SENKIRKIN

Product Name: SENKIRKIN
CAS No.: 2318-18-5
Chemical Name: SENKIRKIN
Synonyms: SENKIKIN;Kushenin;renardin;SENKIRKIN;nsc-89945;RENARIDINE;Senkarkane;senkirkine;renardine[neutral];Renardine (neutral)
CBNumber: CB9427741
Molecular Formula: C19H27NO6
Formula Weight: 365.42
MOL File: 2318-18-5.mol

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SENKIRKIN Property

Melting point:: 197°C
Boiling point:: 497.19°C (rough estimate)
Density: 1.2439 (rough estimate)
refractive index: 1.5180 (estimate)
storage temp.: -20°C
pka: 12.67±0.40(Predicted)
LogP: 0.690 (est)
IARC: 3 (Vol. 31, Sup 7) 1987

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: 1544
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 2318-18-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89274
Product name: Senkirkine
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $802
Updated: 2024/03/01

AK Scientific

Product number: 2595BB
Product name: Senkirkine
Packaging: 10mg
Price: $860
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS161626
Product name: Senkirkine
Packaging: 25mg
Price: $1300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS161626
Product name: Senkirkine
Packaging: 50mg
Price: $2060
Updated: 2021/12/16

AK Scientific

Product number: 2595BB
Product name: Senkirkine
Packaging: 50mg
Price: $2831
Updated: 2021/12/16

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SENKIRKIN Chemical Properties,Usage,Production

Description

A further hepatotoxiC alkaloid present in Senecio kirkii Hook, S. renardi and Nardosrnia laevigata. The base has [α]²⁵_D - 16° (c 1.89, MeOH) or[α]¹⁵_D - 6.2° (c 1.91, CHCI₃). It forms colourless plates when crystallized from either Me₂CO or AcOEt and yields a picrate, m.p. 225.5-226°C and a picrolonate, m.p. 109- 110°C. The ultraviolet spectrum shows a single absorption maximum at 219 mp.. Several crystalline salts and derivatives are known, e.g. the aurichloride, m.p. 182.5-183.5°C; platinichloride, m.p. 196-7°C (dec.); bitartrate, m.p. 201°C; reineckate, m.p. 169-171°C; picrate, m.p. 225- 225.5°C; picrolonate, m.p. 138°C and the methiodide, m.p. 194-6°C (dec.). The O-acetate occurs naturally (q.v.) in Senecio kirkii.

Definition

ChEBI: Senkirkine is a macrolide.

Safety Profile

Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox

References

Briggs, Mangan, Russell., J. Chern. Soc., 1891 (1948)
Massagetov, Kuzovkov.,J. Gen. Chern., USSR, 23, 158 (1953)
Danilova, Konovalova., ibid, 30, 1921 (1961)
Danilova, Koretskaya, Utkin., ibid, 31, 3815 (1961)
Wunderlich., Chern. Ind., 2089 (1962)
Briggs et al., J. Chern. Soc., 2492 (1965)

SENKIRKIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SENKIRKIN Suppliers

Canada 1 China 43 France 1 Germany 1 India 2 United Kingdom 2 United States 8 Global 58

J & K SCIENTIFIC LTD.

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Sigma-Aldrich

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2318-18-5, SENKIRKINRelated Search:

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RENARIDINE

SENKIKIN

SENKIRKIN

(4Z)-4-Ethylidene-7-hydroxy-6,7,14-trimethyl-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione

11,16-trione,12-hydroxy-4-methyl-8-secosenecionan-8

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8,12-dihydroxy-4-methyl-11,16-dioxo-senecionaniu

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12-Hydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione

SENKIRKIN(RENARDINE)(SH)

Kushenin

nsc-89945

renardin

Renardine (neutral)

renardine[neutral]

Senecionanium, 8,12-dihydroxy-4-methyl-11,16-dioxo-

Senkarkane

senkirkine

Senkirkine (neutral)

senkirkine(neutral)

senkirkine[neutral]

trans-15-Ethylidene-12-beta-hydroxy-4,12-alpha,13-beta-trimethyl 8-oxo-4,8 secosenec-1-enine

2,9-Dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione, 4-ethylidene-7-hydroxy-6,7,14-trimethyl-, (1R,4Z,6R,7R)-

SENKIRKIN(RENARDINE)

2318-18-5

C19H28NO6

Heterocycles

Mutagenesis Research Chemicals