ChemicalBook > CAS DataBase List > (S)-1-Boc-3-(hyroxymethyl)piperidine
(S)-1-Boc-3-(hyroxymethyl)piperidine
- Product Name
- (S)-1-Boc-3-(hyroxymethyl)piperidine
- CAS No.
- 140695-84-7
- Chemical Name
- (S)-1-Boc-3-(hyroxymethyl)piperidine
- Synonyms
- tert-butyl (S)-3-(hydroxymethyl)piperidine-1-carboxylate;(S)-N-Boc-3-piperidinemethanol;(S)-TERT-BUTYL 3-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;CAS:140695-84-7;N-BOC-(3S)-PIP(3-CH2OH);(S)-1-Boc-3-(hydroxymethyL;3-(S)-N-BOC-PIPERIDINE METHANOL;(S)-N-Boc-piperdine-3-hydroxymethyl;(S)-N-Boc-3-(hyroxymethyl)piperidine;(S)-1-BOC-3-(HYROXYMETHYL)PIPERIDINE
- CBNumber
- CB9407028
- Molecular Formula
- C11H21NO3
- Formula Weight
- 215.29
- MOL File
- 140695-84-7.mol
More
Less
(S)-1-Boc-3-(hyroxymethyl)piperidine Property
- Melting point:
- 96-98 °C
- Boiling point:
- 308.0±15.0 °C(Predicted)
- Density
- 1.059±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.93±0.10(Predicted)
- form
- Powder
- color
- White
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h9,13H,4-8H2,1-3H3/t9-/m0/s1
- InChIKey
- OJCLHERKFHHUTB-VIFPVBQESA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC[C@H](CO)C1
- CAS DataBase Reference
- 140695-84-7(CAS DataBase Reference)
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- B656623
- Product name
- (S)-1-BOC-3-(Hydroxymethyl)piperidine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
AK Scientific
- Product number
- U440
- Product name
- (S)-1-Boc-3-(hydroxymethyl)piperidine
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR15674
- Product name
- (3S)-3-(Hydroxymethyl)piperidine,N-BOCprotected
- Packaging
- 25g
- Price
- $173
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H29-1-X9
- Product name
- (3S)-3-(Hydroxymethyl)piperidine, N-Boc protected
- Packaging
- 25g
- Price
- $191
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 073565
- Product name
- (S)-1-Boc-3-(Hydroxymethyl)piperidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $200
- Updated
- 2021/12/16
More
Less
(S)-1-Boc-3-(hyroxymethyl)piperidine Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
(S)-1-Boc-3-(hydroxymethyl)piperidine is used as pharmaceutical intermediate.
Synthesis
163438-09-3
116574-71-1
The general procedure for the synthesis of tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate from (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylate is as follows: Example 58: Synthesis of N-(2-methylpropyl)-N-(3,5-dichlorophenylmethyl)-(3R)-piperidin-3-ylmethylamine 1.5L-tartrate: (i) Borane-tetrahydrofuran complex (1M solution of THF, 65.4 ml, 65.4 mmol, 3 eq.) was slowly added dropwise to a solution of (R)-N-Boc-piperidine-3-carboxylic acid (5 g, 21.8 mmol, 1 eq.) in THF (50 ml) at room temperature. The reaction mixture was stirred at room temperature for 16 hours. Subsequently, the solution was cooled to 0°C and hydrolyzed by careful addition of 2N aqueous sodium hydroxide solution (250 ml). The hydrolyzed mixture was heated and refluxed for 48 hours. After completion of the reaction, the mixture was again cooled to 0°C and extracted with ether (3 x 100 ml). The organic layers were combined, washed with brine (100 ml), dried over magnesium sulfate, filtered and concentrated in vacuum. The residue was purified by fast chromatography using isohexane solution of 50-70% ethyl acetate as eluent to give the title compound tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate (4.56 g, 98% yield). 1H NMR (300 MHz, CDCl3) δ: 4.0-2.7 (6H, br m), 2.17-1.19 (5H, br m), 1.46 (9H, s).
References
[1] Patent: WO2005/118531, 2005, A1. Location in patent: Page/Page column 74
[2] Patent: WO2006/12308, 2006, A1. Location in patent: Page/Page column 68
[3] Patent: WO2017/103611, 2017, A1. Location in patent: Paragraph 00298
(S)-1-Boc-3-(hyroxymethyl)piperidine Preparation Products And Raw materials
Raw materials
Ethanol
D-(-)-Tartaric Acid
Sodium chloride
Di-tert-butyl dicarbonate
Sodium borohydride
Tetrahydrofuran
Diethyl ether
Ammonium chloride
Lithium Aluminum Hydride
Dichloromethane
Ethyl nipecotate
Sodium hydroxide
L(+)-Tartaric acid
Magnesium sulfate
Preparation Products
More
Less
(S)-1-Boc-3-(hyroxymethyl)piperidine Suppliers
- Tel
- 0512-68323967 18015559028
- Fax
- +86-512-69200360
- sales@iticmedchem.com
- Country
- China
- ProdList
- 506
- Advantage
- 61
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 21-54820552 18964669552
- Fax
- 086-21-64964478
- 188738128@qq.com
- Country
- China
- ProdList
- 310
- Advantage
- 66
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11598
- Advantage
- 64
- Tel
- +86-28-86127071
- Fax
- +86-28-86127072
- info@sino-produce.com
- Country
- China
- ProdList
- 406
- Advantage
- 66
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16075
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11705
- Advantage
- 57
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 18606289633 15862625988
- Fax
- 0512-58813106
- sales@clentchem.com
- Country
- China
- ProdList
- 157
- Advantage
- 60
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- +86 (21) 6715-7650
- Fax
- +86 (21) 6715-7651
- sheepchem@163.com
- Country
- China
- ProdList
- 994
- Advantage
- 60
- Tel
- 021-60451683 15021268886
- Fax
- +86-21-60451682
- sales@arborchemical.com
- Country
- China
- ProdList
- 896
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 0512-66585217 13962137180
- Fax
- 0512-82177549
- sales@ryanchem.com
- Country
- China
- ProdList
- 384
- Advantage
- 55
- Tel
- 15928766785 15928766785
- Fax
- QQ961458712
- wupengcheng@astatech.cn
- Country
- China
- ProdList
- 1987
- Advantage
- 55
- Tel
- 031185291771 13832391721
- Fax
- 0311-67305698
- yaofeng2005@163.com
- Country
- China
- ProdList
- 978
- Advantage
- 58
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 18939837085
- Fax
- 2880152141(QQ)
- youchemicals@gmail.com
- Country
- China
- ProdList
- 1839
- Advantage
- 55
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9979
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-57790084; 13918007836
- Fax
- 021-51685238
- sales@hoborchem.com
- Country
- China
- ProdList
- 392
- Advantage
- 60
- Tel
- 20-66003216 18666003216
- Fax
- +86-20-28069063
- info@porsefinechemical.com
- Country
- China
- ProdList
- 1941
- Advantage
- 62
- Tel
- 023-13650506873 19923294409
- xingcanyaoye@sina.com
- Country
- China
- ProdList
- 1604
- Advantage
- 58
- Tel
- 021-20962833 15316628753
- Fax
- 021-2096-2832
- sales@pansopharm.com
- Country
- China
- ProdList
- 724
- Advantage
- 60
- Tel
- 028-87078428 028-87074958
- Fax
- 8772-8116
- chengzhenyong@cdfirster.com
- Country
- China
- ProdList
- 2598
- Advantage
- 60
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4942
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 010-1234567 18521000990
- Fax
- 86-021-33275113
- sonyuanchemical@163.com
- Country
- China
- ProdList
- 6479
- Advantage
- 50
- Tel
- 010-60400365-8001 15910885229
- Fax
- 010-60400361
- service@bellenchem.com
- Country
- China
- ProdList
- 4514
- Advantage
- 60
- Tel
- 28-87999436 02887999436
- Fax
- QQ:2746983436
- sales@sano-chem.com
- Country
- China
- ProdList
- 3795
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 6687
- Advantage
- 55
- Tel
- 021-68712331 3286104197
- Fax
- 021 68712331
- Country
- China
- ProdList
- 322
- Advantage
- 55
- Tel
- 0371-86658258
- Fax
- 0371-60996044
- info@coreychem.com
- Country
- China
- ProdList
- 10453
- Advantage
- 58
- Tel
- 021-52907766-8042
- Fax
- 021-52906523
- Country
- China
- ProdList
- 9941
- Advantage
- 58
- Tel
- 052386810091
- zcwy9518@yeah.net
- Country
- China
- ProdList
- 3912
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
More
Less
View Lastest Price from (S)-1-Boc-3-(hyroxymethyl)piperidine manufacturers
Career Henan Chemical Co
- Product
- (S)-1-Boc-3-(hyroxymethyl)piperidine 140695-84-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09
140695-84-7, (S)-1-Boc-3-(hyroxymethyl)piperidineRelated Search:
CARBOXYMETHYLCELLULOSE SODIUM SALT
methylol cellulose
Cyhalofop-butyl
BUTYL OLEATE
2-Hydroxyethyl methacrylate
RESMETHRIN
Tris(trimethylsilyl)phosphate
Butyl acetate
tert-Butyl acetate
tert-Butyl peroxyacetate
Buprofezin
2,2,6,6-Tetramethylpiperidinooxy
2,2,6,6-Tetramethyl-4-piperidinol
Tris(hydroxymethyl)nitromethane
Trimethylolpropane
tert-Butanol
Butyl acrylate
Tris(hydroxymethyl)aminomethane