ChemicalBook > CAS DataBase List > CASPASE INHIBITOR3

CASPASE INHIBITOR3

Product Name: CASPASE INHIBITOR3
CAS No.: 187389-53-3
Chemical Name: CASPASE INHIBITOR3
Synonyms: N-BOC-D-FMK;CASPASE INHIBITOR3;Boc-D-FMK, caspase inhibitor;Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone;Boc-Asp(OMe)-fluoromethyl ketone, 10 mM in DMSO;Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF;N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone;Methyl (S)-3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;(S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester
CBNumber: CB9390865
Molecular Formula: C11H18FNO5
Formula Weight: 263.26
MOL File: 187389-53-3.mol

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CASPASE INHIBITOR3 Property

Boiling point:: 383.5±37.0 °C(Predicted)
Density: 1.150±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: -20°C
solubility: Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.
form: Powder
pka: 10.12±0.46(Predicted)
color: Off-white
InChI: InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
InChIKey: MXOOUCRHWJYCAL-ZETCQYMHSA-N
SMILES: C(OC)(=O)C[C@H](NC(OC(C)(C)C)=O)C(=O)CF

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B2682
Product name: Boc-Asp(OMe)-fluoromethyl ketone
Purity: ≥90% (TLC), solid
Packaging: 3mg
Price: $893
Updated: 2025/07/31

Cayman Chemical

Product number: 16118
Product name: Boc-D-FMK
Purity: ≥95%
Packaging: 500μg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 16118
Product name: Boc-D-FMK
Purity: ≥95%
Packaging: 1mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 16118
Product name: Boc-D-FMK
Purity: ≥95%
Packaging: 5mg
Price: $388
Updated: 2024/03/01

TRC

Product number: B646230
Product name: Boc-D-FMK
Packaging: 10mg
Price: $655
Updated: 2021/12/16

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CASPASE INHIBITOR3 Chemical Properties,Usage,Production

Uses

N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone is used as a novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology and irreversibly binds to activated caspases to block apoptosis. It is useful for in vitro and in vivo applications.

Uses

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

Biochem/physiol Actions

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.

IC 50

Caspase

CASPASE INHIBITOR3 Preparation Products And Raw materials

Raw materials

Preparation Products

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187389-53-3, CASPASE INHIBITOR3Related Search:

SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE Tris(2,4-pentanedionato)chroMiuM(III) Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Tosylmethyl isocyanide Benzyl isocyanide Aluminum acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE COBALT(II) ACETYLACETONATE TERT-BUTYL ISOCYANIDE METHYL ISOCYANOACETATE N-BUTYLISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) PHENYLSELENOL Ethyl isocyanoacetate Cupric acetylacetonate

CASPASE INHIBITOR3

(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester

N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone

(S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate

N-BOC-D-FMK

Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF

Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)-

Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone

inhibit,broad,Boc Asp(OMe) fluoromethyl ketone,Caspase,Fas-induced,Inhibitor,LDH,oxidative,apoptosis,spontaneous,BocAsp(OMe)fluoromethyl ketone,rupture

Methyl (S)-3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate

Boc-D-FMK, caspase inhibitor

Boc-Asp(OMe)-fluoromethyl ketone, 10 mM in DMSO

187389-53-3

C11H18NO5F

Caspase/Related Products

Apoptosis