CASPASE INHIBITOR3
- Product Name
- CASPASE INHIBITOR3
- CAS No.
- 187389-53-3
- Chemical Name
- CASPASE INHIBITOR3
- Synonyms
- N-BOC-D-FMK;CASPASE INHIBITOR3;Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone;Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF;N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone;Methyl (S)-3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;(S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester;Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)-;inhibit,broad,Boc Asp(OMe) fluoromethyl ketone,Caspase,Fas-induced,Inhibitor,LDH,oxidative,apoptosis,spontaneous,BocAsp(OMe)fluoromethyl ketone,rupture
- CBNumber
- CB9390865
- Molecular Formula
- C11H18FNO5
- Formula Weight
- 263.26
- MOL File
- 187389-53-3.mol
CASPASE INHIBITOR3 Property
- Boiling point:
- 383.5±37.0 °C(Predicted)
- Density
- 1.150±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- -20°C
- solubility
- Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.
- form
- Powder
- pka
- 10.12±0.46(Predicted)
- color
- Off-white
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- B2682
- Product name
- Boc-Asp(OMe)-fluoromethyl ketone
- Purity
- ≥90% (TLC), solid
- Packaging
- 3mg
- Price
- $1020
- Updated
- 2024/03/01
- Product number
- J65812
- Product name
- N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone
- Packaging
- 5mg
- Price
- $463.65
- Updated
- 2024/03/01
- Product number
- 16118
- Product name
- Boc-D-FMK
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16118
- Product name
- Boc-D-FMK
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 16118
- Product name
- Boc-D-FMK
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $388
- Updated
- 2024/03/01
CASPASE INHIBITOR3 Chemical Properties,Usage,Production
Uses
N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone is used as a novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology and irreversibly binds to activated caspases to block apoptosis. It is useful for in vitro and in vivo applications.
Uses
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .
Biochem/physiol Actions
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.
CASPASE INHIBITOR3 Preparation Products And Raw materials
Raw materials
Preparation Products
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