Mandelic acid
- Product Name
- Mandelic acid
- CAS No.
- 611-71-2
- Chemical Name
- Mandelic acid
- Synonyms
- D-MANDELIC ACID;(R)-(-)-MANDELIC ACID;(R)-2-HYDROXY-2-PHENYLACETIC ACID;(R)-MANDELIC ACID;2-Hydroxy-2-phenylacetic acid;(R)-(-)-2-MANDELIC ACID;(-)-MANDELIC ACID;D-(-)-MANDELIC ACID;(-)-D-MANDELIC ACID;D-ALPHA-HYDROXYPHENYLACETIC ACID
- CBNumber
- CB9411418
- Molecular Formula
- C8H8O3
- Formula Weight
- 152.15
- MOL File
- 611-71-2.mol
Mandelic acid Property
- Melting point:
- 131-133 °C(lit.)
- alpha
- -150 º (c=2.5, H2O)
- Boiling point:
- 214.6°C (rough estimate)
- Density
- 1.1677 (rough estimate)
- refractive index
- -153.5 ° (C=1, H2O)
- Flash point:
- >190℃
- storage temp.
- Store below +30°C.
- solubility
- 109.8g/l soluble
- form
- Crystalline Powder, Crystals or Flakes
- pka
- 3.37(at 25℃)
- color
- White to slightly yellow-beige
- PH
- 3.34(1 mM solution);2.75(10 mM solution);2.22(100 mM solution);
- optical activity
- [α]25/D 151°, c = 1 in ethanol
- Water Solubility
- It is partly soluble in water, freely soluble in isopropyl and ethyl alcohol.
- Sensitive
- Light Sensitive
- BRN
- 2691094
- Stability:
- Stable, but light sensitive. Combustible. Incompatible with strong bases, strong oxidizing agents.
- InChIKey
- IWYDHOAUDWTVEP-SSDOTTSWSA-N
- LogP
- 0.550 (est)
- CAS DataBase Reference
- 611-71-2(CAS DataBase Reference)
- EPA Substance Registry System
- Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.R)- (611-71-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 41-36/37/38
- Safety Statements
- 22-24/25-36-26-39-37/39
- WGK Germany
- 1
- Hazard Note
- Irritant/Light Sensitive
- TSCA
- Yes
- HS Code
- 29181980
- Toxicity
- LD50 orally in Rabbit: 5000 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.06914
- Product name
- (R)-(-)-Mandelic acid
- Purity
- for resolution of racemates for synthesis
- Packaging
- 25g
- Price
- $84.5
- Updated
- 2024/03/01
- Product number
- 8.06914
- Product name
- (R)-(-)-Mandelic acid
- Purity
- for resolution of racemates for synthesis
- Packaging
- 100g
- Price
- $163
- Updated
- 2024/03/01
- Product number
- 154210
- Product name
- (R)-(?)-Mandelic acid
- Purity
- ReagentPlus , ≥99%
- Packaging
- 5g
- Price
- $38.5
- Updated
- 2024/03/01
- Product number
- 154210
- Product name
- (R)-(?)-Mandelic acid
- Purity
- ReagentPlus , ≥99%
- Packaging
- 25g
- Price
- $109
- Updated
- 2024/03/01
- Product number
- M0662
- Product name
- D-(-)-Mandelic Acid
- Purity
- >99.0%(GC)(T)
- Packaging
- 25g
- Price
- $56
- Updated
- 2024/03/01
Mandelic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
(R)-(-)-Mandelic acid, is used as a antiseptic ingredient particularly against urinary tract infections.Mandelic acid and its derivatives are used to apply the dual activities as an antibacterial agent and as an antiaging agent. It is used as an intermediate for the synthesis of target molecules for other applications.
Uses
(R)-(?)-Mandelic acid can be used:
- As a chiral acid in the separation of diastereomeric salts for the synthesis of chiral pyridoindole based building block.
- In the study of chiral acid selectivity of poly(3,4-ethylenedioxythiophene) (PEDOT) based chiral conducting?polymers.
Uses
Antiseptic (urinary).
Definition
ChEBI: (R)-mandelic acid is the (R)-enantiomer of mandelic acid. It has a role as a human xenobiotic metabolite. It is a conjugate acid of a (R)-mandelate. It is an enantiomer of a (S)-mandelic acid.
Synthesis Reference(s)
The Journal of Organic Chemistry, 33, p. 2565, 1968 DOI: 10.1021/jo01270a105
Synthetic Communications, 18, p. 2141, 1988 DOI: 10.1080/00397918808068285
General Description
(R)-(-)-Mandelic acid, a chiral resolving agent, is also used as a building block to synthesize pharmaceutical drugs such as penicillin and cephalosporin. It can be synthesized from (R,S)-mandelonitrile with high yield and enantioselectivity using nitrilase enzyme.
Flammability and Explosibility
Non flammable
Purification Methods
Purify the mandelic acids by recrystallisation from H2O, *C6H6 or CHCl3. [Roger J Chem Soc 2168 1932,Jamison & Turner J Chem Soc 611 1942.] They have solubilities in H2O of ca 11% at 25o. [Banks & Davies J Chem Soc 73 1938.] The S-benzylisothiuronium salts has m 180o (from H2O) and [] D 25 (+) and (-) 57o (c20, EtOH) [El Masri et al. Biochem J 68 199 1958]. [Beilstein 10 IV 564.]
Mandelic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Mandelic acid Suppliers
- Tel
- --
- Fax
- --
- brunschwig@brunschwig.nl
- Country
- The Netherlands
- ProdList
- 4996
- Advantage
- 67
View Lastest Price from Mandelic acid manufacturers
- Product
- Mandelic acid 611-71-2
- Price
- US $35.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/Week
- Release date
- 2024-05-07
- Product
- Mandelic acid 611-71-2
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-05
- Product
- Mandelic acid 611-71-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20TONS
- Release date
- 2024-05-24