ChemicalBook > CAS DataBase List > 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER

2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER

Product Name: 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
CAS No.: 445264-61-9
Chemical Name: 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
Synonyms: 2-(-2-Methoxypyridin-5-yl) Pyridine;2-Methoxypyridine-5-boronic acid pinacoL;6-Methoxy-pyridine-3-boronic acid picol ester;6-Methoxy-3-pyridylboronic Acid Pinacol Ester;2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER;2-methoxyl-5-pyridineboronic acid pinacol ester;6-METHOXYPYRIDINE-3-BORONIC ACID, PINACOL ESTER;2-METHOXY-5-PYRIDINEBORONIC ACID, PINACOL ESTER;(2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester;2-Methoxypyridine-5-boronic acid pinacol ester 97%
CBNumber: CB9367724
Molecular Formula: C12H18BNO3
Formula Weight: 235.09
MOL File: 445264-61-9.mol

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2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER Property

Melting point:: 47-51 °C(lit.)
Boiling point:: 102°C/0.08mmHg(lit.)
Density: 1.06±0.1 g/cm3(Predicted)
Flash point:: 216 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Water Solubility: Soluble in water
form: powder to crystal
pka: 3.39±0.12(Predicted)
color: White to Almost white
CAS DataBase Reference: 445264-61-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 636029
Product name: 2-Methoxypyridine-5-boronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $32
Updated: 2023/06/20

Sigma-Aldrich

Product number: 636029
Product name: 2-Methoxypyridine-5-boronic acid pinacol ester
Purity: 97%
Packaging: 5g
Price: $152
Updated: 2023/01/07

TCI Chemical

Product number: M2650
Product name: 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: M2650
Product name: 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $130
Updated: 2025/07/31

TRC

Product number: M267115
Product name: (2-Methoxypyridin-5-yl)boronicAcidPinacolEster
Packaging: 1g
Price: $130
Updated: 2021/12/16

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2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production

Uses

(2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester is used in the design and synthesis of oxazolidinone antibacterial agents. As well, it is used in the synthesis of [3,2-b]pyridines.

Uses

2-Methoxypyridine-5-boronic acid pinacol ester is used in the design and synthesis of oxazolidinone antibacterial agents. As well, it is used in the synthesis of [3,2-b]pyridines.

Synthesis

13472-85-0

73183-34-3

445264-61-9

Step 1: 5-bromo-2-methoxypyridine (55 g, 0.29 mol), pinacol ester of bisboronic acid (90 g, 0.35 mol), potassium acetate (57 g, 0.58 mol) and bis(triphenylphosphine)palladium(II) chloride (2.2 g, 3 mmol) were dissolved in anhydrous dioxane (500 mL) under nitrogen protection. The reaction mixture was heated and stirred at 108 °C overnight. Upon completion of the reaction, the mixture was concentrated and purified by column chromatography using hexane/ethyl acetate as eluent to afford pinacol ester of 6-methoxypyridine-3-boronic acid (58 g, 84% yield).

References

[1] Patent: US9249156, 2016, B2. Location in patent: Page/Page column 36
[2] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 26; 28
[3] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 151
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 12, p. 2496 - 2500
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 19, p. 6477 - 6485

2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER manufacturers

Dideu Industries Group Limited

Product: 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 445264-61-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 445264-61-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 445264-61-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

445264-61-9, 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTERRelated Search:

p-Anisidine p-Anisaldehyde 4-Methoxybenzylchloride Pyridine 3-(METHOXYMETHOXY)BENZALDEHYDE (Trifluoromethoxy)benzene Bis(pinacolato)diboron Tris(trimethylsilyl)phosphate Dimethyl succinate EPA Anisole Methyl acrylate 4-Methoxyphenylacetone 3-Pyridylboronic acid 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-BENZYLOXYPYRIDINE-5-BORONIC ACID, PINACOL ESTER 2-(CYCLOPROPYLMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-ETHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

2-methoxyl-5-pyridineboronic acid pinacol ester

2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER

2-METHOXY-5-PYRIDINEBORONIC ACID, PINACOL ESTER

2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

6-METHOXYPYRIDINE-3-BORONIC ACID, PINACOL ESTER

(2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester

2-Methoxy-5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine (2-Methoxy-5-pyridineboronic acid pinacol ester)

2-Methoxy-5-pyridineboronic acid pinacol ester, 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

6-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2-Methoxy-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

6-Methoxy-pyridine-3-boronic acid picol ester

2-Methoxyl-5-pyridineboronic acid pinacol ester 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2-Methoxypyridine-5-boronic acid pinacol ester 97%

2-(6-Methoxypyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolan

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine &gt

2-Methoxypyridine-5-boronic acid pinacoL

Pyridine, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-(6-Methoxy-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

6-Methoxy-3-pyridylboronic Acid Pinacol Ester

2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER ISO 9001：2015 REACH

2-(-2-Methoxypyridin-5-yl) Pyridine

2-Methoxypyridine-5-boronic acid pinacol ester,2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine - [M23718]

445264-61-9

408502-23-9

Boronic Acids and Derivatives

Boronate Esters

Organometallic Reagents

Heteroaryl

Boronic Ester

CHIRAL CHEMICALS