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2-METHYL-4-HYDROXYMETHYLPYRIDINE

Product Name
2-METHYL-4-HYDROXYMETHYLPYRIDINE
CAS No.
105250-16-6
Chemical Name
2-METHYL-4-HYDROXYMETHYLPYRIDINE
Synonyms
2-Methyl-4-pyridinemethanol;(2-Methyl-4-pyridyl)methanol;4-Pyridinemethanol, 2-methyl-;(2-Methylpyridin-4-yl)methanol;(2-methyl-4-pyridinyl)methanol;(2-Methylpyridine-4-yl)methanol;2-METHYL-4-HYDROXYMETHYLPYRIDINE;4-Pyridinemethanol,2-methyl-(9CI);4-(Hydroxymethyl)-2-methylpyridine;2-METHYL-4-HYDROXYMETHYLPYRIDINE ISO 9001：2015 REACH
CBNumber
CB9363544
Molecular Formula
C7H9NO
Formula Weight
123.15
MOL File
105250-16-6.mol
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2-METHYL-4-HYDROXYMETHYLPYRIDINE Property

Boiling point:
131-140 °C(Press: 4 Torr)
Density 
1.092±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
13.46±0.10(Predicted)
form 
powder
color 
Pale yellow
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L499730
Product name
2-Methyl-4-hydroxymethylpyridine
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$113
Updated
2025/07/31
Sigma-Aldrich
Product number
L499730
Product name
2-Methyl-4-hydroxymethylpyridine
Purity
Aldrich
Packaging
250mg
Price
$110
Updated
2024/03/01
TRC
Product number
M322180
Product name
(2-Methylpyridin-4-yl)methanol
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
M322180
Product name
(2-Methylpyridin-4-yl)methanol
Packaging
500mg
Price
$200
Updated
2021/12/16
Matrix Scientific
Product number
069912
Product name
2-Methyl-4-hydroxymethylpyridine
Purity
98%
Packaging
500mg
Price
$150
Updated
2021/12/16
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2-METHYL-4-HYDROXYMETHYLPYRIDINE Chemical Properties,Usage,Production

Synthesis Reference(s)

Synthesis, p. 483, 2002 DOI: 10.1055/s-2002-20960

Synthesis

152815-18-4

105250-16-6

General procedure for the synthesis of 2-methyl-4-hydroxymethylpyridine from (2-chloro-6-methylpyridin-4-yl)methanol: In a variant of the method described above, 2-chloro-6-methylpyridine-4-carboxylic acid, palladium catalyst (0.20 g, 10 mol% loaded on carbon), ethyl acetate (45 mL) and triethylamine (2.8 mL, 20 mmol) were mixed. The reaction mixture was placed under a hydrogen atmosphere at 1 atmosphere for 21 hours. Subsequently, additional Pearlman catalyst (0.2 g) was added and the reaction continued to be stirred for 5 hours under a hydrogen atmosphere to achieve dechlorination. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated. Purification by column chromatography (eluent ratio 5:95 methanol:dichloromethane) afforded (2-methylpyridin-4-yl)methanol (1.48 g, 88% yield). The obtained (2-methylpyridin-4-yl)methanol can be used to prepare 2-amino-3-(2-methylpyridin-4-yl)propionitrile, and 1-methyl-1H-indol-2-one carboxylic acid ((1S,2R)-2-{[cyano -(2-methylpyridin-4-ylmethyl)-methyl]-carbamoyl}-cyclohexyl)amide obtained by the method described above (186 mg, yield 62%). Results of mass spectrometry analysis: m/z 444 (M+H).

References

[1] Patent: US2004/77646, 2004, A1. Location in patent: Page 116

2-METHYL-4-HYDROXYMETHYLPYRIDINE Preparation Products And Raw materials

Raw materials

Nitrogen Ethanol 2,4-Lutidine Sodium chloride Sodium borohydride Diethylamine DIMETHYLFORMAMIDE HYDROGEN CHLORIDE COMPLEX Tetrahydrofuran Ammonium chloride Dichloromethane Methanol Sodium periodate Magnesium sulfate n-Butyllithium

Preparation Products

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2-METHYL-4-HYDROXYMETHYLPYRIDINE Suppliers

China 97 Europe 1 Germany 2 India 3 United Kingdom 2 United States 9 Global 114
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Matrix Scientific
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View Lastest Price from 2-METHYL-4-HYDROXYMETHYLPYRIDINE manufacturers

Dideu Industries Group Limited
Product
2-METHYL-4-HYDROXYMETHYLPYRIDINE 105250-16-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-27

105250-16-6, 2-METHYL-4-HYDROXYMETHYLPYRIDINERelated Search:

2,2'-BIQUINOLINE-4,4'-DICARBOXYLIC ACID DIPOTASSIUM SALT TRIHYDRATE 3-Hydroxy-2-methyl-4-quinolinecarboxylic acid 4-Pyridoxic acid Pyridoxine hydrochloride CINCHOPHEN Bicinchoninic Acid Disodium Salt 2,4-Pyridinedicarboxylic acid ETHYL 2-CHLORO-3-CYANO-6-METHYLISONICOTINATE 2,2'-Bipyridine-4,4'-dicarboxylic acid oxycinchophen Pyridoxine Pyrroloquinoline quinone 6-CHLORO-2-(4-CHLOROPHENYL)-4-QUINOLINE CARBOXYLIC ACID Dimethyl 2,4-pyridinedicarboxylate 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER 6-METHOXY-2-PHENYL-4-QUINOLINECARBOXYLIC ACID NEOCINCHOPHEN 2-(3-CARBOXY-4-HYDROXYPHENYL) QUINOLINE-4-CARBOXYLIC ACID

  • (2-methyl-4-pyridinyl)methanol
  • 2-METHYL-4-HYDROXYMETHYLPYRIDINE
  • 4-Pyridinemethanol,2-methyl-(9CI)
  • (2-Methylpyridin-4-yl)methanol
  • 4-(Hydroxymethyl)-2-methylpyridine
  • (2-Methylpyridin-4-yl)methanol, 4-(Hydroxymethyl)-2-picoline
  • (2-Methyl-4-pyridyl)methanol
  • 4-Pyridinemethanol, 2-methyl-
  • 2-METHYL-4-HYDROXYMETHYLPYRIDINE ISO 9001：2015 REACH
  • 2-Methyl-4-pyridinemethanol
  • (2-Methylpyridine-4-yl)methanol
  • 105250-16-6
  • PYRIDINE