ChemicalBook > CAS DataBase List > Meclizine dihydrochloride

Meclizine dihydrochloride

Product Name
Meclizine dihydrochloride
CAS No.
1104-22-9
Chemical Name
Meclizine dihydrochloride
Synonyms
diadril;bonamine;NSC 28728;Navidoxine;Meclozine Hcl;)-4-(3-methyL;Meclizine 2HCl;Meclizine diHCl;Meclozine ,Bonamine;ancolandihydrochloride
CBNumber
CB9362486
Molecular Formula
C25H29Cl3N2
Formula Weight
463.87
MOL File
1104-22-9.mol
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Meclizine dihydrochloride Property

Melting point:
210.0 to 214.0 °C
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
color 
white to beige
CAS DataBase Reference
1104-22-9(CAS DataBase Reference)
EPA Substance Registry System
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (1104-22-9)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-63
Safety Statements 
22-36
WGK Germany 
3
RTECS 
TL2005000
HS Code 
2933.59.8000
Toxicity
LD50 oral in mouse: 1600mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0950
Product name
Meclizine dihydrochloride
Purity
≥97% (HPLC)
Packaging
50mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
M0220000
Product name
Meclozine dihydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
m0220000
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
BP220
Product name
Meclozine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$266
Updated
2024/03/01
TCI Chemical
Product number
M2755
Product name
Meclizine Dihydrochloride
Purity
>98.0%(HPLC)
Packaging
5g
Price
$71
Updated
2024/03/01
TCI Chemical
Product number
M2755
Product name
Meclizine Dihydrochloride
Purity
>98.0%(HPLC)
Packaging
25g
Price
$210
Updated
2023/06/20
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Meclizine dihydrochloride Chemical Properties,Usage,Production

Description

Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.

Chemical Properties

White or yellowish-white, slightly hygroscopic, crystalline powder.

Originator

Antivert,Roerig,US,1957

Uses

Meclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.

Uses

Antiemetic;Histamine antagonist

Uses

cholinergic, diagnostic aid

Manufacturing Process

32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.

brand name

Antivert (Pfizer).

Therapeutic Function

Antinauseant

Biochem/physiol Actions

Meclizine has the ability to increase glycolysis and decrease cellular ATP levels in media that has glucose and galactose. It guards the kidney against ischemia-reperfusion injury. Meclizine is considered as an anti-nausea and anti-dizziness drug, was identified in a ′nutrient-sensitized′ chemical screen. In human, it acts as an agonist of pregnane X receptor (PXR). It enhances the expression of CYP3A4 (cytochrome P450 3A4) mRNA and reduces CYP3A-catalyzed testosterone 6β-hydroxylation in primary cultures of human hepatocytes.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.

Solubility in organics

Meclizine dihydrochloride is readily soluble in chloroform and pyridine, slightly soluble in dilute acids and ethanol, and insoluble in water or ether.

storage

Desiccate at RT

Meclizine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Meclizine dihydrochloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Meclizine dihydrochloride 1104-22-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Meclizine dihydrochloride 1104-22-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Meclizine dihydrochloride 1104-22-9
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-16

1104-22-9, Meclizine dihydrochlorideRelated Search:

Methyl salicylate Diphenhydramine Hydrochloride Cetirizine dihydrochloride Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride Piperacillin METSULFURON METHYL Kresoxim-methyl Piperazine 1-AdaMantanethylaMine Thiophanate-methyl 2-Methylbenzotrifluoride Meclozine Tribenuron methyl 1-Methylpiperazine Promethazine hydrochloride Methyl acetate Chlorpromazine hydrochloride Chlorodimethylphenylsilane

  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride
  • Meclozine Hcl
  • 1-((4-Chlorophenyl)(phenyl)Methyl)-4-(3-Methylbenzyl)piperazine dihydrochloride
  • Meclizine 2HCl
  • Piperazine,1-[(4-chlorophenyl)phenylMethyl]-4-[(3-Methylphenyl)Methyl]-, hydrochloride(1:2)
  • 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazine,hydrochloride (1:2)
  • 1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-piperazine dihydrochloride
  • 1-p-chlorbenzhydryl-m-methylbenzylpiperazinedihydrochloride
  • ancolandihydrochloride
  • bonamine
  • diadril
  • MECLIZINE DIHYDROCHLORIDE
  • 1-([4-CHLOROPHENYL]PHENYLMETHYL)-4-([3-METHYLPHENYL]-METHYL)PIPERAZINE DIHYDROCHLORIDE
  • 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-piperazindih
  • 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-piperazindihydrochlorid
  • 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazindihyd
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (9CI)
  • Postafene dihydrochloride
  • Piperazine, 1-(p-chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride
  • 1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)p
  • meclozinedihydrochloride
  • parachloraminedihydrochloride
  • Meclozine dihydrochloride monohydrate
  • Meclizine diHCl
  • 1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride
  • mecilizine hydrochloride
  • Navidoxine
  • NSC 28728
  • Piperazine, 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride (6CI, 8CI)
  • Meclozine ,Bonamine
  • MeclizineDihydrochloride&gt
  • Meclozine dihydrochloride CRS
  • )piperazine dihydrochL
  • )-4-(3-methyL
  • 1-(4-Chlorobenzhydryl)-4-(3-methylbenzyl)piperazine Dihydrochloride
  • Meclizine dihydrochloride USP/EP/BP
  • 1104-22-9
  • C25H27Cl2N22HCl
  • C25H27ClN22ClH
  • C25H29Cl3N2
  • C25H27ClN22HCl
  • PROVOCHOLINE