage
58
Shanghai Beiwanta Biotechnology Co., Ltd.
Tel
021-67187366 19901745723
Email
info@bwtlab.com
Country
China
ProdList
9651
Advantage
58
Shandong Mopai Biotechnology Co., Ltd
Tel
13053322091
Email
admin@mopaikeji.com
Country
China
ProdList
5830
Advantage
58
Baoji Didu Pharmaceutical and Chemical Co., Ltd
Tel
029-81145305 17791533577
Email
1021@dideu.com
Country
China
ProdList
10009
Advantage
58
Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd
Tel
020-18102736 18102736234
Email
LK@zlstandards.com
Country
China
ProdList
8206
Advantage
58
Wuhan Huangzhen Biochemical Co., Ltd
Tel
13795480948
Email
3450865996@qq.com
Country
China
ProdList
4958
Advantage
58
Hubei CuiRan Biotechnology Co., Ltd.
Tel
00-1816279-5156 18162795156
Email
3391961471@qq.com
Country
China
ProdList
4332
Advantage
58

566-26-7, 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOLRelated Search:

beta-Sitosterol Hydroxyecdysone MOSLOFLAVONE alpha-Cyperone alpha-Terpineol hydroxygenkwanin 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one Artemether beta-Eudesmol 7BETA-HYDROXYCHOLESTEROL Fluvastatin sodium salt 25-HYDROXYCHOLESTEROL U 18666A 24(S),25-Epoxycholesterol (not deuterated) 7-KETOCHOLESTEROL CHOLESTENONE(RG) 1-CYCLOHEXYL-2-BUTEN-1-OL

  • 7-ALPHA-HYDROXYCHOLESTEROL
  • 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
  • cholest-5-en-3 beta,7 alpha-diol
  • (3,7a)-Cholest-5-ene-3,7-diol
  • 7a-Hydroxycholest-5-en-3ol
  • 3β,7α-Dihydroxycholest-5-ene
  • 7alpha-Cholesterol
  • Cholest-5-ene-3,7-diol, (3beta,7alpha)-
  • Cholest-5-ene-3,7-diol, (3b,7a)-
  • 7-alfa-Hydroxy-Cholesterol
  • 7α-Hydroxycholesterol (Solution)
  • Cholest-5-ene-3,7-diol, (3β,7α)-
  • 7α-Hydroxy Cholesterol
  • Cholest-5-En-3Β,7Α-Diol
  • Cholesterol Impurity 28
  • (3beta,7alpha)-cholest-5-ene-3,7-diol
  • peroxidation,Cholesterol,7α-Hydroxycholesterol,non-enzymatic,oxide,inhibit,biomarker,enzymatic,lipid,oxidation,Inhibitor,7α Hydroxycholesterol,7αHydroxycholesterol
  • 5-CHOLESTEN-3β, 7α-DIOL
  • 7alpha-Hydroxycholesterol, Bile acid precursor
  • 7α-Hydroxycholesterol, 10 mM in DMSO
  • 566-26-7
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids