5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Property

Melting point:

168-170°C

Boiling point:

515.3±38.0 °C(Predicted)

Density 

1.03±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Soluble in DMSO or in Ethanol.

form 

solid

pka

14.11±0.70(Predicted)

color 

White or pale yellow

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Hazard and Precautionary Statements (GHS)

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Chemical Properties,Usage,Production

Description

7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.??A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3?Possible biomarker for cellular lipid peroxidation.4

Chemical Properties

White Solid

Uses

Secondary metabolite of Cholesterol.

Definition

ChEBI: The 7alpha-hydroxy derivative of cholesterol.

References

1) Duane and Javitt (2002),?Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med.,?139?109 2) Kim?et al.?(2015)?7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun.,?467?879 3) Kim?et al.?(2014)?27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol.,?274?462 4) Saito and Noguchi (2014)?7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun.,?446?741