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CASPASE INHIBITOR3

Product Name
CASPASE INHIBITOR3
CAS No.
187389-53-3
Chemical Name
CASPASE INHIBITOR3
Synonyms
N-BOC-D-FMK;CASPASE INHIBITOR3;Boc-D-FMK, caspase inhibitor;Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone;Boc-Asp(OMe)-fluoromethyl ketone, 10 mM in DMSO;Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF;N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone;Methyl (S)-3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;(S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester
CBNumber
CB9390865
Molecular Formula
C11H18FNO5
Formula Weight
263.26
MOL File
187389-53-3.mol
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CASPASE INHIBITOR3 Property

Boiling point:
383.5±37.0 °C(Predicted)
Density 
1.150±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
-20°C
solubility 
Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.
form 
Powder
pka
10.12±0.46(Predicted)
color 
Off-white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B2682
Product name
Boc-Asp(OMe)-fluoromethyl ketone
Purity
≥90% (TLC), solid
Packaging
3mg
Price
$1020
Updated
2024/03/01
Alfa Aesar
Product number
J65812
Product name
N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone
Packaging
5mg
Price
$463.65
Updated
2024/03/01
Cayman Chemical
Product number
16118
Product name
Boc-D-FMK
Purity
≥95%
Packaging
500μg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
16118
Product name
Boc-D-FMK
Purity
≥95%
Packaging
1mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
16118
Product name
Boc-D-FMK
Purity
≥95%
Packaging
5mg
Price
$388
Updated
2024/03/01
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CASPASE INHIBITOR3 Chemical Properties,Usage,Production

Uses

N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone is used as a novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology and irreversibly binds to activated caspases to block apoptosis. It is useful for in vitro and in vivo applications.

Uses

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

Biochem/physiol Actions

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.

CASPASE INHIBITOR3 Preparation Products And Raw materials

Raw materials

Preparation Products

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CASPASE INHIBITOR3 Suppliers

China 42 India 1 Japan 1 Switzerland 1 United Kingdom 1 United States 13 Global 59
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187389-53-3, CASPASE INHIBITOR3Related Search:

SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE Tris(2,4-pentanedionato)chroMiuM(III) Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Tosylmethyl isocyanide Benzyl isocyanide Aluminum acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE COBALT(II) ACETYLACETONATE TERT-BUTYL ISOCYANIDE METHYL ISOCYANOACETATE N-BUTYLISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) PHENYLSELENOL Ethyl isocyanoacetate Cupric acetylacetonate

  • CASPASE INHIBITOR3
  • (3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester
  • N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone
  • (S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate
  • N-BOC-D-FMK
  • Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF
  • Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)-
  • Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone
  • inhibit,broad,Boc Asp(OMe) fluoromethyl ketone,Caspase,Fas-induced,Inhibitor,LDH,oxidative,apoptosis,spontaneous,BocAsp(OMe)fluoromethyl ketone,rupture
  • Methyl (S)-3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate
  • Boc-D-FMK, caspase inhibitor
  • Boc-Asp(OMe)-fluoromethyl ketone, 10 mM in DMSO
  • 187389-53-3
  • C11H18NO5F
  • Caspase/Related Products
  • Apoptosis