SENKIRKIN

Product Name: SENKIRKIN
CAS No.: 2318-18-5
Chemical Name: SENKIRKIN
Synonyms: SENKIKIN;Kushenin;renardin;SENKIRKIN;nsc-89945;RENARIDINE;Senkarkane;senkirkine;renardine[neutral];Renardine (neutral)
CBNumber: CB9427741
Molecular Formula: C19H27NO6
Formula Weight: 365.42
MOL File: 2318-18-5.mol

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SENKIRKIN Property

Melting point:: 197°C
Boiling point:: 497.19°C (rough estimate)
Density: 1.2439 (rough estimate)
refractive index: 1.5180 (estimate)
storage temp.: -20°C
form: Solid
pka: 12.67±0.40(Predicted)
color: White to off-white
LogP: 0.690 (est)
IARC: 3 (Vol. 31, Sup 7) 1987

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: 1544
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 2318-18-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89274
Product name: Senkirkine
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $708
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: CHM0032135
Product name: SENKIRKIN
Purity: 95.00%
Packaging: 5MG
Price: $495.98
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS161626
Product name: Senkirkine
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 67000
Product name: Senkirkine
Packaging: 1mg
Price: $675
Updated: 2021/12/16

AK Scientific

Product number: 2595BB
Product name: Senkirkine
Packaging: 10mg
Price: $860
Updated: 2021/12/16

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SENKIRKIN Chemical Properties,Usage,Production

Description

A further hepatotoxiC alkaloid present in Senecio kirkii Hook, S. renardi and Nardosrnia laevigata. The base has [α]²⁵_D - 16° (c 1.89, MeOH) or[α]¹⁵_D - 6.2° (c 1.91, CHCI₃). It forms colourless plates when crystallized from either Me₂CO or AcOEt and yields a picrate, m.p. 225.5-226°C and a picrolonate, m.p. 109- 110°C. The ultraviolet spectrum shows a single absorption maximum at 219 mp.. Several crystalline salts and derivatives are known, e.g. the aurichloride, m.p. 182.5-183.5°C; platinichloride, m.p. 196-7°C (dec.); bitartrate, m.p. 201°C; reineckate, m.p. 169-171°C; picrate, m.p. 225- 225.5°C; picrolonate, m.p. 138°C and the methiodide, m.p. 194-6°C (dec.). The O-acetate occurs naturally (q.v.) in Senecio kirkii.

Uses

Senkirkin, a pyrrolizidine alkaloid, occured in the aerial parts of the medicinal plant Tussilago farfara, could induce chromosome damage in human lymphocytes. Senkirkin can be metabolized by CYP3A4[1].

Definition

ChEBI: Senkirkine is a macrolide.

Safety Profile

Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox

References

Briggs, Mangan, Russell., J. Chern. Soc., 1891 (1948)
Massagetov, Kuzovkov.,J. Gen. Chern., USSR, 23, 158 (1953)
Danilova, Konovalova., ibid, 30, 1921 (1961)
Danilova, Koretskaya, Utkin., ibid, 31, 3815 (1961)
Wunderlich., Chern. Ind., 2089 (1962)
Briggs et al., J. Chern. Soc., 2492 (1965)

SENKIRKIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SENKIRKIN Suppliers

Canada 1 China 57 France 1 Germany 1 India 2 United Kingdom 2 United States 7 Global 71

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD.

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Shanghai Tauto Biotech Co., Ltd.

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Finetech Industry Limited

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Sigma-Aldrich

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Wuhan ChemFaces Biochemical Co., Ltd.

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Biyu Biotechnology (Shanghai) Co., ltd

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EMMX Biotechnology LLC

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Shanghai YuanYe Biotechnology Co., Ltd.

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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
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2318-18-5, SENKIRKINRelated Search:

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RENARIDINE

SENKIKIN

SENKIRKIN

(4Z)-4-Ethylidene-7-hydroxy-6,7,14-trimethyl-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione

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12-Hydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione

SENKIRKIN(RENARDINE)(SH)

Kushenin

nsc-89945

renardin

Renardine (neutral)

renardine[neutral]

Senecionanium, 8,12-dihydroxy-4-methyl-11,16-dioxo-

Senkarkane

senkirkine

Senkirkine (neutral)

senkirkine(neutral)

senkirkine[neutral]

trans-15-Ethylidene-12-beta-hydroxy-4,12-alpha,13-beta-trimethyl 8-oxo-4,8 secosenec-1-enine

2,9-Dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione, 4-ethylidene-7-hydroxy-6,7,14-trimethyl-, (1R,4Z,6R,7R)-

SENKIRKIN(RENARDINE)

Senkirkine 100 μg/mL in Water

Pyrrolizidine alkaloids Mixture 661 100 μg/mL in Methanol

2318-18-5

C19H28NO6

Heterocycles

Mutagenesis Research Chemicals