MAFP
- Product Name
- MAFP
- CAS No.
- 188404-10-6
- Chemical Name
- MAFP
- Synonyms
- MAPF;MAFP;Phosphonofluoridicacid;METHYL ARACHIDONYL FLUOROPHOSPHONATE;Methyl arachidonyl fluorophosphonate, 98%,;(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenylmethylester;METHYLPHOSPHONOFLUORIDIC ACID 5,8,11,14-EICOSATETRAENYL ESTER;5Z,8Z,11Z,14Z-EICOSATETRAENYL-PHOSPHONOFLUORIDIC ACID, METHYL ESTER;Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester;(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester
- CBNumber
- CB9395022
- Molecular Formula
- C21H36FO2P
- Formula Weight
- 370.48
- MOL File
- 188404-10-6.mol
MAFP Property
- Boiling point:
- 455.3±34.0 °C(Predicted)
- Density
- 0.960±0.06 g/cm3(Predicted)
- RTECS
- TA8108000
- Flash point:
- -16 °C
- storage temp.
- -70°C
- solubility
- DMF: 3 mg/ml; DMSO: 3 mg/ml; Ethanol: 3.5 mg/ml; Ethanol:PBS (pH 7.2) 1:1: .5 mg/ml; PBS (7.2): <1 mg/ml (colloidal suspension
- form
- methyl acetate solution
- Sensitive
- Air Sensitive
Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36-66-67
- Safety Statements
- 16-26-29-33
- RIDADR
- UN 1231 3/PG 2
- WGK Germany
- 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M2939
- Product name
- Methyl arachidonyl fluorophosphonate
- Purity
- ≥98%, methyl acetate solution (10 mg/mL)
- Packaging
- 5MG
- Price
- $241
- Updated
- 2023/06/20
- Product number
- J67139
- Product name
- Methyl arachidonyl fluorophosphonate, 98%
- Packaging
- 5mg
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 70660
- Product name
- Methyl Arachidonyl Fluorophosphonate
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 70660
- Product name
- Methyl Arachidonyl Fluorophosphonate
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $119
- Updated
- 2024/03/01
- Product number
- 70660
- Product name
- Methyl Arachidonyl Fluorophosphonate
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $220
- Updated
- 2024/03/01
MAFP Chemical Properties,Usage,Production
Uses
(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester, is a cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.
Definition
ChEBI: Methyl Arachidonyl Fluorophosphonate is a phosphonic ester.
Biological Activity
Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC 50 = 2.5 nM). Also binds irreversibly to CB 1 receptors (IC 50 = 20 nM).
Biochem/physiol Actions
MAFP is a selective, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic phospholipase A2, but not secretory phospholipase A2. MAFP is also a potent acetylcholinesterase inhibitor.