Cysteamine hydrochloride

Product Name: Cysteamine hydrochloride
CAS No.: 156-57-0
Chemical Name: Cysteamine hydrochloride
Synonyms: CYSTEAMINE HCL;2-AMINOETHANETHIOL HYDROCHLORIDE;2-MERCAPTOETHYLAMINE HYDROCHLORIDE;Mercaptamine hydrochloride;mercaptoethylammonium chloride;2-Mercaptoethylammonium chloride;2-AMINOETHANE-1-THIOL HYDROCHLORIDE;2-AMINOETHANETHIOL HCL;Aminoethanethiol hydrochloride;DECARBOXYCYSTEINE HYDROCHLORIDE
CBNumber: CB9337215
Molecular Formula: C2H8ClNS
Formula Weight: 113.61
MOL File: 156-57-0.mol

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Cysteamine hydrochloride Property

Melting point:: 67-71 °C
Boiling point:: 238.5℃[at 101 325 Pa]
Density: 0.75
vapor pressure: 5.333Pa at 25℃
refractive index: 1.6100 (estimate)
storage temp.: 2-8°C
solubility: H₂O: 1 m at 20 °C, clear, colorless
form: Crystalline Powder or Pellets
color: White
PH: 3.3-5.0 (400g/l, H2O, 20℃)
Water Solubility: VERY SOLUBLE
Sensitive: Hygroscopic
λmax: λ: 280 nm Amax: ≤0.3
Merck: 14,2779
BRN: 3590083
Stability:: Stable, but hygroscopic. Incompatible with strong oxidizing agents.
InChIKey: OGMADIBCHLQMIP-UHFFFAOYSA-N
LogP: -2.14 at 25℃
CAS DataBase Reference: 156-57-0(CAS DataBase Reference)
EPA Substance Registry System: Cysteamine hydrochloride (156-57-0)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 36/37/39-26-36
RIDADR: UN 3335
WGK Germany: 3
RTECS: KJ0200000
F: 1-3-10-13
TSCA: Yes
HS Code: 29309070
Toxicity: LD50 orally in Rabbit: 642 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.02835
Product name: Cysteaminium chloride
Purity: for synthesis
Packaging: 10g
Price: $44.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.02835
Product name: Cysteaminium chloride
Purity: for synthesis
Packaging: 25g
Price: $55.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.02835
Product name: Cysteaminium chloride
Purity: for synthesis
Packaging: 100g
Price: $148
Updated: 2024/03/01

Sigma-Aldrich

Product number: 30078
Product name: Cysteamine hydrochloride
Purity: BioXtra
Packaging: 25g
Price: $139
Updated: 2024/03/01

TCI Chemical

Product number: A0296
Product name: 2-Aminoethanethiol Hydrochloride
Purity: >95.0%(T)
Packaging: 25g
Price: $40
Updated: 2024/03/01

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Cysteamine hydrochloride Chemical Properties,Usage,Production

Description

Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.

Chemical Properties

White Solid

Uses

An inhibitor of DMBA-induced mammary tumors2-Mercaptoethylamine hydrochloride acts as a precursor in taurine biosynthesis and component of coenzyme A. It is involved in the preparation of active pharmaceutical ingredients like ranitidine and nizatidine. It acts as an antidote for acetaminophen poisoning. Further, it is used in the oral treatment of nephropathic cystinosis, radiation sickness and disorders of cysteine excretion. In addition to this, it serves as an antioxidant and an inhibitor of 7,12-Dimethylbenz[a]anthracene (DMBA)-induced tumors.

Uses

Cysteamine hydrochloride has been used in the in-situ generation of chiral cysteamine-capped cadmium sulfide quantum dots (CA-CdS QDs) for the sensing of Cd²⁺ and S^2-.

Uses

Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.

General Description

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.

Hazard

Toxic by inhalation and ingestion.

Biochem/physiol Actions

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine. Cysteamine is used in a wide range of applications from regulation of gene expression, to depletion of somatostatin, to coating of nanoparticles.

Synthesis

In particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride.

Purification Methods

Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.]

Cysteamine hydrochloride Preparation Products And Raw materials

Raw materials

Monoethanolamine Carbon disulfide Hydrochloric acid Sulfuric acid

Preparation Products

THIAZOLIDINE 1,3-THIAZOLIDIN-2-ONE 2-AMINOETHYLMETHYLSULFONE HYDROCHLORIDE

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View Lastest Price from Cysteamine hydrochloride manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Cysteamine hydrochloride 156-57-0
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 500Ton
Release date: 2024-08-13

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Sodium Glycinate 6000-44-8
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-17

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Cysteamine hcl 156-57-0
Price: US $180.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-17

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