ChemicalBook > CAS DataBase List > D(+)-Galactosamine hydrochloride

D(+)-Galactosamine hydrochloride

Product Name
D(+)-Galactosamine hydrochloride
CAS No.
1772-03-8
Chemical Name
D(+)-Galactosamine hydrochloride
Synonyms
Galactosamine;D-GALACTOSAMINE HYDROCHLORIDE;GALACTOSAMINE HCL;D-GALACTOSAMINE HCL;GALACTOSAMINE HYDROCHLORIDE;2-Amino-2-Deoxy-D-Galactopyranose;D-GALN HCL;CHONDROSAMINE;D-GalactosaMine HC1;actosamine hydrochL
CBNumber
CB9386354
Molecular Formula
C6H14ClNO5
Formula Weight
215.63
MOL File
1772-03-8.mol
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D(+)-Galactosamine hydrochloride Property

Melting point:
182-185 °C (dec.)(lit.)
alpha 
96 º (589nm c=1,H2O,24 hrs)
Density 
1.3965 (rough estimate)
refractive index 
96 ° (C=1, H2O)
storage temp. 
room temp
solubility 
H2O: 50 mg/mL, clear, colorless
form 
White solid
color 
White to Off-White
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,4334
BRN 
3697825
Stability:
Moisture Sensitive
CAS DataBase Reference
1772-03-8(CAS DataBase Reference)
EPA Substance Registry System
D-Galactose, 2-amino-2-deoxy-, hydrochloride (1772-03-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36/37/39-27-26
WGK Germany 
3
RTECS 
LW5500000
F 
3-10
TSCA 
Yes
HS Code 
29329970
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
34539-M
Product name
D(+)Galactosamine, Hydrochloride - CAS 1772-03-8 - Calbiochem
Packaging
34539-1GM
Price
$92.2
Updated
2024/03/01
Sigma-Aldrich
Product number
1287722
Product name
Galactosamine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$536
Updated
2024/03/01
Sigma-Aldrich
Product number
34539-M
Product name
D(+)Galactosamine, Hydrochloride - CAS 1772-03-8 - Calbiochem
Packaging
1G
Price
$71.7
Updated
2022/05/15
Alfa Aesar
Product number
L07462
Product name
D-Galactosamine hydrochloride, 98%
Packaging
250mg
Price
$23.8
Updated
2021/12/16
Alfa Aesar
Product number
L07462
Product name
D-Galactosamine hydrochloride, 98%
Packaging
1g
Price
$79.2
Updated
2021/12/16
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D(+)-Galactosamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

D-(+)-Galactosamine (D-chondrosamine) is used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs.

Uses

D-(+)-Galactosamine hydrochloride has been used to:

  • induce livery injury
  • inflammatory liver injury
  • acute liver failure (ALF) in mice

Uses

Specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Galactosamine (D-GalN) is synthesized from galactose and is potential hepatotoxic agent. D-GalN in combination with lipopolysaccharide leads to the development of lethal liver injury and hepatic failure. It sensitizes cells to the toxic effects of the cytokine in particular the tumor necrosis factor(TNF).

Synthesis

A preparation process of D-galactosamine hydrochloride, adding 500ml absolute ethanol into a 1000ml three-necked flask with a reflux condenser, a stirrer and a thermometer, stirring at room temperature and adding 100g of dimethyl dodecyl respectively Tetradecylamine and 500g of solid-supported silica were heated to 110°C within 30 minutes, kept in reflux for 5 hours and then lowered to 29°C, filtered and dried to obtain 589g of organic amine solid-supported catalyst. In a 1000ml three-necked flask with a stirrer and a thermometer, 190g of 5-methyltryptamine hydrochloride and 600ml of dimethylamide were respectively added, 59g of organic amine solid-supported catalyst and 150g of chloropropene were added, and the reaction was carried out for eight hours at room temperature. Liquid filtration, the obtained filtrate was evaporated to dryness and dissolved in 1150ml of isopropanol, and 89ml of 36wt% hydrochloric acid was added to hydrochloride to obtain 130.32g of white crystals of 2-amino-2-deoxy-D-galactose hydrochloride with a yield of 42.05%.

Purification Methods

Dissolve the hydrochloride in a small volume of H2O. Then add three volumes of EtOH, followed by acetone until faintly turbid and keep overnight in a refrigerator. [Roseman & Ludoweig J Am Chem Soc 76 301 1954, Beilstein 4 IV 2024.]

D(+)-Galactosamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from D(+)-Galactosamine hydrochloride manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
D(+)-Galactosamine hydrochloride 1772-03-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000
Release date
2023-08-11
Hebei Weibang Biotechnology Co., Ltd
Product
D(+)-Galactosamine hydrochloride 1772-03-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
D(+)-Galactosamine hydrochloride 1772-03-8
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-14

1772-03-8, D(+)-Galactosamine hydrochlorideRelated Search:

D-Galactose D-(+)-GALACTOSE 4-AMINOAZOBENZENE HYDROCHLORIDE D-Glucosamine hydrochloride Pectinase Glycine Galacto-oligosaccharides ALTRENOGEST Topotecan hydrochloride D-GALACTOSE 1-[2-(2-AZIDOETHOXY)ETHOXYETHYL]-2,3,4,6-TETRA-O-ACETATE 6-Aminocaproic acid TRIGALACTURONIC ACID Tris(hydroxymethyl)aminomethane KANOSAMINE, HYDROCHLORIDE D-Mannosamine hydrochloride C08349 Tryptamine 5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-galactosaminide

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