MICROCYSTIN-LR

ChemicalBook > CAS DataBase List > MICROCYSTIN-LR

Product Name: MICROCYSTIN-LR
CAS No.: 101043-37-2
Chemical Name: MICROCYSTIN-LR
Synonyms: MC-LR;Microcystin-LR solution,Cyanoginosin, Fast-death factor;C05371;MCYST-LR;akerstox;toxin-lr;microcystin-a;MICROCYSTIN-LR;CYANOGINOSIN-LR;Microcystin LR 95%
CBNumber: CB9463679
Molecular Formula: C49H74N10O12
Formula Weight: 995.17
MOL File: 101043-37-2.mol

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MICROCYSTIN-LR Property

Density: 1.29±0.1 g/cm3(Predicted)
Flash point:: 11 °C
storage temp.: −20°C
solubility: ethanol: 1 mg/mL
form: solid film
pka: 3.03±0.70(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.
IARC: 2B (Vol. 94) 2010
EPA Substance Registry System: Microcystin LR (101043-37-2)

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Safety

Hazard Codes: T+,T,F
Risk Statements: 26/27/28-36/37/38-43-39/23/24/25-23/24/25-11
Safety Statements: 26-36/37/39-45-36/37-16-7
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: GT2810000
HS Code: 30029090
Hazardous Substances Data: 101043-37-2(Hazardous Substances Data)
Toxicity: LD50 orl-rat: >5 mg/kg HETOEA 18,162,1999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 33893
Product name: Microcystin-LR solution
Purity: 10?μg/mL in methanol, analytical standard
Packaging: 1mL
Price: $464
Updated: 2024/03/01

Cayman Chemical

Product number: 10007188
Product name: Microcystin-LR
Purity: ≥95%
Packaging: 100μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 10007188
Product name: Microcystin-LR
Purity: ≥95%
Packaging: 50μg
Price: $29
Updated: 2021/12/16

Cayman Chemical

Product number: 10007188
Product name: Microcystin-LR
Purity: ≥95%
Packaging: 500μg
Price: $286
Updated: 2024/03/01

Cayman Chemical

Product number: 10007188
Product name: Microcystin-LR
Purity: ≥95%
Packaging: 1mg
Price: $502
Updated: 2024/03/01

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MICROCYSTIN-LR Chemical Properties,Usage,Production

Description

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC₅₀= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM. The PP1 IC₅₀ is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.

Definition

ChEBI: Microcystin-LR is a microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins. It has a role as a bacterial metabolite, an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor, a xenobiotic and an environmental contaminant.

Hazard

A poison by ingestion and inhalation.

Safety Profile

A poison by ingestion, inhalation,intraperitoneal, and intravenous route. Experimentalreproductive effects. When heated to decomposition itemits toxic vapors of NOx.

References

1) Rinehart?et al.?(1988),?Nodularin, microcystin, and the configuration of Adda; J. Am. Chem. Soc.,?110?8557 2) Honkanen?et al. (1990),?Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases;?J. Biol. Chem,?265?19401 3) Runnegar?et al.?(1995),?Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters; Toxicol. Appl. Pharmacol.,?134?264

MICROCYSTIN-LR Preparation Products And Raw materials

Raw materials

Preparation Products

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MICROCYSTIN-LR Suppliers

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101043-37-2, MICROCYSTIN-LRRelated Search:

Tris(2,4-pentanedionato)chroMiuM(III) TERT-BUTYL ISOCYANIDE METHYL ISOCYANOACETATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE N-BUTYLISOCYANIDE Aluminum acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) COBALT(II) ACETYLACETONATE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Ferric acetylacetonate PHENYLSELENOL SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ethyl isocyanoacetate Cupric acetylacetonate Benzyl isocyanide

5-l-arginine-cyanoginosinl

5-l-argininecyanoginosinla

MCYST-LR

5-L-ARGININE-MICROCYSTIN LA

CYANOGINOSIN-LR

Cyanoginosin, Fast-death factor

Cyclo[D-Ala-L-Leu-[(3S)-3-methyl-D-βAsp-]-L-Arg-[(2S,3S)-2-methyl-3-[(1E,3E,5S,6S)-3,5-dimethyl-6-methoxy-7-phenyl-1,3-heptadiene-1-yl]-βAla-]-D-γGlu-N-methyl-Dha-]

5-L-Arginine-cyanoginosin

C05371

Microcystin-LR solution,Cyanoginosin, Fast-death factor

MICROCYSTIN-LR

MICROCYSTIN-LR, MICROCYSTIS AERUGINOSA

Microcystin-LR solution 10 UG/ML IN METHANOL

microcystin lr from microcystis aeruginosa

microcystin-lr solution

TOXIN,BLUE-GREENALGA

Microcystin LR 95%

cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]

CYANOGINOSIN-LR;MC-LR

MC-LR

akerstox

microcystin-a

microcystisaeruginosatoxin

toxin,bluegreenalga,microcystisaeruginosa

toxini(microcystisaeruginosa)

toxin-lr

toxint17(microcystisaeruginosa)

Microcystin LR Solution in Methanol,10μg/mL

cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl

(5R,8S,11R,12S,15S,18S,19S,22R)-15-(3-guanidinopropyl)-8-isobutyl-18-((1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl)-1,5,12,19-tetramethyl-2-methylene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid

Microcystin-LR Standard Solution

Microcystine LR in Methanol

101043-37-2

C49H74N10O12

Kinase/Phosphatase Biology

Protein Phosphatase 1 (PP1)

Serine/Threonine Phosphatase Inhibitors

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Natural Products