ChemicalBook > CAS DataBase List > D(+)-Malic acid

D(+)-Malic acid

Product Name
D(+)-Malic acid
CAS No.
636-61-3
Chemical Name
D(+)-Malic acid
Synonyms
D-MALIC ACID;(R)-MALIC ACID;D-(+)-MALIC ACID;(2R)-2-Hydroxybutanedioic acid;D-(+)-MaL;D(+)-Malic;D-APPLE ACID;(R)-malicaci;l(+)-malicaci;D-Aepfelsaeure
CBNumber
CB9373789
Molecular Formula
C4H6O5
Formula Weight
134.09
MOL File
636-61-3.mol
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D(+)-Malic acid Property

Melting point:
98-102 °C (lit.)
alpha 
2.2 º (c=3, H2O)
Boiling point:
167.16°C (rough estimate)
Density 
1.60
refractive index 
6.5 ° (C=10, Acetone)
storage temp. 
Store below +30°C.
solubility 
Soluble in methanol, ethanol, acetone, ether.
form 
Crystalline Powder
pka
3.61±0.23(Predicted)
color 
White
PH
2.2 (10g/l, H2O, 20℃)
optical activity
[α]20/D +28.0±2°, c = 5.5% in pyridine
Water Solubility 
soluble
Merck 
14,5707
BRN 
1723540
LogP
-1.370 (est)
CAS DataBase Reference
636-61-3(CAS DataBase Reference)
NIST Chemistry Reference
(r)-Hydroxybutanedioic acid(636-61-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41-36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
ON7260000
HS Code 
29181980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
02300
Product name
D-(+)-Malic acid
Purity
unnatural form, ≥97.0% (T)
Packaging
1g
Price
$34.02
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00763
Product name
D-(+)-Malic acid
Purity
for the resolution of racemates for synthesis
Packaging
5G
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
46940-U
Product name
D-Malic acid
Purity
analytical standard
Packaging
1kit
Price
$37
Updated
2024/03/01
Sigma-Aldrich
Product number
02300
Product name
D-(+)-Malic acid
Purity
unnatural form, ≥97.0% (T)
Packaging
5g
Price
$83.3
Updated
2024/03/01
TCI Chemical
Product number
M0021
Product name
D-(+)-Malic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$21
Updated
2024/03/01
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D(+)-Malic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid rece

Uses

D-(+)-Malic acid used as an acidulant and flavoring agent, food additive. And it is also used in the place of the less sour citric acid in sour sweets.

Uses

D-(+)-Malic acid can be used:

  • As a starting material for the enantioselective total synthesis of (?)-erinapyrone B.
  • As a chiral organocatalyst in the synthesis of α-aminophosphonates from various aldehydes, aniline, and diethyl phosphite.

Definition

ChEBI: An optically active form of malic acid having (R)-configuration.

Biological Activity

D-(+)-Malic acid, an active isomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport.

Synthesis

Malic acid is isolated from immature apples; industrially prepared is obtained by catalytic oxidation of benzene, then reacting with water at high temperature and high pressure to generate maleic anhydride.

in vitro

Some bacteria belonging to Arthrobacter, Brevibacterium, Corynebacterium, Pseudomonas, Bacillus, and Acinetobacter produced D-(+)-Malic acid (D-Malic acid) from Maleic acid when the cells grown in a medium containing citraconic acid are reacted aerobically with Maleic acid in the pH 7.0 phosphate buffer containing 0.1% sodium chloride.

D(+)-Malic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(-)-3-Pyrrolidinol hydrochloride (S)-(+)-3-Quinuclidinol (R)-3-Hydroxypyrrolidine (R)-(+)-1-Benzyl-3-pyrrolidinol
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View Lastest Price from D(+)-Malic acid manufacturers

Speranza Chemical Co., Ltd.
Product
D( )Malic acid 636-61-3
Price
US $0.00-0.00/KG
Min. Order
5KG
Purity
99%
Supply Ability
500kg
Release date
2023-11-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
D(+)-Malic acid 636-61-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
1000kg/month
Release date
2021-12-16
Hebei Weibang Biotechnology Co., Ltd
Product
D(+)-Malic acid 636-61-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28

636-61-3, D(+)-Malic acidRelated Search:

Folic acid D(-)-Tartaric acid Disodium succinate L-Malic acid meso-2,3-Dibromosuccinic acid Succimer Hyaluronic acid ZINC ZIRCONATE Ethyl 2-(Chlorosulfonyl)acetate Diethyl succinosuccinate Malic acid Succinic acid Citric acid DL-Malic acid D(+)-Trehalose dihydrate 4-Hydroxy-D-(-)-2-phenylglycine Oxobutanedioic acid 3,4-dihydroxybutanoic acid

  • Butanedioic acid, hydroxy-, (R)-
  • hydroxy-,(R)-Butanedioicacid
  • l(+)-malicaci
  • (R)-(+)-MALIC ACID
  • (R)-MALIC ACID
  • Malic Acid Impurity 3
  • (2R)-2-hydroxybutanedioate
  • (+)-D-MALIC ACID
  • D-(+)-MALIC ACID
  • D-MALIC ACID
  • D-(+)-APPLE ACID
  • D-APPLE ACID
  • MALIC ACID, D-(+)-
  • (r)-hydroxybutanedioic acid
  • (R)-(+)-HYDROXYSUCCINIC ACID
  • (R)-HYDROXYSUCCINIC ACID
  • (R)-2-HYDROXY-SUCCINIC ACID
  • R(+)-2-HYDROXYSUCCINIC ACID
  • (R)-2-HYDROXYBUTANEDICARBOXYLIC ACID
  • D-MALIC ACID 100MG NEAT
  • D-(+)-MALIC ACID 99%
  • D-(+)-Malic acid, 98+%
  • D-Aepfelsaeure
  • D(+)-Malic
  • Butanedioic acid, hydroxy-, (2R)-
  • MALIC ACID, D-(+)-(P)
  • D-MALIC ACID / (R)-(+)-HYDROXYSUCCINIC ACID
  • D-HYDROXYBUTANEDIOIC ACID
  • D-HYDROXYSUCCINIC ACID
  • D-(+)-Malic acid ,99%
  • D-(+)-Malic acid,(R)-(+)-2-Hydroxysuccinic acid, D-Hydroxybutanedioic acid
  • D-(+)-MALIC ACID FOR THE RESOLUTION OF R
  • (R)-(+)-2-Hydroxysuccinic acid, D-(+)-Malic acid, D-Hydroxybutanedioic acid
  • (R)-(+)-2-Hydroxysuccinic acid, D-Hydroxybutanedioic acid
  • (2R)-2-Hydroxybutanedioic acid
  • (2R)-Malic acid
  • D-(+)-2-Hydroxysuccinic acid
  • [R,(+)]-2-Hydroxybutanedioic acid
  • D-(+)-Malic acid unnatural forM, >=97.0% (T)
  • D-(+)-Malic Acid, 97+%
  • Butanedioic acid, 2-hydroxy-, (2R)-
  • D-(+)-MalicAcid&gt
  • D-(+)-MaL
  • (R)-malicaci
  • dextro-malic acid
  • (+)-Malic acid
  • 636-61-3
  • 480-40-4
  • Asymmetric Synthesis
  • Optical Resolution
  • Chiral Building Blocks
  • Carboxylic Acids (Chiral)
  • for Resolution of Bases
  • Chiral Resolution Reagents
  • Chiral Resolving Reagents
  • Chiral Compound
  • Aliphatics
  • Chiral Reagents