Ethyl 5-methylisoxazole-4-carboxylate
- Product Name
- Ethyl 5-methylisoxazole-4-carboxylate
- CAS No.
- 51135-73-0
- Chemical Name
- Ethyl 5-methylisoxazole-4-carboxylate
- Synonyms
- 5-METHYL-4-ISOXAZOLECARBOXYLATE;ETHYL 3-METHYLPYRAZOLE-4-CARBOXYLATE;ethyl 5-methyl-4-isoxazolecarboxylate;ETHYL 5-METHYLISOXAZOLE-4-CARBOXYLATE;Ethyl-5-methylisoxzaole-4 carboxylate;ethyl 5-methylisoxazol-4-yl-carboxylate;ethyl 5-methyl-1,2-oxazole-4-carboxylate;3-ethyl-5-methyl-1H-pyrazole-4-carboxylate;5-Methylisoxazole-4-carboxylic acid ethyl ester;5-methyl-4-isoxazolecarboxylic acid ethyl ester
- CBNumber
- CB9459209
- Molecular Formula
- C7H9NO3
- Formula Weight
- 155.15
- MOL File
- 51135-73-0.mol
Ethyl 5-methylisoxazole-4-carboxylate Property
- Melting point:
- 49-52°C
- Boiling point:
- 95-97°C 15mm
- Density
- 1.118 g/mL at 25 °C
- refractive index
- 1.4597
- Flash point:
- 95-97°C/15mm
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol
- form
- Solid
- pka
- -3.53±0.50(Predicted)
- color
- Yellow
- BRN
- 122097
- CAS DataBase Reference
- 51135-73-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 681016
- Product name
- Ethyl 5-methylisoxazole-4-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $55.5
- Updated
- 2023/06/20
- Product number
- 681016
- Product name
- Ethyl 5-methylisoxazole-4-carboxylate
- Purity
- 97%
- Packaging
- 25g
- Price
- $230
- Updated
- 2022/05/15
- Product number
- E926843
- Product name
- Ethyl 5-methylisoxazole-4-carboxylate
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- E8609-30
- Product name
- Ethyl 3-Methylpyrazole-4-carboxylate
- Packaging
- 1g
- Price
- $403
- Updated
- 2021/12/16
- Product number
- Q091
- Product name
- Ethyl5-methyl-4-isoxazolecarboxylate
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
Ethyl 5-methylisoxazole-4-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
Shows systemic antifungal activity accompanied by high levels of phytotoxicity.
Synthesis
3788-94-1
51135-73-0
General procedure for the synthesis of ethyl 5-methyl-4-isoxazolecarboxylate from ethyl 2-ethoxymethyleneacetoacetate: ethyl 2-ethoxymethyleneacetoacetate (110.00 g, 0.59 mol) was dissolved in methanol (330 ml) and cooled down to -0 °C. At -5 to 0°C, 50.0% aqueous hydroxylamine (39.03 g, 0.59 mol anhydrous) was slowly added, and the addition time was controlled within 1 hour. After addition, stirring was continued at -0 °C for 30 min. Subsequently, the reaction mixture was warmed up to 20-30 °C and refluxed for 1 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was cooled to room temperature. Hexane (500 ml) was added to the residue and stirred for 30 minutes. Then, saturated sodium bicarbonate solution (100 ml) and water (400 ml) were added sequentially, stirred thoroughly and left to stratify. The organic layer was separated and the aqueous layer was re-extracted with hexane (2 x 200 ml). All organic layers were combined and washed with water (2 x 250 ml). Finally, the solvent was removed under reduced pressure to give a yellow thick oil-like product of ethyl 5-methyl-4-isoxazolecarboxylate 72.5 g in 79% yield, with HPLC purity of 98.7% and isomer impurity content below 0.5%.
References
[1] Patent: WO2007/86076, 2007, A2. Location in patent: Page/Page column 5-7
[2] Letters in Drug Design and Discovery, 2016, vol. 13, # 9, p. 912 - 920
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 1875 - 1880
[4] Asian Journal of Chemistry, 2010, vol. 22, # 2, p. 1503 - 1506
Ethyl 5-methylisoxazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 5-methylisoxazole-4-carboxylate manufacturers
- Product
- Ethyl 5-methylisoxazole-4-carboxylate 51135-73-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31