ChemicalBook > CAS DataBase List > SENKIRKIN

SENKIRKIN

Product Name: SENKIRKIN
CAS No.: 2318-18-5
Chemical Name: SENKIRKIN
Synonyms: SENKIKIN;Kushenin;renardin;SENKIRKIN;nsc-89945;RENARIDINE;Senkarkane;senkirkine;renardine[neutral];Renardine (neutral)
CBNumber: CB9427741
Molecular Formula: C19H27NO6
Formula Weight: 365.42
MOL File: 2318-18-5.mol

Less

SENKIRKIN Property

Melting point:: 197°C
Boiling point:: 497.19°C (rough estimate)
Density: 1.2439 (rough estimate)
refractive index: 1.5180 (estimate)
storage temp.: -20°C
form: Solid
pka: 12.67±0.40(Predicted)
color: White to off-white
LogP: 0.690 (est)
IARC: 3 (Vol. 31, Sup 7) 1987

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: 1544
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 2318-18-5(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89274
Product name: Senkirkine
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $708
Updated: 2025/07/31

AK Scientific

Product number: 2595BB
Product name: Senkirkine
Packaging: 10mg
Price: $860
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS161626
Product name: Senkirkine
Packaging: 25mg
Price: $1300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS161626
Product name: Senkirkine
Packaging: 50mg
Price: $2060
Updated: 2021/12/16

AK Scientific

Product number: 2595BB
Product name: Senkirkine
Packaging: 50mg
Price: $2831
Updated: 2021/12/16

Less

SENKIRKIN Chemical Properties,Usage,Production

Description

A further hepatotoxiC alkaloid present in Senecio kirkii Hook, S. renardi and Nardosrnia laevigata. The base has [α]²⁵_D - 16° (c 1.89, MeOH) or[α]¹⁵_D - 6.2° (c 1.91, CHCI₃). It forms colourless plates when crystallized from either Me₂CO or AcOEt and yields a picrate, m.p. 225.5-226°C and a picrolonate, m.p. 109- 110°C. The ultraviolet spectrum shows a single absorption maximum at 219 mp.. Several crystalline salts and derivatives are known, e.g. the aurichloride, m.p. 182.5-183.5°C; platinichloride, m.p. 196-7°C (dec.); bitartrate, m.p. 201°C; reineckate, m.p. 169-171°C; picrate, m.p. 225- 225.5°C; picrolonate, m.p. 138°C and the methiodide, m.p. 194-6°C (dec.). The O-acetate occurs naturally (q.v.) in Senecio kirkii.

Uses

Senkirkin, a pyrrolizidine alkaloid, occured in the aerial parts of the medicinal plant Tussilago farfara, could induce chromosome damage in human lymphocytes. Senkirkin can be metabolized by CYP3A4[1].

Definition

ChEBI: Senkirkine is a macrolide.

Safety Profile

Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox

References

Briggs, Mangan, Russell., J. Chern. Soc., 1891 (1948)
Massagetov, Kuzovkov.,J. Gen. Chern., USSR, 23, 158 (1953)
Danilova, Konovalova., ibid, 30, 1921 (1961)
Danilova, Koretskaya, Utkin., ibid, 31, 3815 (1961)
Wunderlich., Chern. Ind., 2089 (1962)
Briggs et al., J. Chern. Soc., 2492 (1965)

SENKIRKIN Preparation Products And Raw materials

Raw materials

Preparation Products

Less

SENKIRKIN Suppliers

Canada 1 China 57 France 1 Germany 1 India 2 United Kingdom 2 United States 7 Global 71

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD.

Tel: 86-029-85456576
Fax: 86-029-85456576-808
Email: daisy_wang@vip.163.com
Country: China
ProdList: 292
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

Biyu Biotechnology (Shanghai) Co., ltd

Tel: 021-26018599
Country: China
ProdList: 270
Advantage: 56

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9751
Advantage: 58

Chengdu Greenpure Biopharma CO.,Ltd

Tel: 028-88203606; 18283602253
Email: jancyzheng@gcgreenpure.com
Country: China
ProdList: 1594
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Finetech Industry Limited

Tel: +86-27-8746-5837 +8619945049750
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9629
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5167
Advantage: 58

ShangHai Anpel Co, Ltd.

Tel: 18501792038 18502138905
Email: shanpel@anpel.com.cn
Country: China
ProdList: 9611
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Aleshan (Guangzhou) Biotechnology Co., Ltd

Tel: 18636736628
Email: Araratbio@163.com
Country: China
ProdList: 3342
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Guangzhou Yunmen Biotechnology Co., Ltd

Tel: 0751-18902340975/189023400307 18902340307
Fax: 0751-2819901
Email: 3356812514@qq.com
Country: China
ProdList: 9249
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 9968
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815987 13927875076
Fax: 0751-2828607
Email: 3007432263@qq.com
Country: China
ProdList: 9963
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13681877033
Email: 2702713455@qq.com
Country: China
ProdList: 9997
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Naturewill Biotechnology Co., Ltd.

Tel: 028-82632533 18113192475
Email: 3157321941@qq.com
Country: China
ProdList: 4993
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9651
Advantage: 58

Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 9119
Advantage: 58

Shanghai Yanchun Biopharmaceutical Technology Co., Ltd

Tel: 4001-009266 17349750668
Email: product@sci-e.com
Country: China
ProdList: 2808
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: rose.shi@synzest.com
Country: China
ProdList: 6210
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

Hubei CuiRan Biotechnology Co., Ltd.

Tel: 00-1816279-5156 18162795156
Email: 3391961471@qq.com
Country: China
ProdList: 4332
Advantage: 58

SHANGHAI ZZBIO CO., LTD.

Tel: 15102117276 19921389125
Email: tech@zzbioco.com
Country: China
ProdList: 12064
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

BePure (Beijing) Biotechnology Co.

Tel: 58896805
Email: 7993601name@qq.com
Country: CHINA
ProdList: 6620
Advantage: 58

Chengdu DeSiTe Biological Technology Co., Ltd

Tel: 17308096051
Email: 3001048290@qq.com
Country: China
ProdList: 6219
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18651614124
Email: 2881516338@qq.com
Country: China
ProdList: 10000
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

ShangHai ZskBio CO., LTD

Tel: 021-58056897 15399714481
Email: info@zsklab.com
Country: China
ProdList: 7190
Advantage: 58

Shanghai Zheyan Biotech Co., Ltd.

Tel: 18017610038
Email: zheyansh@163.com
Country: CHINA
ProdList: 3619
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +86-18621343501; +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33338
Advantage: 58

Shaanxi Didu New Materials Co. Ltd

Tel: +86-89586680 +86-13289823923
Email: 1026@dideu.com
Country: China
ProdList: 9080
Advantage: 58

Chengdu Youngshe Chemical Co., Ltd.

Tel: +8618108235634
Email: Cecilia@youngshechem.com
Country: China
ProdList: 2345
Advantage: 58

Guangzhou Dedou Life Science Co., Ltd

Tel
Country: CHINA
ProdList: 0
Advantage: 58

2318-18-5, SENKIRKINRelated Search:

alpha-Terpineol alpha-Cyperone beta-Sitosterol Hydroxyecdysone hydroxygenkwanin 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Artemether MOSLOFLAVONE beta-Eudesmol (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one SENKIRKIN (S)-ALLYL LACTATE 1,4-DIACETOXY-2-OXOBUTANE

RENARIDINE

SENKIKIN

SENKIRKIN

(4Z)-4-Ethylidene-7-hydroxy-6,7,14-trimethyl-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione

11,16-trione,12-hydroxy-4-methyl-8-secosenecionan-8

2,12-Dihydroxy-4-methyl-11,16-dioxosenecionanium

4,8-Secosenecionan-8,11,16-trione, 12-hydroxy-4-methyl-

8,12-dihydroxy-4-methyl-11,16-dioxo-senecionaniu

trans-15-ethylidene-12-beta-hydroxy-4,12-alpha,13-beta-trimethyl8-oxo-4,8se

12-Hydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione

SENKIRKIN(RENARDINE)(SH)

Kushenin

nsc-89945

renardin

Renardine (neutral)

renardine[neutral]

Senecionanium, 8,12-dihydroxy-4-methyl-11,16-dioxo-

Senkarkane

senkirkine

Senkirkine (neutral)

senkirkine(neutral)

senkirkine[neutral]

trans-15-Ethylidene-12-beta-hydroxy-4,12-alpha,13-beta-trimethyl 8-oxo-4,8 secosenec-1-enine

2,9-Dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione, 4-ethylidene-7-hydroxy-6,7,14-trimethyl-, (1R,4Z,6R,7R)-

SENKIRKIN(RENARDINE)

Senkirkine 100 μg/mL in Water

Pyrrolizidine alkaloids Mixture 661 100 μg/mL in Methanol

2318-18-5

C19H28NO6

Heterocycles

Mutagenesis Research Chemicals