SENKIRKIN Property

Melting point:

197°C

Boiling point:

497.19°C (rough estimate)

Density 

1.2439 (rough estimate)

refractive index 

1.5180 (estimate)

storage temp. 

-20°C

pka

12.67±0.40(Predicted)

LogP

0.690 (est)

IARC

3 (Vol. 31, Sup 7) 1987

Safety

Hazard Codes 

Xn

Risk Statements 

22

RIDADR 

1544

WGK Germany 

3

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

2318-18-5(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

SENKIRKIN Chemical Properties,Usage,Production

Description

A further hepatotoxiC alkaloid present in Senecio kirkii Hook, S. renardi and Nardosrnia laevigata. The base has [α]²⁵_D - 16° (c 1.89, MeOH) or[α]¹⁵_D - 6.2° (c 1.91, CHCI₃). It forms colourless plates when crystallized from either Me₂CO or AcOEt and yields a picrate, m.p. 225.5-226°C and a picrolonate, m.p. 109- 110°C. The ultraviolet spectrum shows a single absorption maximum at 219 mp.. Several crystalline salts and derivatives are known, e.g. the aurichloride, m.p. 182.5-183.5°C; platinichloride, m.p. 196-7°C (dec.); bitartrate, m.p. 201°C; reineckate, m.p. 169-171°C; picrate, m.p. 225- 225.5°C; picrolonate, m.p. 138°C and the methiodide, m.p. 194-6°C (dec.). The O-acetate occurs naturally (q.v.) in Senecio kirkii.

Definition

ChEBI: Senkirkine is a macrolide.

Safety Profile

Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox

References

Briggs, Mangan, Russell., J. Chern. Soc., 1891 (1948)
Massagetov, Kuzovkov.,J. Gen. Chern., USSR, 23, 158 (1953)
Danilova, Konovalova., ibid, 30, 1921 (1961)
Danilova, Koretskaya, Utkin., ibid, 31, 3815 (1961)
Wunderlich., Chern. Ind., 2089 (1962)
Briggs et al., J. Chern. Soc., 2492 (1965)