Tos-PEG4-acid
- Product Name
- Tos-PEG4-acid
- CAS No.
- 1453117-42-4
- Chemical Name
- Tos-PEG4-acid
- Synonyms
- Tos-PEG4-acid;3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoic acid;3-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]propanoic acid;Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-
- CBNumber
- CB93364036
- Molecular Formula
- C16H24O8S
- Formula Weight
- 376.42
- MOL File
- 1453117-42-4.mol
Tos-PEG4-acid Property
- Boiling point:
- 548.3±50.0 °C(Predicted)
- Density
- 1.256±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- pka
- 4.27±0.10(Predicted)
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-22937
- Product name
- Tos-PEG4-acid
- Purity
- 98%
- Packaging
- 100mg
- Price
- $280
- Updated
- 2021/12/16
Tos-PEG4-acid Chemical Properties,Usage,Production
Description
Tos-PEG4-acid is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
Tos-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6
Tos-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Tos-PEG4-acid Suppliers
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View Lastest Price from Tos-PEG4-acid manufacturers
- Product
- Tos-PEG4-acid 1453117-42-4
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >97.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-27