2'-O-Methylcytidine

Product Name: 2'-O-Methylcytidine
CAS No.: 2140-72-9
Chemical Name: 2'-O-Methylcytidine
Synonyms: 4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one;OMe-rC;2'-OMe-C;2'-OMe-rC;2'-OMe-Cr;2'-O-Me-dC;2'-O-Me-rC;2'-OMe Cytidine;2'-OMe-cytidine;2'-Methoxycytidine
CBNumber: CB9324099
Molecular Formula: C10H15N3O5
Formula Weight: 257.24
MOL File: 2140-72-9.mol

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2'-O-Methylcytidine Property

Melting point:: 252-253 C
Boiling point:: 506.0±60.0 °C(Predicted)
Density: 1.68±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO.
pka: 13.37±0.70(Predicted)
form: Powder
color: White to Off-white
PH: 4.2
optical activity: 70.902° (C=0.01 g/ml, H2O)
λmax: 281 (pH 1)；273 (EtOH)
InChI: InChI=1S/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1
InChIKey: RFCQJGFZUQFYRF-ZOQUXTDFSA-N
SMILES: OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OC)[C@@H]1O
CAS DataBase Reference: 2140-72-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2317
Product name: 2'-O-Methylcytidine
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: M2317
Product name: 2'-O-Methylcytidine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $185
Updated: 2025/07/31

Usbiological

Product number: 296261
Product name: 2'-O-Methylcytidine
Packaging: 300mg
Price: $333
Updated: 2021/12/16

TRC

Product number: M294660
Product name: 2’-O-MethylCytidine
Packaging: 5g
Price: $480
Updated: 2021/12/16

Matrix Scientific

Product number: 092960
Product name: 2'-O-Methylcytidine
Purity: 98%
Packaging: 1g
Price: $35
Updated: 2021/12/16

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2'-O-Methylcytidine Chemical Properties,Usage,Production

Description

2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon, making it an effective viral replication inhibitor. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways and may be able to bind to the response element on DNA, which could inhibit protein synthesis in cancer cells. It is an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50 = 3.8 μM). It inhibits HCV replication in a replicon assay (IC50 = 21.2 μM).

Chemical Properties

White powder

Uses

2'-O-Methylcytidine is used in the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Uses

Cytidine analog.

Definition

ChEBI: 2'-O-methylcytidine is a methylcytidine.

References

[1] GIOVANNI MIGLIACCIO. Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.[J]. The Journal of Biological Chemistry, 2003, 278 49: 49164-49170. DOI: 10.1074/jbc.m305041200

2'-O-Methylcytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-Methylcytidine Suppliers

Americas 1 Canada 2 China 241 Europe 1 Germany 2 India 7 Japan 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 5 United States 26 Global 289

Jiangsu Synthgene Biotechnology Co.,Ltd.

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TCI (Shanghai) Development Co., Ltd.

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Capot Chemical Co., Ltd

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View Lastest Price from 2'-O-Methylcytidine manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 2'-O-Methylcytidine 2140-72-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%MIN
Supply Ability: 20tons
Release date: 2025-08-26

Yunbio Tech Co.,Ltd.

Product: 2'-O-Methylcytidine 2140-72-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 300KG per month
Release date: 2023-03-04

Henan Fengda Chemical Co., Ltd

Product: 2'-O-Methylcytidine 2140-72-9
Price: US $6.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

2140-72-9, 2'-O-MethylcytidineRelated Search:

(Trifluoromethoxy)benzene Anisole Methoxyacetic acid 4-Methoxybenzoic acid p-Anisidine p-Anisaldehyde Methoxydiethylborane POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE 2'-O-Methyl-N4-Benzoyl-5'-O-DMT-Cytidine (R)-(-)-TETRAHYDROFURFURYL ALCOHOL (S)-(+)-1-DIMETHYLAMINO-2-PROPANOL 3-Methylcytidine 2''-METHYLCYTIDINE,2'-C-METHYLCYTIDINE 2''-DEOXY-5-METHYLCYTIDINE (5-METHYL-2''-DEOXYCYTIDINE),2'-DEOXY-5-METHYLCYTIDINE N4-BENZOYL-2'-O-METHYLCYTIDINE 2'-O-Methyl-N4-Acetyl-5'-O-DMT-Cytidine 5-Methylcytidine N4-Acetyl-2'-O-Methyl-cytidine

2'-OMe-C

4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidin-2-one

4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one

4-azanyl-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidin-2-one

2'-OMe Cytidine

4-aMino-1-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-1,2-dihydropyriMidin-2-one

2'-O-Methylcytidine, >98.0%(HPLC)

2'-O-Methylcytidine, >=99%

2''-(O-METHYL)-CYTIDINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM

4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one

2'-O-Methylcytidineanhydrous

2'-O-Methyl-D-cytidine

2'-O-Methylcytidine&gt

2'-OMe-rC

2'-O-Methylcytidine USP/EP/BP

4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-1,2-dihydropyrimidin-2-one

2'-OMe-Cr

2’-O-Methyl cytidine, RNA nucleoside Cm

OMe-rC

2'-O-Methylcytidine

2'-OMe-cytidine

2'-O-Me-dC

2'-O-Me-rC

Cytidine, 2'-O-methyl-

2'-O-Methyl-d3 Cytidine

2'-Methoxycytidine

2′-0-Methylcytidine

2'-O-Methylcytidine

2′-O-Methylcytidine - [M84857]

2140-72-9

Nucleosides, Nucleotides, Oligonucleotides

Nucleoside Analogs

BioChemical

Biochemicals and Reagents

Bases & Related Reagents

Carbohydrates & Derivatives

Heterocycles

Nucleotides

Nucleosides, Nucleotides, Oligonucleotides

Biochemicals and Reagents

Nucleoside Analogs

Nucleosides

Modified（deoxy）nucleoside

Nucleosides-2'-OMe Nucleosides