ChemicalBook > CAS DataBase List > 5-FLUORO-2-METHOXYACETOPHENONE

5-FLUORO-2-METHOXYACETOPHENONE

Product Name: 5-FLUORO-2-METHOXYACETOPHENONE
CAS No.: 445-82-9
Chemical Name: 5-FLUORO-2-METHOXYACETOPHENONE
Synonyms: 5′Albb-004400;-Fluoro-2′5-FLUORO-2-METHOXYACETOPHENONE;5'-Fluoro-2'-methoxyacetophenone;5-FLOURO-2- METHOXY ACETOPHENONE;1-(5-Fluoro-2-methoxyphenyl)ethanon;1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE;1-(5-fluoro-2-methoxyphenyl)ethan-1-one;Ethanone, 1-(5-fluoro-2-methoxyphenyl)-
CBNumber: CB9383272
Molecular Formula: C9H9FO2
Formula Weight: 168.16
MOL File: 445-82-9.mol

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5-FLUORO-2-METHOXYACETOPHENONE Property

Melting point:: 23 °C
Boiling point:: 132 °C(Press: 13 Torr)
Density: 1.1880 g/mL at 25 °C
refractive index: 1.5180
Flash point:: 110 °C
storage temp.: Sealed in dry,Room Temperature
form: liquid
Appearance: Colorless to off-white <23°C Solid,>23°C Liquid
CAS DataBase Reference: 445-82-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-22
Safety Statements: 26-36/37/39-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 683299
Product name: 5′-Fluoro-2′-methoxyacetophenone
Purity: 97%
Packaging: 1g
Price: $85.6
Updated: 2023/06/20

TRC

Product number: F599333
Product name: 5''-Fluoro-2''-methoxyacetophenone
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC9857
Product name: 5'-Fluoro-2'-methoxyacetophenone
Purity: 98%
Packaging: 1g
Price: $38
Updated: 2021/12/16

AK Scientific

Product number: X8297
Product name: 5'-Fluoro-2'-methoxyacetophenone
Packaging: 5g
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 036402
Product name: 1-(5-Fluoro-2-methoxyphenyl)ethanone
Packaging: 500mg
Price: $252
Updated: 2021/12/16

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5-FLUORO-2-METHOXYACETOPHENONE Chemical Properties,Usage,Production

Uses

5′-Fluoro-2′-methoxyacetophenone is used to synthesize other fluorinated compounds.

Reactions

5′-Fluoro-2′-methoxyacetophenone is a reactive intermediate that undergoes an electrophilic aromatic substitution with methanol to form the corresponding fluorinated methoxyacetophenone.

Synthesis

394-32-1

77-78-1

445-82-9

Step 2. A 4.1:1 mixture of 5-fluoro-2-hydroxyacetophenone (10.4 g, 61.8 mmol) and dimethyl sulfate (2.54 g, 16.5 mmol) was dissolved in acetone (50 mL) and potassium carbonate (2.50 g, 18.1 mmol) was added. Dimethyl sulfate (0.25 mL, 2.6 mmol) was then added. The reaction mixture was heated to reflux for 18 h. After cooling to room temperature, water (20 mL) was added. The mixture was stirred for 3 hours at room temperature and then partitioned between dichloromethane (50 mL) and brine (50 mL). The organic layer was separated and the aqueous layer was extracted with dichloromethane (3 x 50 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. 13.0 g (98% yield, 97% area) of 2-methoxy-5-fluoroacetophenone was obtained as a yellow oil.NMR (400 MHz, CDCl3) δppm: 2.64 (s, 3H), 3.92 (s, 3H), 6.94 (dd, J=9.09,4.04 Hz, 1H), 7.18 (ddd, J=9.09, 7.33,3.28 Hz, 1H), 7.48 (dd, J=8.97,3.16 Hz, 1H); HPLC retention time: 3.39 min; MS (ESI+) C9H9FO2 m/z 169.1 (M+H)+.

References

[1] Patent: WO2018/161008, 2018, A1. Location in patent: Paragraph 00217
[2] Journal of Organic Chemistry, 1960, vol. 25, p. 1016 - 1020
[3] Patent: US4251546, 1981, A

5-FLUORO-2-METHOXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-FLUORO-2-METHOXYACETOPHENONE Suppliers

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View Lastest Price from 5-FLUORO-2-METHOXYACETOPHENONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-FLUORO-2-METHOXYACETOPHENONE 445-82-9
Price: US $1.00-28.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20000KG
Release date: 2024-07-29

Career Henan Chemical Co

Product: 1-(5-Fluoro-2-methoxyphenyl)ethanone 445-82-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-02-14

445-82-9, 5-FLUORO-2-METHOXYACETOPHENONERelated Search:

Methyl 5-fluoro-2-methyl-3-nitrobenzoate METHYL 2-METHYL-5-FLUOROBENZOATE 5-Fluoro-2-methylbenzoic acid 5-FLUORO-2-METHOXYBENZONITRILE 5-Fluoro-2-methoxyphenyl acetic acid 5-Fluoro-2-methoxyphenol 5-FLUORO-2-METHOXYBENZALDEHYDE 6-Fluoro-4-chromanone 2-Fluoro-4-methoxyacetophenone 4-FLUORO-2-METHOXYACETOPHENONE 4'-FLUORO-3'-METHOXYACETOPHENONE,4-FLUORO-3-METHOXYACETOPHENONE,4'-Fluoro-3'-methoxyacetophenone 99+% 2'-FLUORO-6'-METHOXYACETOPHENONE,2-FLUORO-6-METHOXYACETOPHENONE 2,4-DIFLUORO-3-METHOXY ACETOPHENONE 2',6'-DIFLUORO-4'-METHOXYACETOPHENONE 3'-CHLORO-5'-FLUORO-4'-METHOXYACETOPHENONE 3-Fluoro-4-methoxyacetophenone 2'-Methoxyacetophenone 6-FLUORO-3-FORMYLCHROMONE

1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE

5-FLUORO-2-METHOXYACETOPHENONE

1-(5-Fluoro-2-methoxyphenyl)ethanon

Albb-004400

1-(5-fluoro-2-methoxyphenyl)ethan-1-one

JR-8527, 1-(5-Fluoro-2-methoxyphenyl)ethanone, 97%

Ethanone, 1-(5-fluoro-2-methoxyphenyl)-

5-FLOURO-2- METHOXY ACETOPHENONE

5&#8242

-Fluoro-2&#8242

5'-Fluoro-2'-methoxyacetophenone

5′-Fluoro-2′-methoxyacetophenone, CAS 445-82-9

445-82-9

Building Blocks

Carbonyl Compounds

Organic Building Blocks

Ketones

Aromatic Acetophenones & Derivatives (substituted)

Fluorine series