5-METHOXYBENZIMIDAZOLE
- Product Name
- 5-METHOXYBENZIMIDAZOLE
- CAS No.
- 4887-80-3
- Chemical Name
- 5-METHOXYBENZIMIDAZOLE
- Synonyms
- BUTTPARK 146\15-76;5-METHOXYBENZIMIDAZOLE;1H-Benzimidazole,5-meth;Esomeprazole Impurity 106;5-METHOXY-1H-BENZIMIDAZOLE;5-Methoxybenzimidazole 97%;6-methoxy-1H-benzimidazole;5-Methoxybenzimidazole,97%;5-Methoxybenzimidazole,99%;5-Methoxy-1H-benzoiMidazole
- CBNumber
- CB9457735
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 4887-80-3.mol
5-METHOXYBENZIMIDAZOLE Property
- Melting point:
- 121-126 °C (lit.)
- Boiling point:
- 190-195 °C(Press: 0.03 Torr)
- Density
- 1.244±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- 13.12±0.10(Predicted)
- color
- Light brown to brown
- InChI
- InChI=1S/C8H8N2O/c1-11-6-2-3-7-8(4-6)10-5-9-7/h2-5H,1H3,(H,9,10)
- InChIKey
- ILMHAGCURJPNRZ-UHFFFAOYSA-N
- SMILES
- C1NC2=CC(OC)=CC=C2N=1
- CAS DataBase Reference
- 4887-80-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- HS Code
- 29332990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 515108
- Product name
- 5-Methoxybenzimidazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $186
- Updated
- 2022/05/15
- Product number
- M916000
- Product name
- 6-Methoxy-1H-benzimidazole
- Packaging
- 5g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- OR11201
- Product name
- 5-Methoxy-1H-benzimidazole
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- X6271
- Product name
- 5-Methoxybenzimazole
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- OR11201
- Product name
- 5-Methoxy-1H-benzimidazole
- Packaging
- 5g
- Price
- $53
- Updated
- 2021/12/16
5-METHOXYBENZIMIDAZOLE Chemical Properties,Usage,Production
Chemical Properties
White to brown powder
Uses
6-Methoxy-1H-benzimidazole has been studied for its anti-proliferative activity, and a preliminary in vivo toxicity study against a panel of non-small cell lung cancer cell lines.
Synthesis
22019-71-2
4887-80-3
To a 16 mL reaction flask equipped with a PTFE/silicone septum and a nitrogen bubbler was added N-benzylbenzimidazole (208.1 mg, 1.0 mmol), dried Pd/C catalyst (10 wt%, 20 mg) and THF (5 mL). Triethylsilane (320 μL, 2.0 mmol) was added dropwise to the mixture under nitrogen protection, followed by continuous stirring at room temperature for 14 hours. After completion of the reaction, the reaction mixture was filtered through a 0.45 μm PTFE syringe filter and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (eluent: 0 to 10% methanol/dichloromethane gradient) to afford 5-methoxybenzimidazole as a colorless solid (117.6 mg, 0.996 mmol, 99% yield). It is worth noting that the reaction typically suffers from an induction period of 5 to 30 min, which can be observed by the release of gas from the reaction mixture (i.e., the bubbling phenomenon). The use of a dry Pd/C catalyst is critical to the success of the reaction, and wet Pd/C may result in a significant decrease in yield or inability of the reaction to proceed.
References
[1] Tetrahedron Letters, 2015, vol. 56, # 21, p. 2688 - 2690
5-METHOXYBENZIMIDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
5-METHOXYBENZIMIDAZOLE Suppliers
- Tel
- --
- Fax
- --
- fr.fisher@thermofisher.com
- Country
- France
- ProdList
- 614
- Advantage
- 58
View Lastest Price from 5-METHOXYBENZIMIDAZOLE manufacturers
- Product
- 5-METHOXYBENZIMIDAZOLE 4887-80-3
- Price
- US $1.00-2.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-08-08
- Product
- 5-METHOXYBENZIMIDAZOLE 4887-80-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-METHOXYBENZIMIDAZOLE 4887-80-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09