ChemicalBook > CAS DataBase List > 5-METHOXYBENZIMIDAZOLE

5-METHOXYBENZIMIDAZOLE

Product Name
5-METHOXYBENZIMIDAZOLE
CAS No.
4887-80-3
Chemical Name
5-METHOXYBENZIMIDAZOLE
Synonyms
BUTTPARK 146\15-76;5-METHOXYBENZIMIDAZOLE;1H-Benzimidazole,5-meth;Esomeprazole Impurity 106;5-METHOXY-1H-BENZIMIDAZOLE;5-Methoxybenzimidazole 97%;6-methoxy-1H-benzimidazole;5-Methoxybenzimidazole,97%;5-Methoxybenzimidazole,99%;5-Methoxy-1H-benzoiMidazole
CBNumber
CB9457735
Molecular Formula
C8H8N2O
Formula Weight
148.16
MOL File
4887-80-3.mol
More
Less

5-METHOXYBENZIMIDAZOLE Property

Melting point:
121-126 °C (lit.)
Boiling point:
190-195 °C(Press: 0.03 Torr)
Density 
1.244±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
solid
pka
13.12±0.10(Predicted)
color 
Light brown to brown
InChI
InChI=1S/C8H8N2O/c1-11-6-2-3-7-8(4-6)10-5-9-7/h2-5H,1H3,(H,9,10)
InChIKey
ILMHAGCURJPNRZ-UHFFFAOYSA-N
SMILES
C1NC2=CC(OC)=CC=C2N=1
CAS DataBase Reference
4887-80-3(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-24/25
WGK Germany 
3
HS Code 
29332990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
515108
Product name
5-Methoxybenzimidazole
Purity
97%
Packaging
5g
Price
$186
Updated
2022/05/15
TRC
Product number
M916000
Product name
6-Methoxy-1H-benzimidazole
Packaging
5g
Price
$200
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-1-1V
Product name
5-Methoxy-1H-benzimidazole
Packaging
5G
Price
$120
Updated
2021/12/16
AK Scientific
Product number
X6271
Product name
5-Methoxybenzimazole
Packaging
10g
Price
$134
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-1-1V
Product name
5-Methoxy-1H-benzimidazole
Packaging
10g
Price
$176
Updated
2021/12/16
More
Less

5-METHOXYBENZIMIDAZOLE Chemical Properties,Usage,Production

Chemical Properties

White to brown powder

Uses

6-Methoxy-1H-benzimidazole has been studied for its anti-proliferative activity, and a preliminary in vivo toxicity study against a panel of non-small cell lung cancer cell lines.

Synthesis

22019-71-2

4887-80-3

To a 16 mL reaction flask equipped with a PTFE/silicone septum and a nitrogen bubbler was added N-benzylbenzimidazole (208.1 mg, 1.0 mmol), dried Pd/C catalyst (10 wt%, 20 mg) and THF (5 mL). Triethylsilane (320 μL, 2.0 mmol) was added dropwise to the mixture under nitrogen protection, followed by continuous stirring at room temperature for 14 hours. After completion of the reaction, the reaction mixture was filtered through a 0.45 μm PTFE syringe filter and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (eluent: 0 to 10% methanol/dichloromethane gradient) to afford 5-methoxybenzimidazole as a colorless solid (117.6 mg, 0.996 mmol, 99% yield). It is worth noting that the reaction typically suffers from an induction period of 5 to 30 min, which can be observed by the release of gas from the reaction mixture (i.e., the bubbling phenomenon). The use of a dry Pd/C catalyst is critical to the success of the reaction, and wet Pd/C may result in a significant decrease in yield or inability of the reaction to proceed.

References

[1] Tetrahedron Letters, 2015, vol. 56, # 21, p. 2688 - 2690

5-METHOXYBENZIMIDAZOLE Preparation Products And Raw materials

Raw materials

Ethanol Acetic anhydride Potassium hydroxide Formic acid Palladium p-Anisidine Ethyl acetate Hydrochloric acid Nitric acid Acetic acid

Preparation Products

More
Less

5-METHOXYBENZIMIDAZOLE Suppliers

China 101 Czech Republic 1 Europe 1 France 1 Germany 5 India 8 Japan 1 Switzerland 1 United Kingdom 10 United States 23 Global 152
CHANGZHOU MALONG CHEMICALS CO., LTD.
Tel
18651958646
Email
info@malongchem.com
Country
China
ProdList
180
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Tel
0512-68780025 18962125825
Email
sales@ryanchem.com
Country
China
ProdList
167
Advantage
62
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Acorn PharmaTech Co., Ltd.
Tel
025-58395930
Fax
025-5861-9182
Email
sales@acornpharma.com
Country
China
ProdList
982
Advantage
60
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd.
Tel
02161555100
Fax
-
Country
China
ProdList
820
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Chengdu DingDang Pharmaceutical Co., Ltd.
Tel
028-86040038 13980902949;
Fax
028-85149890
Email
market@dingdangchem.com
Country
China
ProdList
1853
Advantage
55
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9279
Advantage
55
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
6059
Advantage
65
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20794
Advantage
60
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Zhengzhou Huiju Chemical Co., Ltd.
Tel
0371-55900031 18137872243
Fax
QQ：2853979815
Email
2853979815@qq.com
Country
China
ProdList
9996
Advantage
55
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai Puhao Chemical Technology Co. Ltd.
Tel
13761817188
Email
774028079@qq.com
Country
China
ProdList
291
Advantage
58
Suzhou Rovathin Foreign Trade Co.,Ltd
Tel
0512-65816829 18662214788
Fax
0512-65816829
Email
info@rovathin.com.cn
Country
China
ProdList
9987
Advantage
58
Henan Alfa Chemical Co., Ltd
Tel
+8615838112936
Email
alfa10@alfachem.cn
Country
China
ProdList
12921
Advantage
58
Changzhou Fullone Chemical Co., Ltd.
Tel
+86-13328197671 +86-13861172460
Email
sales@borenchem.cn
Country
China
ProdList
1055
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Baoji Guokang Healthchem Co., Ltd.
Tel
+86-0917-3909592 +86-13892490616
Fax
09173909592
Email
gksales1@gk-bio.com
Country
China
ProdList
9209
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 19925672674
Fax
QQ 3008233717
Email
3008233746@qq.com
Country
China
ProdList
9883
Advantage
12
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23912
Advantage
58
Shanghai Lanle Bird Industrial Co., Ltd.
Tel
15021845385
Email
765325601@qq.com
Country
China
ProdList
3609
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Zhengzhou anmousse chemical products co. LTD
Tel
0371-55289822 18737195735
Fax
QQ:483339295
Email
483339295@qq.com
Country
China
ProdList
7587
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
More
Less

View Lastest Price from 5-METHOXYBENZIMIDAZOLE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-METHOXYBENZIMIDAZOLE 4887-80-3
Price
US $1.00-2.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2024-08-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-METHOXYBENZIMIDAZOLE 4887-80-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-METHOXYBENZIMIDAZOLE 4887-80-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

4887-80-3, 5-METHOXYBENZIMIDAZOLERelated Search:

5-METHOXYBENZIMIDAZOLE 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Esomeprazole 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE 5-HYDROXY OMEPRAZOLE 5,6-Dimethoxybenzimidazole Oxibendazole 1,3-Dihydro-5-methoxy-2H-benzimidazole-2-one~2-Hydroxy-5-methoxybenzimidazole,2-HYDROXY-5-METHOXYBENZIMIDAZOLE 2-[(4-METHOXYETHOXY-3,5-DIMETHYL-2-PYRIDINYL)-METHYLTHIO]-5-METHOXYBENZIMIDAZOLE Triclabendazole 2-[(4-METHOXY-3,5-DIMETHYLPYRID-2-YL)-METHYLSULFO]-5-METHOXYBENZIMIDAZOLE 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE-4,6,7-D3 5-Methoxybenzimidazole-2-carboxylic acid monohydrate 2-CHLORO-5-METHOXYBENZIMIDAZOLE 2-[(4-METHOXY-3,5-DIMETHYLPYRID-2-YL)-METHYLSULFO]-5-METHOXYBENZIMIDAZOLE 5-Methoxybenzimidazole-2-methanol 2-METHYL-5,6-DIMETHOXYBENZIMIDAZOLE 6,7-DIHYDRO-1H-[1,4]DIOXINO[2',3':4,5]BENZO[D]IMIDAZOLE-2-THIOL

  • 5-Methoxy-1H-benzoiMidazole
  • 5-Methoxy-1H-benzo[d]iMidazole
  • 5-Methoxybenzimidazole 97%
  • 5-METHOXYBENZIMIDAZOLE
  • 5-METHOXY-1H-BENZIMIDAZOLE
  • BUTTPARK 146\15-76
  • 5-Methoxybenzimidazole,99%
  • 1H-Benzimidazole,5-methoxy-(9CI)
  • 5-Methoxybenzimidazole,97%
  • 6-methoxy-1H-benzimidazole
  • 6-Methoxy-1H-benzo[d]iMidazole
  • 1H-Benzimidazole,5-meth
  • Esomeprazole Impurity 106
  • 1H-Benzimidazole, 6-methoxy-
  • 4887-80-3
  • Heterocyclic Building Blocks
  • Building Blocks
  • Benzimidazoles
  • BENZIMIDAZOLE
  • pharmacetical
  • Imidazol&Benzimidazole
  • Benzimidazoles
  • Building Blocks
  • Heterocyclic Building Blocks