AZD0364

Product Name: AZD0364
CAS No.: 2097416-76-5
Chemical Name: AZD0364
Synonyms: CS-2696;AZD0364;ADZ0346;Tizaterkib;ERK2 inhibitor;AZD0364 (ATG-017);AZD-0364/Tizaterkib;AZD 0364;AZD0364;ERK2 INHIBITOR;inhibit,ERK,AZD0364,AZD 0364,Tizaterkib,Inhibitor,Extracellular signal regulated kinases;(R)-7-(3,4-Difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one
CBNumber: CB93379847
Molecular Formula: C24H24F2N8O2
Formula Weight: 494.5
MOL File: 2097416-76-5.mol

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AZD0364 Property

Boiling point:: 716.0±70.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:41.67(Max Conc. mg/mL);84.27(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);50.56(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.01(Max Conc. mM)
Ethanol:54.5(Max Conc. mg/mL);110.21(Max Conc. mM)
form: A crystalline solid
pka: 2?+-.0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29827
Product name: AZD 0364
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 29827
Product name: AZD 0364
Packaging: 10mg
Price: $672
Updated: 2024/03/01

Cayman Chemical

Product number: 29827
Product name: AZD 0364
Packaging: 5mg
Price: $410
Updated: 2024/03/01

ChemScene

Product number: CS-0042190
Product name: AZD-0364
Purity: 99.75%
Packaging: 10mg
Price: $480
Updated: 2021/12/16

Apolloscientific

Product number: BISN0049
Product name: AZD0364
Purity: 98%
Packaging: 10mg
Price: $617
Updated: 2021/12/16

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AZD0364 Chemical Properties,Usage,Production

Biological Activity

AZD0364 (ATG-017) is an ERK1/2 inhibitor with IC50 of 0.6 nM for ERK2.

in vitro

AZD0364 has high cellular activity against direct downstream substrates of the MAPK signaling pathway (as in BRAF.

in vivo

AZD0364 has good oral pharmacokinetics in various species. In a xenograft model, AZD0364 inhibited phosphorylated p90RSK1 in a concentration-dependent manner in tumors. AZD0634 induces tumor regression in a KRAS-mutated NSCLC Calu 6 xenograft model, in which AZD0634 can be safely and effectively administered in combination with selumetinib.

target

Target	Value
ERK2 ()	0.6 nM

AZD0364 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD0364 Suppliers

China 50 India 1 United States 7 Global 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52925
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

2097416-76-5, AZD0364Related Search:

AZD-5672 CCR1 antagonist AZD-7648 AZD5153 AZD-8055 AZD-0284 AZD-5305 AZD 3759 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- AZD3839 hemifuMarate KGZHRAVDXGQUQM-WCQGTBRESA-N (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD-2858 AZD-0156

AZD0364

CS-2696

AZD 0364;AZD0364;ERK2 INHIBITOR

ERK2 inhibitor

ADZ0346

Imidazo[1,2-a]pyrazin-8(5H)-one, 7-[(3,4-difluorophenyl)methyl]-6,7-dihydro-6-(methoxymethyl)-2-[5-methyl-2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-, (6R)-

Tizaterkib

AZD-0364/Tizaterkib

AZD0364 (ATG-017)

inhibit,ERK,AZD0364,AZD 0364,Tizaterkib,Inhibitor,Extracellular signal regulated kinases

(R)-7-(3,4-Difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one

2097416-76-5

C24H24F2N8O2

API