Tos-PEG4-acid

Product Name: Tos-PEG4-acid
CAS No.: 1453117-42-4
Chemical Name: Tos-PEG4-acid
Synonyms: Tos-PEG4-acid;3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoic acid;3-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]propanoic acid;Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-
CBNumber: CB93364036
Molecular Formula: C16H24O8S
Formula Weight: 376.42
MOL File: 1453117-42-4.mol

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Tos-PEG4-acid Property

Boiling point:: 548.3±50.0 °C(Predicted)
Density: 1.256±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
form: Liquid
pka: 4.27±0.10(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22937
Product name: Tos-PEG4-acid
Purity: 98%
Packaging: 100mg
Price: $280
Updated: 2021/12/16

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Tos-PEG4-acid Chemical Properties,Usage,Production

Description

Tos-PEG4-acid is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Tos-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6

Tos-PEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Tos-PEG4-acid Suppliers

China 25 United States 3 Global 28

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
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Jinan elephant international trading co., LTD

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Shanghai Yihe Biological Technology Co., Ltd.

Tel: 021-68882955 17721395025
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Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

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Block Chemical Technology (Shanghai) Co., LTD

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Zhengzhou Convergence Chemical Co. LTD

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Zhengzhou Akem Chemical Co., Ltd

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Beijing Jin Ming Biotechnology Co., Ltd.

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Email: psaitong@jm-bio.com
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View Lastest Price from Tos-PEG4-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Tos-PEG4-acid 1453117-42-4
Price: US $0.00/mg
Min. Order: 500mg
Purity: >97.00%
Supply Ability: 500mg
Release date: 2024-03-27

1453117-42-4, Tos-PEG4-acidRelated Search:

Tos-PEG5 t-butyl ester Tos-PEG2-CH2CO2tBu Tos-PEG2-t-butyl ester Tos-PEG4-CH2CO2H Tos-PEG4-t-butyl ester Tos-PEG6-t-Butyl ester Tos-PEG3-CH2CO2tBu Tos-PEG5-CH2CO2H Tos-PEG5-CH2CO2t-butyl ester Tos-PEG3-CH2CO2H

Tos-PEG4-acid

Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-

3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoic acid

3-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]propanoic acid

1453117-42-4

C16H24O8S