ChemicalBook > CAS DataBase List > Amlodipine

Amlodipine

Product Name
Amlodipine
CAS No.
88150-42-9
Chemical Name
Amlodipine
Synonyms
AMLODIPINE BASE;besylate;Amlodipin;AmL;phytoxanthin;AMlodipine-d4 Maleate;Amlodipine base (crystalline);3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate;Isti;LOTREL
CBNumber
CB9366505
Molecular Formula
C20H25ClN2O5
Formula Weight
408.88
MOL File
88150-42-9.mol
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Amlodipine Property

Melting point:
178-179°C
Boiling point:
527.2±50.0 °C(Predicted)
Density 
1.227±0.06 g/cm3(Predicted)
RTECS 
US7968329
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka
pKa 8.6 (Uncertain)
form 
Almost white crystal powder
color 
White
Water Solubility 
75.3 mg/L
BCS Class
1
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference
88150-42-9(CAS DataBase Reference)
EPA Substance Registry System
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (88150-42-9)
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Safety

HazardClass 
IRRITANT
HazardClass 
6.1
Hazardous Substances Data
88150-42-9(Hazardous Substances Data)
Toxicity
TDLo orl-chd: 400 mg/kg:BPR AJEMEN 18,581,2000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J62242
Product name
Amlodipine, 97+%
Packaging
1g
Price
$110.65
Updated
2024/03/01
Alfa Aesar
Product number
J62242
Product name
Amlodipine, 97+%
Packaging
5g
Price
$420.65
Updated
2024/03/01
Cayman Chemical
Product number
14838
Product name
Amlodipine
Purity
≥98%
Packaging
1g
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
14838
Product name
Amlodipine
Purity
≥98%
Packaging
5g
Price
$401
Updated
2024/03/01
Alfa Aesar
Product number
J62242
Product name
Amlodipine, 97+%
Packaging
10g
Price
$601.65
Updated
2024/03/01
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Amlodipine Chemical Properties,Usage,Production

Description

Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle. Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo. Formulations containing amlodipine have been used in the treatment of hypertension.

Chemical Properties

Yellow Solid

Uses

anti-hypertensive;calcium channel blocker

Uses

A deuterated dihydropyridine calcium channel blocker.;Application of Labeled APIs: Labeled Amlodipine, intended for use as an internal standard for the quantification of Amlodipine by GC- or LC-mass spectrometry.

Uses

A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.

Definition

ChEBI: A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.

brand name

Norvasc (Pfizer).

General Description

Amlodipine, 2-[, for the treatment of hypertension. Amlodipineis also marketed as a combination therapy with atorvastatinunder the tradename Norvasc for the management of highcholesterol and high blood pressure.

Hazard

Human systemic effects.

Clinical Use

Calcium-channel blocker:
Hypertension
Angina prophylaxis

Safety Profile

Human systemic effects. Whenheated to decomposition it emits toxic vapors of NOx andCl-.

Drug interactions

Potentially hazardous interactions with other drugs
Aminophylline and theophylline: possibly increased aminophylline and theophylline concentration.
Anaesthetics: enhanced hypotensive effect.
Antibacterials: metabolism possibly inhibited by clarithromycin, erythromycin and telithromycin.
Antidepressants: enhanced hypotensive effect with MAOIs, concentration possibly reduced by St John’s wort.
Antiepileptics: effects probably reduced by phenobarbital and primidone.
Antifungals: negative inotropic effect possibly increased with itraconazole.
Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotensive effect of postsynaptic alpha-blockers.
Antivirals: concentration increased by telaprevir and possibly by ritonavir - reduce dose of amlodipine.
Ciclosporin: ciclosporin concentration may be increased by up to 40%.
Lipid lowering agents: possibly increased risk of myopathy - do not exceed 20 mg of simvastatin.1 Tacrolimus: possibly increased tacrolimus levels.

Metabolism

Amlodipine is extensively metabolised by the liver to inactive metabolites with 10% of the parent compound and 60% of metabolites excreted in the urine.

References

1) Mason et al. (2003), Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine; Arterioscler. Thromb. Vasc. Biol., 23 2155 2) Asano et al. (2003), A calcium channel blocker activates both ecto-5(‘)-nucleotidase and NO synthase in HUVEC; Biochem. Biophys. Res. Commun., 311 625 3) Yu et al. (2003), Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction; Hypertension, 42 329 4) Zhou et al. (2004), Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats; Am. J. Hypertension, 17 167 5) Ueda et al. (1993), A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects; Br. J. Clin. Pharmacol., 36 561

Amlodipine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Chloroacetyl Monoethanolamine Methyl 3-aminocrotonate Maleic acid PHENRAMINE MALEATE 2-Chlorobenzaldehyde

Preparation Products

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View Lastest Price from Amlodipine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Amlodipine 88150-42-9
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg/month
Release date
2021-11-26
Hebei Yanxi Chemical Co., Ltd.
Product
amlodipine 88150-42-9
Price
US $0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
500kg
Release date
2023-10-08
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Amlodipine 88150-42-9
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-01

88150-42-9, AmlodipineRelated Search:

Methyl acrylate Ethyl formate Chromium picolinate Kresoxim-methyl Paraquat dichloride Diethyl phthalate Acetonitrile Methylparaben Basic Violet 1 Urethane 2-Picolinic acid Methyl acetate Dihydromyrcenol Diethyl azodicarboxylate Triethyl orthoformate acetic acid, triethoxy-, ethyl ester Methanol Levetiracetam

  • 3,5-pyridinedicarboxylicacid,1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor
  • Amlodipine base (crystalline)
  • (R)-3-ethyl 5-methyl 2
  • 3-ethyl5-methylester
  • LOTREL
  • methyl ethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • AMLODIPINE
  • AMLODIPINE BASE
  • Amlodipin
  • besylate
  • AMLODIPINE MM(CRM STANDARD)
  • Amlodipine&Int
  • AmlodipineBesylate/Maleate
  • 3,5-Pyridinedicarboxylic acid, 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
  • ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Pelmec
  • Racemic Amlodipine
  • 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor 3-ethyl 5-methyl ester
  • 3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Amlodipine Besilate Imp.(EP)
  • 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-ethyl O5-methyl ester
  • Amlodipine besilate (JAN)
  • Amlodipine besylate (USAN)
  • Isti
  • O3-ethyl O5-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Amlodipine, >=99%
  • (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • 4-(2-chloro-phenyl-2(3-(1,3-dioxo-l,3-dihydro-isoindol-2yl-prpionyl)6-methyl-pyridin3, 5-dicarboxylic acid-ethyl-ethyl ester 5-methyl ester (p-2) of RS amlodipine besylate
  • AMlodipine besylate, >95%
  • Amlodipine Besylate IMP
  • phytoxanthin
  • Amlodipine (base and/or unspecified salts)
  • AMLODIPINE (BASE & SALTS)
  • Amlodipine ( Amlodipine Benzenesulfonate)
  • 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1，4-dihydro-3，5-pyridinedicarboxylic acid 5-methyl 3-ethyl ester
  • UK-48340
  • UK-48340-11
  • 2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl=5-methyl ester
  • 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
  • 2-Methyl-4-(2-chlorophenyl)-6-[[(2-aminoethyl)oxy]methyl]-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-ethyl ester
  • 4-(2-Chlorophenyl)-2-methyl-6-(2-aminoethoxymethyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-ethyl ester
  • 4-(2-Chlorophenyl)-6-methyl-2-(2-aminoethoxymethyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl ester
  • 3-ethyl 5-Methyl (4S)-2-[(2-aMinoethoxy)Methyl]-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • AMlodipine(Norvasc)
  • AMlodiping Besylate
  • (R,S)-AMlodipine
  • AMlopres
  • Intervask
  • 2-((2-Aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
  • AMLODIPINE (RS)-3-ETHYL-5-METHYL-2[(2-AMINOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
  • AMlodipine-d4 Maleate
  • [2H4]-Amlodipine besylate
  • AmL
  • odipine besyL
  • Amlodipine Solution in Methanol, 100μg/mL
  • Amlodipine USP/EP/BP
  • Amlodipine (UK-48340
  • amlodipineQ: What is amlodipine Q: What is the CAS Number of amlodipine Q: What is the storage condition of amlodipine Q: What are the applications of amlodipine