3-(4-METHYLBENZYLIDENE)CAMPHOR

Product Name: 3-(4-METHYLBENZYLIDENE)CAMPHOR
CAS No.: 36861-47-9
Chemical Name: 3-(4-METHYLBENZYLIDENE)CAMPHOR
Synonyms: 4-METHYLBENZYLIDENE CAMPHOR;Enzacamene;PARSOL 5000;3-(4-METHYLBENZYLIDINE)CAMPHOR;MBC 95;UV 4MBC;MEXORYLSD;NEO-HELIOPAN;Zinc01481820;EUSOLEX 6300
CBNumber: CB9366893
Molecular Formula: C18H22O
Formula Weight: 254.37
MOL File: 36861-47-9.mol

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3-(4-METHYLBENZYLIDENE)CAMPHOR Property

Melting point:: 66-68°C
Boiling point:: 198-200 °C
Density: 1.064±0.06 g/cm3(Predicted)
RTECS: DT5099565
storage temp.: Inert atmosphere,Room Temperature
solubility: insoluble in H2O; ≥10 mg/mL in DMSO; ≥111.2 mg/mL in EtOH
form: Solid
color: White to off-white
BRN: 9213949
LogP: 3.385 (est)
CAS DataBase Reference: 36861-47-9(CAS DataBase Reference)
EPA Substance Registry System: Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]- (36861-47-9)

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Safety

Hazard Codes: Xn
Risk Statements: 63
Safety Statements: 22-24/25-36/37
WGK Germany: 2
TSCA: Yes
HS Code: 2914399000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2805
Product name: Methyl Benzylidene Camphor
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 400MG
Price: $182
Updated: 2024/03/01

Sigma-Aldrich

Product number: 61547
Product name: 3-(4-Methylbenzylidene)camphor
Purity: certified reference material, TraceCERT
Packaging: 50mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1424222
Product name: Methyl benzylidene camphor
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 13840
Product name: 4-Methylbenzylidene camphor
Purity: ≥98%
Packaging: 1g
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 13840
Product name: 4-Methylbenzylidene camphor
Purity: ≥98%
Packaging: 5g
Price: $537
Updated: 2024/03/01

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3-(4-METHYLBENZYLIDENE)CAMPHOR Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

3-(4-Methylbenzyliden)camphor is an UV-B absorbing agent in sunscreen cosmetics of the type creams, lotions, lipsticks, sun oils, etc.

Uses

3-(4-Methylbenzylidene)camphor is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. 4-Methylbenzylidene camphor(4-MBC) a UV-B ray filter, is an endocrine disruptors (ED).

Uses

4-(Methylbenzylidene)camphor (4-MBC), a UV-B ray filter, is an endocrine disruptors (ED).

Biological Activity

4-methylbenzylidene camphor (4-mbc) is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.since the estrogen receptor (er) ligand type can influence transactivation, it is important to obtain information on molecular actions of nonclassical er agonists.

in vitro

previous results of competitive binding assays using cytosolic protein preparations from xenopus hepatocytes demonstrated that 4-mbc could weakly bind to the er. in addition, 4-mbc at a 100 micromol/l was not able to replace estradiol from the receptor completely [1].

in vivo

the estrogen target gene expression in uterus of long evans rats after exposure to 4-mbc was studied. results showed that 4-mbc could altere steady-state levels of mrnas encoding for er, progesterone receptor (pr), and androgen recepto in uterus of 12-wk-old offspring. to evaluate sensitivity to estradiol (e2), offspring were injected with e2, and killed 6 h later. acute up-regulation of pr and igf-i and down-regulation of er and androgen receptor by e2 were reduced in 4-mbc treated rats dose-dependently [2].

References

[1] klann a, levy g, lutz i, müller c, kloas w, hildebrandt jp. estrogen-like effects of ultraviolet screen 3-(4-methylbenzylidene)-camphor (eusolex 6300) on cell proliferation and gene induction in mammalian and amphibian cells. environ res. 2005 mar;97(3):274-81.
[2] s. durrer, k. maerkel, m. schlumpf, et al. estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor. endocrinology 146(5), 2130-2139 (2005).
[3] n. r. janjua, b. mogensen, a. m. andersson, et al. systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. journal of investigative dermatology 123, 57-61(2004).

3-(4-METHYLBENZYLIDENE)CAMPHOR Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-METHYLBENZYLIDENE)CAMPHOR Suppliers

Canada 1 China 206 France 2 Germany 4 India 1 United Kingdom 3 United States 18 Global 235

MedChemexpress LLC

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View Lastest Price from 3-(4-METHYLBENZYLIDENE)CAMPHOR manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 4-Methylbenzylidene Camphor 36861-47-9
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-14

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-(4'-Methylbenzylidene)camphor 36861-47-9
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 500kg
Release date: 2021-11-05

Hebei Weibang Biotechnology Co., Ltd

Product: 3-(4-METHYLBENZYLIDENE)CAMPHOR 36861-47-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

36861-47-9, 3-(4-METHYLBENZYLIDENE)CAMPHORRelated Search:

Trimethyl borate Heptane Dibenzylideneacetone Sodium 1-heptanesulfonate p-Toluic acid Benzyl bromide BENZYL GLYCIDYL ETHER N,N-Dimethylbenzylamine Camphor Benzyltriethylammonium chloride Benzyl chloride Benzyltrimethylammonium chloride Chalcone Toluene 2-BENZYLIDENECYCLOHEXANONE alpha-Hexylcinnamaldehyde [(3E)-3-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)norbornan-2-yliden e]methyl]phenyl]methylidene]-7,7-dimethyl-2-oxo-norbornan-1-yl]methane sulfonic acid Phenylacetone

4''-METHYLBENZYLIDENE CAMPHOR(MBC 95)

NEO-HELIOPAN

METHYLBENZYLIDENECAMPHOR

MEXORYLSD

3-(4-METHYLBENZYLIDINE)CAMPHOR

(+-)-1,7,7-Trimethyl-3-[(4-methylphenyl)methylen]bicyclo[2.2.1]heptan-2-on

(1S,2Z,4R)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]-3-bicyclo[2.2.1]heptanone

(2Z)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one

3-(4-Methylbenzylidene)-camphor, 99+%

Bicyclo2.2.1heptan-2-one, 1,7,7-trimethyl-3-(4-methylphenyl)methylene-

MBC 95

4-Methylbenzylidencamphor

(Z)-1,7,7-triMethyl-3-(4-Methylbenzylidene)bicyclo[2.2.1]heptan-2-one

1,7,7-Trimethyl-3-(4-methylbenzylidene)-norbornan-2-one

1,7,7-trimethyl-3-[(4-methylphenyl)methylene]-Bicyclo[2.2.1]heptan-2-one

4-METHYLBENZYLIDENE CAMPHOR

Contralum 6300

Zinc01481820

Methyl Benzylidene Camphor (200 mg)

3-(4-METHYLBENZYLIDEN)CAMPHOR

3-(4'-METHYL)BENZYLIDENE-BORNAN-2-ONE

3-(4-METHYLZYLIDENE)-BRONAN-2-ONE

3-(4-METHYLZYLIDENE)CAMPHOR

(3e)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one

EUSOLEX(R) 6300

EUSOLEX 6300

NEO HELIOPAN MBC

PARSOL 5000

4-Methyl-benzylidene camphor (4-MBC) @100 μg/mL in MeOH

Enzacamene

3-(4-Methylbenzylidene)camphor Solution in Methanol/THF/Water, 100μg/mL

JADEWIN 4-MBC

36861-47-9 3-(4'-Methylbenzylidene)camphor

The chemical name is 3-(4-methylbenzene) -camphor

UV 4MBC

UV ABSORBER TRUELICHT UV 5000

1,7,7-Trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one

Azilsartan Impurity 86

3-4-METHYLBENZYLIDENE CAMPHOR UVB Absorbent

3-(4-Methylbenzylidene)camphor in methanol

36861-47-9

36861-47-1

861-47-9

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

cosmetic raw material

UV-Absorber