(S)-1-Boc-3-(hyroxymethyl)piperidine
- Product Name
- (S)-1-Boc-3-(hyroxymethyl)piperidine
- CAS No.
- 140695-84-7
- Chemical Name
- (S)-1-Boc-3-(hyroxymethyl)piperidine
- Synonyms
- tert-butyl (S)-3-(hydroxymethyl)piperidine-1-carboxylate;(S)-N-Boc-3-piperidinemethanol;(S)-TERT-BUTYL 3-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;CAS:140695-84-7;N-BOC-(3S)-PIP(3-CH2OH);(S)-1-Boc-3-(hydroxymethyL;3-(S)-N-BOC-PIPERIDINE METHANOL;(S)-N-Boc-piperdine-3-hydroxymethyl;(S)-N-Boc-3-(hyroxymethyl)piperidine;(S)-1-BOC-3-(HYROXYMETHYL)PIPERIDINE
- CBNumber
- CB9407028
- Molecular Formula
- C11H21NO3
- Formula Weight
- 215.29
- MOL File
- 140695-84-7.mol
(S)-1-Boc-3-(hyroxymethyl)piperidine Property
- Melting point:
- 96-98 °C
- Boiling point:
- 308.0±15.0 °C(Predicted)
- Density
- 1.059±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.93±0.10(Predicted)
- form
- Powder
- color
- White
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h9,13H,4-8H2,1-3H3/t9-/m0/s1
- InChIKey
- OJCLHERKFHHUTB-VIFPVBQESA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC[C@H](CO)C1
- CAS DataBase Reference
- 140695-84-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B656623
- Product name
- (S)-1-BOC-3-(Hydroxymethyl)piperidine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- U440
- Product name
- (S)-1-Boc-3-(hydroxymethyl)piperidine
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR15674
- Product name
- (3S)-3-(Hydroxymethyl)piperidine,N-BOCprotected
- Packaging
- 25g
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 4H29-1-X9
- Product name
- (3S)-3-(Hydroxymethyl)piperidine, N-Boc protected
- Packaging
- 25g
- Price
- $191
- Updated
- 2021/12/16
- Product number
- 073565
- Product name
- (S)-1-Boc-3-(Hydroxymethyl)piperidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $200
- Updated
- 2021/12/16
(S)-1-Boc-3-(hyroxymethyl)piperidine Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
(S)-1-Boc-3-(hydroxymethyl)piperidine is used as pharmaceutical intermediate.
Synthesis
163438-09-3
116574-71-1
The general procedure for the synthesis of tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate from (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylate is as follows: Example 58: Synthesis of N-(2-methylpropyl)-N-(3,5-dichlorophenylmethyl)-(3R)-piperidin-3-ylmethylamine 1.5L-tartrate: (i) Borane-tetrahydrofuran complex (1M solution of THF, 65.4 ml, 65.4 mmol, 3 eq.) was slowly added dropwise to a solution of (R)-N-Boc-piperidine-3-carboxylic acid (5 g, 21.8 mmol, 1 eq.) in THF (50 ml) at room temperature. The reaction mixture was stirred at room temperature for 16 hours. Subsequently, the solution was cooled to 0°C and hydrolyzed by careful addition of 2N aqueous sodium hydroxide solution (250 ml). The hydrolyzed mixture was heated and refluxed for 48 hours. After completion of the reaction, the mixture was again cooled to 0°C and extracted with ether (3 x 100 ml). The organic layers were combined, washed with brine (100 ml), dried over magnesium sulfate, filtered and concentrated in vacuum. The residue was purified by fast chromatography using isohexane solution of 50-70% ethyl acetate as eluent to give the title compound tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate (4.56 g, 98% yield). 1H NMR (300 MHz, CDCl3) δ: 4.0-2.7 (6H, br m), 2.17-1.19 (5H, br m), 1.46 (9H, s).
References
[1] Patent: WO2005/118531, 2005, A1. Location in patent: Page/Page column 74
[2] Patent: WO2006/12308, 2006, A1. Location in patent: Page/Page column 68
[3] Patent: WO2017/103611, 2017, A1. Location in patent: Paragraph 00298
(S)-1-Boc-3-(hyroxymethyl)piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-1-Boc-3-(hyroxymethyl)piperidine Suppliers
- Tel
- 0512-68323967 18015559028
- Fax
- +86-512-69200360
- sales@iticmedchem.com
- Country
- China
- ProdList
- 506
- Advantage
- 61
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 847-367-3680
- Fax
- 847-367-3681
- sales@arkpharminc.com
- Country
- United States
- ProdList
- 1670
- Advantage
- 56
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 21-54820552 18964669552
- Fax
- 086-21-64964478
- 188738128@qq.com
- Country
- China
- ProdList
- 310
- Advantage
- 66
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11598
- Advantage
- 64
View Lastest Price from (S)-1-Boc-3-(hyroxymethyl)piperidine manufacturers
- Product
- (S)-1-Boc-3-(hyroxymethyl)piperidine 140695-84-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09