ChemicalBook > CAS DataBase List > Cysteamine hydrochloride

Cysteamine hydrochloride

Product Name
Cysteamine hydrochloride
CAS No.
156-57-0
Chemical Name
Cysteamine hydrochloride
Synonyms
CYSTEAMINE HCL;2-AMINOETHANETHIOL HYDROCHLORIDE;2-MERCAPTOETHYLAMINE HYDROCHLORIDE;Mercaptamine hydrochloride;mercaptoethylammonium chloride;2-Mercaptoethylammonium chloride;2-AMINOETHANE-1-THIOL HYDROCHLORIDE;2-AMINOETHANETHIOL HCL;Aminoethanethiol hydrochloride;DECARBOXYCYSTEINE HYDROCHLORIDE
CBNumber
CB9337215
Molecular Formula
C2H8ClNS
Formula Weight
113.61
MOL File
156-57-0.mol
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Cysteamine hydrochloride Property

Melting point:
67-71 °C
Boiling point:
238.5℃[at 101 325 Pa]
Density 
0.75
vapor pressure 
5.333Pa at 25℃
refractive index 
1.6100 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 1 m at 20 °C, clear, colorless
form 
Crystalline Powder or Pellets
color 
White
PH
3.3-5.0 (400g/l, H2O, 20℃)
Water Solubility 
VERY SOLUBLE
Sensitive 
Hygroscopic
λmax
λ: 280 nm Amax: ≤0.3
Merck 
14,2779
BRN 
3590083
Stability:
Stable, but hygroscopic. Incompatible with strong oxidizing agents.
InChIKey
OGMADIBCHLQMIP-UHFFFAOYSA-N
LogP
-2.14 at 25℃
CAS DataBase Reference
156-57-0(CAS DataBase Reference)
EPA Substance Registry System
Cysteamine hydrochloride (156-57-0)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36/37/39-26-36
RIDADR 
UN 3335
WGK Germany 
3
RTECS 
KJ0200000
F 
1-3-10-13
TSCA 
Yes
HS Code 
29309070
Toxicity
LD50 orally in Rabbit: 642 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.02835
Product name
Cysteaminium chloride
Purity
for synthesis
Packaging
10g
Price
$44.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.02835
Product name
Cysteaminium chloride
Purity
for synthesis
Packaging
25g
Price
$55.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.02835
Product name
Cysteaminium chloride
Purity
for synthesis
Packaging
100g
Price
$148
Updated
2024/03/01
Sigma-Aldrich
Product number
30078
Product name
Cysteamine hydrochloride
Purity
BioXtra
Packaging
25g
Price
$139
Updated
2024/03/01
TCI Chemical
Product number
A0296
Product name
2-Aminoethanethiol Hydrochloride
Purity
>95.0%(T)
Packaging
25g
Price
$40
Updated
2024/03/01
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Cysteamine hydrochloride Chemical Properties,Usage,Production

Description

Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.

Chemical Properties

White Solid

Uses

An inhibitor of DMBA-induced mammary tumors2-Mercaptoethylamine hydrochloride acts as a precursor in taurine biosynthesis and component of coenzyme A. It is involved in the preparation of active pharmaceutical ingredients like ranitidine and nizatidine. It acts as an antidote for acetaminophen poisoning. Further, it is used in the oral treatment of nephropathic cystinosis, radiation sickness and disorders of cysteine excretion. In addition to this, it serves as an antioxidant and an inhibitor of 7,12-Dimethylbenz[a]anthracene (DMBA)-induced tumors.

Uses

Cysteamine hydrochloride has been used in the in-situ generation of chiral cysteamine-capped cadmium sulfide quantum dots (CA-CdS QDs) for the sensing of Cd2+ and S2-.

Uses

Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.

General Description

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.

Hazard

Toxic by inhalation and ingestion.

Biochem/physiol Actions

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine. Cysteamine is used in a wide range of applications from regulation of gene expression, to depletion of somatostatin, to coating of nanoparticles.

Synthesis

In particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride.

Purification Methods

Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.]

Cysteamine hydrochloride Preparation Products And Raw materials

Raw materials

Monoethanolamine Carbon disulfide Hydrochloric acid Sulfuric acid

Preparation Products

THIAZOLIDINE 1,3-THIAZOLIDIN-2-ONE 2-AMINOETHYLMETHYLSULFONE HYDROCHLORIDE
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Cysteamine hydrochloride Suppliers

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View Lastest Price from Cysteamine hydrochloride manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Cysteamine hydrochloride 156-57-0
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
500Ton
Release date
2024-08-13
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Sodium Glycinate 6000-44-8
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-17
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Cysteamine hcl 156-57-0
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-17

156-57-0, Cysteamine hydrochlorideRelated Search:

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